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Vitamin D deficiency, coronary artery disease, and endothelial dysfunction: observations from a coronary angiographic study in Indian patients.
J Invasive Cardiol. 2012 Aug; 24(8):385-9.JI

Abstract

BACKGROUND AND METHODS

Vitamin D deficiency has been linked to an increased risk of coronary artery disease (CAD) and cardiovascular (CV) death. Endothelial dysfunction plays an important role in pathogenesis of CAD and vitamin D deficiency is postulated to promote endothelial dysfunction. Despite rising trends of CAD in Asians, only limited data are available on the relationship between vitamin D, CAD, and endothelial dysfunction.

RESULTS

In a study of 100 patients undergoing coronary angiography, mean 25(OH)D level was 14.8 ± 9.1 ng/mL; vitamin D deficiency was present in 80% and only 7% had optimal 25(OH)D levels. Nearly one-third (36%) were severely deficient, with 25(OH)D levels <10 ng/mL. Those with vitamin D deficiency had significantly higher prevalence of double- or triple-vessel CAD (53% vs 38%), diffuse CAD (56% vs 34%), and higher number of coronary vessels involved as compared to those with higher 25(OH)D levels. Those with lower 25(OH)D levels had significantly lower brachial artery flow-mediated dilation (FMD; 4.57% vs 10.68%: P<.001) and significantly higher prevalence of impaired FMD (values <4.5%; 50.6% vs 7%; P<.002). A graded relationship between 25(OH)D levels and FMD was observed; impaired FMD was noted in 62.2%, 38.6%, and 13.3% in those with 25(OH)D levels <10 ng/mL, 10-20 ng/mL, and >20 ng/mL, respectively.

CONCLUSION

Indian patients with angiographically documented CAD frequently have vitamin D deficiency. Patients with lower 25(OH)D levels had higher prevalence of double- or triple-vessel CAD and diffuse CAD. Endothelial dysfunction as assessed by brachial artery FMD was also more frequently observed in those with low 25(OH)D levels.

Authors+Show Affiliations

Department of Cardiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Luck now 226014, India. akapoor65@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22865308

Citation

Syal, Sanjeev Kumar, et al. "Vitamin D Deficiency, Coronary Artery Disease, and Endothelial Dysfunction: Observations From a Coronary Angiographic Study in Indian Patients." The Journal of Invasive Cardiology, vol. 24, no. 8, 2012, pp. 385-9.
Syal SK, Kapoor A, Bhatia E, et al. Vitamin D deficiency, coronary artery disease, and endothelial dysfunction: observations from a coronary angiographic study in Indian patients. J Invasive Cardiol. 2012;24(8):385-9.
Syal, S. K., Kapoor, A., Bhatia, E., Sinha, A., Kumar, S., Tewari, S., Garg, N., & Goel, P. K. (2012). Vitamin D deficiency, coronary artery disease, and endothelial dysfunction: observations from a coronary angiographic study in Indian patients. The Journal of Invasive Cardiology, 24(8), 385-9.
Syal SK, et al. Vitamin D Deficiency, Coronary Artery Disease, and Endothelial Dysfunction: Observations From a Coronary Angiographic Study in Indian Patients. J Invasive Cardiol. 2012;24(8):385-9. PubMed PMID: 22865308.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D deficiency, coronary artery disease, and endothelial dysfunction: observations from a coronary angiographic study in Indian patients. AU - Syal,Sanjeev Kumar, AU - Kapoor,Aditya, AU - Bhatia,Eesh, AU - Sinha,Archana, AU - Kumar,Sudeep, AU - Tewari,Satyendra, AU - Garg,Naveen, AU - Goel,Pravin K, PY - 2012/8/7/entrez PY - 2012/8/7/pubmed PY - 2013/1/16/medline SP - 385 EP - 9 JF - The Journal of invasive cardiology JO - J Invasive Cardiol VL - 24 IS - 8 N2 - BACKGROUND AND METHODS: Vitamin D deficiency has been linked to an increased risk of coronary artery disease (CAD) and cardiovascular (CV) death. Endothelial dysfunction plays an important role in pathogenesis of CAD and vitamin D deficiency is postulated to promote endothelial dysfunction. Despite rising trends of CAD in Asians, only limited data are available on the relationship between vitamin D, CAD, and endothelial dysfunction. RESULTS: In a study of 100 patients undergoing coronary angiography, mean 25(OH)D level was 14.8 ± 9.1 ng/mL; vitamin D deficiency was present in 80% and only 7% had optimal 25(OH)D levels. Nearly one-third (36%) were severely deficient, with 25(OH)D levels <10 ng/mL. Those with vitamin D deficiency had significantly higher prevalence of double- or triple-vessel CAD (53% vs 38%), diffuse CAD (56% vs 34%), and higher number of coronary vessels involved as compared to those with higher 25(OH)D levels. Those with lower 25(OH)D levels had significantly lower brachial artery flow-mediated dilation (FMD; 4.57% vs 10.68%: P<.001) and significantly higher prevalence of impaired FMD (values <4.5%; 50.6% vs 7%; P<.002). A graded relationship between 25(OH)D levels and FMD was observed; impaired FMD was noted in 62.2%, 38.6%, and 13.3% in those with 25(OH)D levels <10 ng/mL, 10-20 ng/mL, and >20 ng/mL, respectively. CONCLUSION: Indian patients with angiographically documented CAD frequently have vitamin D deficiency. Patients with lower 25(OH)D levels had higher prevalence of double- or triple-vessel CAD and diffuse CAD. Endothelial dysfunction as assessed by brachial artery FMD was also more frequently observed in those with low 25(OH)D levels. SN - 1557-2501 UR - https://www.unboundmedicine.com/medline/citation/22865308/Vitamin_D_deficiency_coronary_artery_disease_and_endothelial_dysfunction:_observations_from_a_coronary_angiographic_study_in_Indian_patients_ L2 - http://www.invasivecardiology.com/articles/vitamin-d-deficiency-coronary-artery-disease-and-endothelial-dysfunction-observations-coron DB - PRIME DP - Unbound Medicine ER -