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Morphometric comparison of foramen magnum in non-syndromic craniosynostosis patients with or without Chiari I malformation.
Acta Neurochir (Wien). 2012 Oct; 154(10):1809-13.AN

Abstract

BACKGROUND

In order to compare the morphometry of foramen magnum (FM) in a matched-pair study, in children with non-syndromic craniosynostosis with and without Chiari I malformation (CMI), both brain magnetic resonance (MRI) and multidetector computed tomography (MDCT) images were utilized.

METHODS

Brain MR images were retrieved from the Helsinki University Hospital Picture Archiving and Communications System to identify patients with CMI during 1.1.2004 to 31.3.2009. Age-, gender-, and craniosynostosis-matched controls were retrieved from the same cohort. Morphometric analysis of FM was carried out.

RESULTS

Seven patients with non-syndromic craniosynostosis with CMI were recorded. In CMI patients, the absolute anteroposterior length was 33.4 mm as compared to 36.7 mm in controls (p = 0.023). The mean width was 28.1 and 29.9 mm (p = 0.29), and the cross-sectional area was 654.1 and 764.9 mm(2) (p = 0.11) in CMI and controls, respectively. In CMI patients, the relative anteroposterior length of the FM was, on average, 91 % of the control's measurements. On average, the width was 95 % and the cross-sectional area was 88 % of the control's results.

CONCLUSIONS

In pediatric non-syndromic craniosynostosis patients, a statistically significant reduced anteroposterior diameter of the FM is found in patients with an adjacent CMI as compared to their age-, gender-, and type-matched controls of craniosynostosis.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Leikola J
Department of Plastic Surgery, Helsinki University Central Hospital, Helsinki, Finland. junnu.leikola@hus.fi
Haapamäki V
No affiliation info available
Karppinen A
No affiliation info available
Koljonen V
No affiliation info available
Hukki J
No affiliation info available
Valanne L
No affiliation info available
Koivikko M
No affiliation info available

MeSH

Arnold-Chiari MalformationChild, PreschoolCranial Fossa, PosteriorCraniosynostosesFemaleForamen MagnumHumansInfantMagnetic Resonance ImagingMale

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

22868492

Citation

Leikola, J, et al. "Morphometric Comparison of Foramen Magnum in Non-syndromic Craniosynostosis Patients With or Without Chiari I Malformation." Acta Neurochirurgica, vol. 154, no. 10, 2012, pp. 1809-13.
Leikola J, Haapamäki V, Karppinen A, et al. Morphometric comparison of foramen magnum in non-syndromic craniosynostosis patients with or without Chiari I malformation. Acta Neurochir (Wien). 2012;154(10):1809-13.
Leikola, J., Haapamäki, V., Karppinen, A., Koljonen, V., Hukki, J., Valanne, L., & Koivikko, M. (2012). Morphometric comparison of foramen magnum in non-syndromic craniosynostosis patients with or without Chiari I malformation. Acta Neurochirurgica, 154(10), 1809-13. https://doi.org/10.1007/s00701-012-1451-9
Leikola J, et al. Morphometric Comparison of Foramen Magnum in Non-syndromic Craniosynostosis Patients With or Without Chiari I Malformation. Acta Neurochir (Wien). 2012;154(10):1809-13. PubMed PMID: 22868492.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Morphometric comparison of foramen magnum in non-syndromic craniosynostosis patients with or without Chiari I malformation. AU - Leikola,J, AU - Haapamäki,V, AU - Karppinen,A, AU - Koljonen,V, AU - Hukki,J, AU - Valanne,L, AU - Koivikko,M, Y1 - 2012/08/07/ PY - 2012/05/15/received PY - 2012/07/09/accepted PY - 2012/8/8/entrez PY - 2012/8/8/pubmed PY - 2013/3/13/medline SP - 1809 EP - 13 JF - Acta neurochirurgica JO - Acta Neurochir (Wien) VL - 154 IS - 10 N2 - BACKGROUND: In order to compare the morphometry of foramen magnum (FM) in a matched-pair study, in children with non-syndromic craniosynostosis with and without Chiari I malformation (CMI), both brain magnetic resonance (MRI) and multidetector computed tomography (MDCT) images were utilized. METHODS: Brain MR images were retrieved from the Helsinki University Hospital Picture Archiving and Communications System to identify patients with CMI during 1.1.2004 to 31.3.2009. Age-, gender-, and craniosynostosis-matched controls were retrieved from the same cohort. Morphometric analysis of FM was carried out. RESULTS: Seven patients with non-syndromic craniosynostosis with CMI were recorded. In CMI patients, the absolute anteroposterior length was 33.4 mm as compared to 36.7 mm in controls (p = 0.023). The mean width was 28.1 and 29.9 mm (p = 0.29), and the cross-sectional area was 654.1 and 764.9 mm(2) (p = 0.11) in CMI and controls, respectively. In CMI patients, the relative anteroposterior length of the FM was, on average, 91 % of the control's measurements. On average, the width was 95 % and the cross-sectional area was 88 % of the control's results. CONCLUSIONS: In pediatric non-syndromic craniosynostosis patients, a statistically significant reduced anteroposterior diameter of the FM is found in patients with an adjacent CMI as compared to their age-, gender-, and type-matched controls of craniosynostosis. SN - 0942-0940 UR - https://www.unboundmedicine.com/medline/citation/22868492/Morphometric_comparison_of_foramen_magnum_in_non_syndromic_craniosynostosis_patients_with_or_without_Chiari_I_malformation_ DB - PRIME DP - Unbound Medicine ER -