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Antioxidative and hypolipidemic efficacy of alcoholic seed extract of Swietenia macrophylla in streptozotocin diabetic rats.
J Basic Clin Physiol Pharmacol. 2011 Jun 17; 22(1-2):11-21.JB

Abstract

The present study was designed to examine the antioxidative potential and antihyperlipidemic activity of Swietenia macrophylla in streptozotocin diabetic rats. The experimental groups were rendered diabetic by intraperitoneal injection of a single dose of streptozotocin (STZ; 40 mg/kg body weight, BW). Rats with glucose levels >200 mg/dL were considered diabetic and were divided into five groups. Three groups of diabetic animals were orally administered daily with seed extract (SME) at a dosage of 50, 100 and 200 mg/kg BW. One group of STZ rats was treated as diabetic control and another group orally administered 600 μg/kg BW glibenclamide daily. Repeated daily oral administration of S. macrophylla significantly reduced blood glucose levels after 45 days of treatment. The lipid peroxidation products such as thiobarbituric acid reactive substances and lipid hydroperoxides of SME treated rats decreased in the plasma, liver and kidney. Glutathione peroxidase, superoxide dismutase and catalase activity were significantly increased in SME treated rats. Antioxidants such as reduced glutathione level in the plasma, liver and kidney and vitamins C and E levels in the plasma increased in SME treated rats. Total cholesterol, triglycerides, phospholipids and free fatty acids and lipoproteins levels increased. Altered lipid profile of treated rats lead to normality with treatment of S. macrophylla. Thus, our results indicate that the administration of 100 mg/kg BW SME restores near normal blood glucose, redox status and lipid profile in STZ-diabetic rats.

Authors+Show Affiliations

Department of Biochemistry and Biotechnology, Annamalai University, Annamalainagar, Tamil Nadu, India.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22865358

Citation

Kalpana, Kalaivanan, and Kodukkur Viswanathan Pugalendi. "Antioxidative and Hypolipidemic Efficacy of Alcoholic Seed Extract of Swietenia Macrophylla in Streptozotocin Diabetic Rats." Journal of Basic and Clinical Physiology and Pharmacology, vol. 22, no. 1-2, 2011, pp. 11-21.
Kalpana K, Pugalendi KV. Antioxidative and hypolipidemic efficacy of alcoholic seed extract of Swietenia macrophylla in streptozotocin diabetic rats. J Basic Clin Physiol Pharmacol. 2011;22(1-2):11-21.
Kalpana, K., & Pugalendi, K. V. (2011). Antioxidative and hypolipidemic efficacy of alcoholic seed extract of Swietenia macrophylla in streptozotocin diabetic rats. Journal of Basic and Clinical Physiology and Pharmacology, 22(1-2), 11-21. https://doi.org/10.1515/jbcpp.2011.001
Kalpana K, Pugalendi KV. Antioxidative and Hypolipidemic Efficacy of Alcoholic Seed Extract of Swietenia Macrophylla in Streptozotocin Diabetic Rats. J Basic Clin Physiol Pharmacol. 2011 Jun 17;22(1-2):11-21. PubMed PMID: 22865358.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidative and hypolipidemic efficacy of alcoholic seed extract of Swietenia macrophylla in streptozotocin diabetic rats. AU - Kalpana,Kalaivanan, AU - Pugalendi,Kodukkur Viswanathan, Y1 - 2011/06/17/ PY - 2012/8/7/entrez PY - 2011/1/1/pubmed PY - 2012/9/5/medline SP - 11 EP - 21 JF - Journal of basic and clinical physiology and pharmacology JO - J Basic Clin Physiol Pharmacol VL - 22 IS - 1-2 N2 - The present study was designed to examine the antioxidative potential and antihyperlipidemic activity of Swietenia macrophylla in streptozotocin diabetic rats. The experimental groups were rendered diabetic by intraperitoneal injection of a single dose of streptozotocin (STZ; 40 mg/kg body weight, BW). Rats with glucose levels >200 mg/dL were considered diabetic and were divided into five groups. Three groups of diabetic animals were orally administered daily with seed extract (SME) at a dosage of 50, 100 and 200 mg/kg BW. One group of STZ rats was treated as diabetic control and another group orally administered 600 μg/kg BW glibenclamide daily. Repeated daily oral administration of S. macrophylla significantly reduced blood glucose levels after 45 days of treatment. The lipid peroxidation products such as thiobarbituric acid reactive substances and lipid hydroperoxides of SME treated rats decreased in the plasma, liver and kidney. Glutathione peroxidase, superoxide dismutase and catalase activity were significantly increased in SME treated rats. Antioxidants such as reduced glutathione level in the plasma, liver and kidney and vitamins C and E levels in the plasma increased in SME treated rats. Total cholesterol, triglycerides, phospholipids and free fatty acids and lipoproteins levels increased. Altered lipid profile of treated rats lead to normality with treatment of S. macrophylla. Thus, our results indicate that the administration of 100 mg/kg BW SME restores near normal blood glucose, redox status and lipid profile in STZ-diabetic rats. SN - 0792-6855 UR - https://www.unboundmedicine.com/medline/citation/22865358/Antioxidative_and_hypolipidemic_efficacy_of_alcoholic_seed_extract_of_Swietenia_macrophylla_in_streptozotocin_diabetic_rats_ L2 - https://www.degruyter.com/doi/10.1515/jbcpp.2011.001 DB - PRIME DP - Unbound Medicine ER -