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Enhanced renal Na+ reabsorption by carbohydrate in beverages during restitution from thermal and exercise-induced dehydration in men.

Abstract

We examined whether carbohydrate in beverages accelerated fluid retention during recovery from thermal and exercise-induced dehydration and whether it was caused in part by an enhanced renal Na+ reabsorption rate due to insulin secretion. After dehydrating by ∼2.3% body weight by exercise in a hot environment, seven young men underwent high-carbohydrate, low-carbohydrate, or control rehydration trials by drinking one of three beverages with 3.4 g glucose + 3.1 g fructose, 1.7 g glucose + 1.6 g fructose, or 0.0 g glucose + 0.0 g fructose per deciliter, respectively, in a common composition of electrolyte solution: 21 meq/l [Na+], 5 meq/l [K+], 16.5 meq/l [Cl-], 10 meq/l [citrate(-3)]. They drank the same amount of beverage as total body weight loss within 30 min. During the 60 min before the start of drinking and the following 180 min, we measured plasma volume (PV), plasma glucose ([Glc]p), serum insulin ([Ins]s), plasma Na+ concentrations, and the renal clearances of inulin, lithium, and Na+ with plasma vasopressin ([AVP]p) and aldosterone concentrations ([Ald]p) every 30 min. After dehydration, PV decreased by ∼5% and plasma osmolality increased by ∼6 mosmol/kg H2O in all trials with no significant differences among them. We found in the high-carbohydrate trial that 1) PV increased faster than in the control trial and remained at the higher level than other trials for the last 60 min (P < 0.05); 2) accumulated urine volume was smallest after 90 min (P < 0.05); 3) the renal Na+ reabsorption rate was greatest for the first 120 min (P < 0.05); 4) during which period [AVP]p and [Ald](p) were not significantly different from other trials (both, P > 0.9); and 5) [Glc](p) and [Ins]s were highest from 45 to 105 min (P < 0.05) during rehydration. Thus carbohydrate in beverages enhances renal Na+ reabsorption, and insulin is possibly involved in this enhancement.

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  • Authors+Show Affiliations

    ,

    Dept. of Sports Medical Sciences, Institute of Pathogenesis and Disease Prevention, Shinshu Univ. Graduate School of Medicine, Asahi 3-1-1, Matsumoto 390-8621, Japan.

    , , , , , ,

    Source

    MeSH

    Adult
    Aldosterone
    Analysis of Variance
    Beverages
    Bicycling
    Biomarkers
    Blood Glucose
    Dehydration
    Dietary Carbohydrates
    Environment
    Exercise
    Exercise Test
    Fructose
    Glomerular Filtration Rate
    Glucose
    Hot Temperature
    Humans
    Insulin
    Japan
    Kidney Tubules
    Least-Squares Analysis
    Male
    Natriuresis
    Neurophysins
    Osmolar Concentration
    Plasma Volume
    Protein Precursors
    Recovery of Function
    Rehydration Solutions
    Sodium
    Time Factors
    Urodynamics
    Vasopressins
    Water-Electrolyte Balance
    Young Adult

    Pub Type(s)

    Comparative Study
    Controlled Clinical Trial
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    22874424

    Citation

    Kamijo, Yoshi-Ichiro, et al. "Enhanced Renal Na+ Reabsorption By Carbohydrate in Beverages During Restitution From Thermal and Exercise-induced Dehydration in Men." American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, vol. 303, no. 8, 2012, pp. R824-33.
    Kamijo Y, Ikegawa S, Okada Y, et al. Enhanced renal Na+ reabsorption by carbohydrate in beverages during restitution from thermal and exercise-induced dehydration in men. Am J Physiol Regul Integr Comp Physiol. 2012;303(8):R824-33.
    Kamijo, Y., Ikegawa, S., Okada, Y., Masuki, S., Okazaki, K., Uchida, K., ... Nose, H. (2012). Enhanced renal Na+ reabsorption by carbohydrate in beverages during restitution from thermal and exercise-induced dehydration in men. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 303(8), pp. R824-33. doi:10.1152/ajpregu.00588.2011.
    Kamijo Y, et al. Enhanced Renal Na+ Reabsorption By Carbohydrate in Beverages During Restitution From Thermal and Exercise-induced Dehydration in Men. Am J Physiol Regul Integr Comp Physiol. 2012 Oct 15;303(8):R824-33. PubMed PMID: 22874424.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Enhanced renal Na+ reabsorption by carbohydrate in beverages during restitution from thermal and exercise-induced dehydration in men. AU - Kamijo,Yoshi-Ichiro, AU - Ikegawa,Shigeki, AU - Okada,Yoshiyuki, AU - Masuki,Shizue, AU - Okazaki,Kazunobu, AU - Uchida,Koji, AU - Sakurai,Masao, AU - Nose,Hiroshi, Y1 - 2012/08/08/ PY - 2012/8/10/entrez PY - 2012/8/10/pubmed PY - 2012/12/22/medline SP - R824 EP - 33 JF - American journal of physiology. Regulatory, integrative and comparative physiology JO - Am. J. Physiol. Regul. Integr. Comp. Physiol. VL - 303 IS - 8 N2 - We examined whether carbohydrate in beverages accelerated fluid retention during recovery from thermal and exercise-induced dehydration and whether it was caused in part by an enhanced renal Na+ reabsorption rate due to insulin secretion. After dehydrating by ∼2.3% body weight by exercise in a hot environment, seven young men underwent high-carbohydrate, low-carbohydrate, or control rehydration trials by drinking one of three beverages with 3.4 g glucose + 3.1 g fructose, 1.7 g glucose + 1.6 g fructose, or 0.0 g glucose + 0.0 g fructose per deciliter, respectively, in a common composition of electrolyte solution: 21 meq/l [Na+], 5 meq/l [K+], 16.5 meq/l [Cl-], 10 meq/l [citrate(-3)]. They drank the same amount of beverage as total body weight loss within 30 min. During the 60 min before the start of drinking and the following 180 min, we measured plasma volume (PV), plasma glucose ([Glc]p), serum insulin ([Ins]s), plasma Na+ concentrations, and the renal clearances of inulin, lithium, and Na+ with plasma vasopressin ([AVP]p) and aldosterone concentrations ([Ald]p) every 30 min. After dehydration, PV decreased by ∼5% and plasma osmolality increased by ∼6 mosmol/kg H2O in all trials with no significant differences among them. We found in the high-carbohydrate trial that 1) PV increased faster than in the control trial and remained at the higher level than other trials for the last 60 min (P < 0.05); 2) accumulated urine volume was smallest after 90 min (P < 0.05); 3) the renal Na+ reabsorption rate was greatest for the first 120 min (P < 0.05); 4) during which period [AVP]p and [Ald](p) were not significantly different from other trials (both, P > 0.9); and 5) [Glc](p) and [Ins]s were highest from 45 to 105 min (P < 0.05) during rehydration. Thus carbohydrate in beverages enhances renal Na+ reabsorption, and insulin is possibly involved in this enhancement. SN - 1522-1490 UR - https://www.unboundmedicine.com/medline/citation/22874424/Enhanced_renal_Na+_reabsorption_by_carbohydrate_in_beverages_during_restitution_from_thermal_and_exercise_induced_dehydration_in_men_ L2 - http://www.physiology.org/doi/full/10.1152/ajpregu.00588.2011?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -