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Factors influencing the prognosis of patients with intrahepatic cholangiocarcinoma.
Acta Gastroenterol Belg. 2012 Jun; 75(2):215-8.AG

Abstract

BACKGROUND AND AIMS

The outcome of surgical treatment of patients with intrahepatic cholangiocarcinoma (ICC) is poor. This study was designed to analyze prognostic factors following surgical treatment for ICC.

PATIENTS AND METHODS

A structured telephone interview was conducted in 132 patients who were surgically treated for ICC. Fifteen clinical and pathological factors that may influence post-operative survival were analyzed by using Cox proportional hazards model.

RESULTS

The accumulative 1-, 3-, 5-year survival rate of the 132 patients was 51.3%, 21.6%, and 11.8% respectively. The mean survival time in patients with elevated serum carbohydrate antigen (CA) 19-9 at the time of the operation was shorter than in patients with normal serum CA19-9 (9.6 +/- 24.7 vs 16.1 +/- 6 months, P < 0.01). The median survival time in patients with well-differentiated carcinoma was longer than in those with poorly differentiated ICC (23.9 +/- 7.8 vs. 11.2 +/- 5.0 months, P < 0.01). Patients who were treated with hepatectomy and lymph node dissection had a longer survival time than those treated with hepatectomy only (16.0 +/- 5.8 vs 10.2 +/- 3.6 months, P < 0.01). Multivariate analysis showed that mode of surgical treatment, lymph node metastasis, serum level of CA 19-9 and pathological differentiation grade of ICC predicted postoperative survival.

CONCLUSIONS

Hepatectomy with lymph node dissection is associated with an improved survival for patients with ICC. This strategy may be recommended for the surgical treatment of ICC.

Authors+Show Affiliations

Department of Hepatobiliary Surgery, Liaocheng People's Hospital and Liaocheng Clinical School of Taishan Medical University, Liaocheng, Shandong, 252000, P.R.China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22870785

Citation

Liu, Zhi-Heng, et al. "Factors Influencing the Prognosis of Patients With Intrahepatic Cholangiocarcinoma." Acta Gastro-enterologica Belgica, vol. 75, no. 2, 2012, pp. 215-8.
Liu ZH, Chen Z, Ma LL, et al. Factors influencing the prognosis of patients with intrahepatic cholangiocarcinoma. Acta Gastroenterol Belg. 2012;75(2):215-8.
Liu, Z. H., Chen, Z., Ma, L. L., Li, X. H., & Wang, L. X. (2012). Factors influencing the prognosis of patients with intrahepatic cholangiocarcinoma. Acta Gastro-enterologica Belgica, 75(2), 215-8.
Liu ZH, et al. Factors Influencing the Prognosis of Patients With Intrahepatic Cholangiocarcinoma. Acta Gastroenterol Belg. 2012;75(2):215-8. PubMed PMID: 22870785.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Factors influencing the prognosis of patients with intrahepatic cholangiocarcinoma. AU - Liu,Zhi-Heng, AU - Chen,Zhong, AU - Ma,Long-Le, AU - Li,Xue-Hua, AU - Wang,Le-Xin, PY - 2012/8/9/entrez PY - 2012/8/9/pubmed PY - 2012/10/12/medline SP - 215 EP - 8 JF - Acta gastro-enterologica Belgica JO - Acta Gastroenterol Belg VL - 75 IS - 2 N2 - BACKGROUND AND AIMS: The outcome of surgical treatment of patients with intrahepatic cholangiocarcinoma (ICC) is poor. This study was designed to analyze prognostic factors following surgical treatment for ICC. PATIENTS AND METHODS: A structured telephone interview was conducted in 132 patients who were surgically treated for ICC. Fifteen clinical and pathological factors that may influence post-operative survival were analyzed by using Cox proportional hazards model. RESULTS: The accumulative 1-, 3-, 5-year survival rate of the 132 patients was 51.3%, 21.6%, and 11.8% respectively. The mean survival time in patients with elevated serum carbohydrate antigen (CA) 19-9 at the time of the operation was shorter than in patients with normal serum CA19-9 (9.6 +/- 24.7 vs 16.1 +/- 6 months, P < 0.01). The median survival time in patients with well-differentiated carcinoma was longer than in those with poorly differentiated ICC (23.9 +/- 7.8 vs. 11.2 +/- 5.0 months, P < 0.01). Patients who were treated with hepatectomy and lymph node dissection had a longer survival time than those treated with hepatectomy only (16.0 +/- 5.8 vs 10.2 +/- 3.6 months, P < 0.01). Multivariate analysis showed that mode of surgical treatment, lymph node metastasis, serum level of CA 19-9 and pathological differentiation grade of ICC predicted postoperative survival. CONCLUSIONS: Hepatectomy with lymph node dissection is associated with an improved survival for patients with ICC. This strategy may be recommended for the surgical treatment of ICC. SN - 1784-3227 UR - https://www.unboundmedicine.com/medline/citation/22870785/Factors_influencing_the_prognosis_of_patients_with_intrahepatic_cholangiocarcinoma_ L2 - https://www.ageb.be/ageb-journal/ageb-volume/ageb-article/676 DB - PRIME DP - Unbound Medicine ER -