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The changes of blood platelet activation in breast cancer patients before surgery, after surgery, and in various phases of the chemotherapy.
Platelets 2013; 24(6):462-8P

Abstract

Blood platelets from patients with cancer (before or after the surgery) exhibit a variety of qualitative abnormalities. Different anti-cancer drugs may also induce the oxidative/nitrative stress in blood platelets and change their hemostatic properties. The aim of our study was to explain the effect of superoxide anion radicals ([Formula: see text]) production on hemostatic properties of blood platelets (activated by a strong physiological agonist - thrombin) from breast cancer patients before the surgery, after the surgery, and after various phases (I-IV) of chemotherapy (doxorubicin and cyclophosphamide). Patients were hospitalized in the Department of Oncological Surgery and at the Department of Chemotherapy, Medical University of Lodz, Poland. We measured the platelet aggregation as the marker of hemostatic activity of blood platelets. We observed an increase of [Formula: see text] in thrombin-activated blood platelets from patients with breast cancer (before or after the surgery and after various phases of the chemotherapy) compared to the healthy group. Our other experiments demonstrated that aggregation (induced by thrombin) of blood platelets from patients with breast cancer before the surgery, after the surgery, and after various phases of the chemotherapy differs from aggregation of platelets obtained from healthy volunteers. Moreover, our results showed the correlation between the [Formula: see text] generation and changes of platelet aggregation in breast cancer patients before the surgery, after the surgery, and after the chemotherapy (I and IV phases). Considering the data presented in this study, we suggest that the production of [Formula: see text] in blood platelets (activated by thrombin) obtained from breast cancer patients may induce the changes of platelet aggregation, which may contribute in thrombosis in these patients.

Authors+Show Affiliations

Department of General Biochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/3, 90-236, Lodz, Poland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22871094

Citation

Kedzierska, Magdalena, et al. "The Changes of Blood Platelet Activation in Breast Cancer Patients Before Surgery, After Surgery, and in Various Phases of the Chemotherapy." Platelets, vol. 24, no. 6, 2013, pp. 462-8.
Kedzierska M, Czernek U, Szydłowska-Pazera K, et al. The changes of blood platelet activation in breast cancer patients before surgery, after surgery, and in various phases of the chemotherapy. Platelets. 2013;24(6):462-8.
Kedzierska, M., Czernek, U., Szydłowska-Pazera, K., Potemski, P., Piekarski, J., Jeziorski, A., & Olas, B. (2013). The changes of blood platelet activation in breast cancer patients before surgery, after surgery, and in various phases of the chemotherapy. Platelets, 24(6), pp. 462-8. doi:10.3109/09537104.2012.711866.
Kedzierska M, et al. The Changes of Blood Platelet Activation in Breast Cancer Patients Before Surgery, After Surgery, and in Various Phases of the Chemotherapy. Platelets. 2013;24(6):462-8. PubMed PMID: 22871094.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The changes of blood platelet activation in breast cancer patients before surgery, after surgery, and in various phases of the chemotherapy. AU - Kedzierska,Magdalena, AU - Czernek,Urszula, AU - Szydłowska-Pazera,Katarzyna, AU - Potemski,Piotr, AU - Piekarski,Janusz, AU - Jeziorski,Arkadiusz, AU - Olas,Beata, Y1 - 2012/08/07/ PY - 2012/8/9/entrez PY - 2012/8/9/pubmed PY - 2014/2/25/medline SP - 462 EP - 8 JF - Platelets JO - Platelets VL - 24 IS - 6 N2 - Blood platelets from patients with cancer (before or after the surgery) exhibit a variety of qualitative abnormalities. Different anti-cancer drugs may also induce the oxidative/nitrative stress in blood platelets and change their hemostatic properties. The aim of our study was to explain the effect of superoxide anion radicals ([Formula: see text]) production on hemostatic properties of blood platelets (activated by a strong physiological agonist - thrombin) from breast cancer patients before the surgery, after the surgery, and after various phases (I-IV) of chemotherapy (doxorubicin and cyclophosphamide). Patients were hospitalized in the Department of Oncological Surgery and at the Department of Chemotherapy, Medical University of Lodz, Poland. We measured the platelet aggregation as the marker of hemostatic activity of blood platelets. We observed an increase of [Formula: see text] in thrombin-activated blood platelets from patients with breast cancer (before or after the surgery and after various phases of the chemotherapy) compared to the healthy group. Our other experiments demonstrated that aggregation (induced by thrombin) of blood platelets from patients with breast cancer before the surgery, after the surgery, and after various phases of the chemotherapy differs from aggregation of platelets obtained from healthy volunteers. Moreover, our results showed the correlation between the [Formula: see text] generation and changes of platelet aggregation in breast cancer patients before the surgery, after the surgery, and after the chemotherapy (I and IV phases). Considering the data presented in this study, we suggest that the production of [Formula: see text] in blood platelets (activated by thrombin) obtained from breast cancer patients may induce the changes of platelet aggregation, which may contribute in thrombosis in these patients. SN - 1369-1635 UR - https://www.unboundmedicine.com/medline/citation/22871094/The_changes_of_blood_platelet_activation_in_breast_cancer_patients_before_surgery_after_surgery_and_in_various_phases_of_the_chemotherapy_ L2 - http://www.tandfonline.com/doi/full/10.3109/09537104.2012.711866 DB - PRIME DP - Unbound Medicine ER -