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Convenient solid phase extraction of cephalosporins in milk using a molecularly imprinted polymer.
Food Chem. 2012 Nov 15; 135(2):775-9.FC

Abstract

In this paper, a molecularly imprinted polymer (MIP) for cephalosporin molecules (cephalexin (CFL) and cephapirin (CFP)), was prepared by non covalent molecular imprinting approach and applied to solid phase extraction (SPE). For MIP synthesis, a tributylammonium cefadroxil salt (TBA-CFD) was used as template with methacrylic acid and ethylene glycol dimethacrylate as monomer and cross-linker, respectively, in acetone-methanol 92/8 (v/v) mixture. The selectivity of MIP versus non imprinted polymer (NIP) was confirmed for CFL, CFD and CFP in standard solutions as well as in milk samples. The efficiency of the synthesized MIP was evaluated by means of the application of the proposed MIP-SPE procedure to spiked milk samples previous to the HPLC method for the detection of cephalosporins. The MIP-SPE recoveries were higher than 60% for the three target analytes in spiked milk.

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Authors+Show Affiliations

Quesada-Molina C
Institut de Chimie Organique et Analytique, CNRS FR 2708 UMR 6005, Université d'Orléans, 45067 Orléans, France.
Claude B
No affiliation info available
García-Campaña AM
No affiliation info available
del Olmo-Iruela M
No affiliation info available
Morin P
No affiliation info available

MeSH

AdsorptionAnimalsCattleFood ContaminationMethacrylatesMilkMolecular ImprintingPolymersSolid Phase Extraction

Pub Type(s)

Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22868158

Citation

Quesada-Molina, Carolina, et al. "Convenient Solid Phase Extraction of Cephalosporins in Milk Using a Molecularly Imprinted Polymer." Food Chemistry, vol. 135, no. 2, 2012, pp. 775-9.
Quesada-Molina C, Claude B, García-Campaña AM, et al. Convenient solid phase extraction of cephalosporins in milk using a molecularly imprinted polymer. Food Chem. 2012;135(2):775-9.
Quesada-Molina, C., Claude, B., García-Campaña, A. M., del Olmo-Iruela, M., & Morin, P. (2012). Convenient solid phase extraction of cephalosporins in milk using a molecularly imprinted polymer. Food Chemistry, 135(2), 775-9. https://doi.org/10.1016/j.foodchem.2012.05.014
Quesada-Molina C, et al. Convenient Solid Phase Extraction of Cephalosporins in Milk Using a Molecularly Imprinted Polymer. Food Chem. 2012 Nov 15;135(2):775-9. PubMed PMID: 22868158.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Convenient solid phase extraction of cephalosporins in milk using a molecularly imprinted polymer. AU - Quesada-Molina,Carolina, AU - Claude,Bérengère, AU - García-Campaña,Ana M, AU - del Olmo-Iruela,Monsalud, AU - Morin,Philippe, Y1 - 2012/05/11/ PY - 2010/12/22/received PY - 2011/12/13/revised PY - 2012/05/02/accepted PY - 2012/8/8/entrez PY - 2012/8/8/pubmed PY - 2012/12/10/medline SP - 775 EP - 9 JF - Food chemistry JO - Food Chem VL - 135 IS - 2 N2 - In this paper, a molecularly imprinted polymer (MIP) for cephalosporin molecules (cephalexin (CFL) and cephapirin (CFP)), was prepared by non covalent molecular imprinting approach and applied to solid phase extraction (SPE). For MIP synthesis, a tributylammonium cefadroxil salt (TBA-CFD) was used as template with methacrylic acid and ethylene glycol dimethacrylate as monomer and cross-linker, respectively, in acetone-methanol 92/8 (v/v) mixture. The selectivity of MIP versus non imprinted polymer (NIP) was confirmed for CFL, CFD and CFP in standard solutions as well as in milk samples. The efficiency of the synthesized MIP was evaluated by means of the application of the proposed MIP-SPE procedure to spiked milk samples previous to the HPLC method for the detection of cephalosporins. The MIP-SPE recoveries were higher than 60% for the three target analytes in spiked milk. SN - 1873-7072 UR - https://www.unboundmedicine.com/medline/citation/22868158/Convenient_solid_phase_extraction_of_cephalosporins_in_milk_using_a_molecularly_imprinted_polymer_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0308-8146(12)00835-7 DB - PRIME DP - Unbound Medicine ER -