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[Evaluation of the effectiveness of gastro-protected proteoferrin in the therapy of sideropenic anemia in childhood].
Minerva Pediatr. 1990 Sep; 42(9):343-7.MP

Abstract

The clinical efficacy and tolerability of gastroprotected ferritin were assessed in children affected by iron deficiency and/or sideropenic anemia. Forty-seven children with iron-deficiency and/or sideropenic anemia were included in the study and were treated with gastroprotected ferritin at a dose of 4-5 mg/kg/day per os for 4 months. Only 33 children correctly completed the entire treatment cycle, achieving a marked improvement of blood parameters (increased Hb, accompanied by higher levels of sideremia and in particular ferritin, with a contemporary decrease in erythrocytic protoporphyrin and transferrinemia) and clinical symptoms, especially pallor, anorexia, debility, somnolence, hyperactivity, disturbed sleep and excessive sweating. Of the remaining 14 children, 9 failed to present for the planned control after the 4 months of therapy, 3 abandoned therapy due to difficulties of assumption and 2 because of intolerance phenomena, such as nausea and diarrhoea. In conclusion, gastroprotected proteoferrin is efficacious and well tolerated in the treatment of iron deficiency in children.

Authors+Show Affiliations

Burattini MG
Istituto di Pediatria Clinica e Preventiva, Università di Bari.
Amendola F
No affiliation info available
Aufiero T
No affiliation info available
Spano M
No affiliation info available
Di Bitonto G
No affiliation info available
Del Vecchio GC
No affiliation info available
De Mattia D
No affiliation info available

MeSH

Anemia, HypochromicChildDrug EvaluationFerritinsHumansIron

Pub Type(s)

Clinical Trial
English Abstract
Journal Article
Review

Language

ita

PubMed ID

2287321

Citation

Burattini, M G., et al. "[Evaluation of the Effectiveness of Gastro-protected Proteoferrin in the Therapy of Sideropenic Anemia in Childhood]." Minerva Pediatrica, vol. 42, no. 9, 1990, pp. 343-7.
Burattini MG, Amendola F, Aufiero T, et al. [Evaluation of the effectiveness of gastro-protected proteoferrin in the therapy of sideropenic anemia in childhood]. Minerva Pediatr. 1990;42(9):343-7.
Burattini, M. G., Amendola, F., Aufiero, T., Spano, M., Di Bitonto, G., Del Vecchio, G. C., & De Mattia, D. (1990). [Evaluation of the effectiveness of gastro-protected proteoferrin in the therapy of sideropenic anemia in childhood]. Minerva Pediatrica, 42(9), 343-7.
Burattini MG, et al. [Evaluation of the Effectiveness of Gastro-protected Proteoferrin in the Therapy of Sideropenic Anemia in Childhood]. Minerva Pediatr. 1990;42(9):343-7. PubMed PMID: 2287321.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Evaluation of the effectiveness of gastro-protected proteoferrin in the therapy of sideropenic anemia in childhood]. AU - Burattini,M G, AU - Amendola,F, AU - Aufiero,T, AU - Spano,M, AU - Di Bitonto,G, AU - Del Vecchio,G C, AU - De Mattia,D, PY - 1990/9/1/pubmed PY - 1990/9/1/medline PY - 1990/9/1/entrez SP - 343 EP - 7 JF - Minerva pediatrica JO - Minerva Pediatr VL - 42 IS - 9 N2 - The clinical efficacy and tolerability of gastroprotected ferritin were assessed in children affected by iron deficiency and/or sideropenic anemia. Forty-seven children with iron-deficiency and/or sideropenic anemia were included in the study and were treated with gastroprotected ferritin at a dose of 4-5 mg/kg/day per os for 4 months. Only 33 children correctly completed the entire treatment cycle, achieving a marked improvement of blood parameters (increased Hb, accompanied by higher levels of sideremia and in particular ferritin, with a contemporary decrease in erythrocytic protoporphyrin and transferrinemia) and clinical symptoms, especially pallor, anorexia, debility, somnolence, hyperactivity, disturbed sleep and excessive sweating. Of the remaining 14 children, 9 failed to present for the planned control after the 4 months of therapy, 3 abandoned therapy due to difficulties of assumption and 2 because of intolerance phenomena, such as nausea and diarrhoea. In conclusion, gastroprotected proteoferrin is efficacious and well tolerated in the treatment of iron deficiency in children. SN - 0026-4946 UR - https://www.unboundmedicine.com/medline/citation/2287321/[Evaluation_of_the_effectiveness_of_gastro_protected_proteoferrin_in_the_therapy_of_sideropenic_anemia_in_childhood]_ DB - PRIME DP - Unbound Medicine ER -