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Enhanced renal Na+ reabsorption by carbohydrate in beverages during restitution from thermal and exercise-induced dehydration in men.
. 2012 Oct 15; 303(8):R824-33.

Abstract

We examined whether carbohydrate in beverages accelerated fluid retention during recovery from thermal and exercise-induced dehydration and whether it was caused in part by an enhanced renal Na+ reabsorption rate due to insulin secretion. After dehydrating by ∼2.3% body weight by exercise in a hot environment, seven young men underwent high-carbohydrate, low-carbohydrate, or control rehydration trials by drinking one of three beverages with 3.4 g glucose + 3.1 g fructose, 1.7 g glucose + 1.6 g fructose, or 0.0 g glucose + 0.0 g fructose per deciliter, respectively, in a common composition of electrolyte solution: 21 meq/l [Na+], 5 meq/l [K+], 16.5 meq/l [Cl-], 10 meq/l [citrate(-3)]. They drank the same amount of beverage as total body weight loss within 30 min. During the 60 min before the start of drinking and the following 180 min, we measured plasma volume (PV), plasma glucose ([Glc]p), serum insulin ([Ins]s), plasma Na+ concentrations, and the renal clearances of inulin, lithium, and Na+ with plasma vasopressin ([AVP]p) and aldosterone concentrations ([Ald]p) every 30 min. After dehydration, PV decreased by ∼5% and plasma osmolality increased by ∼6 mosmol/kg H2O in all trials with no significant differences among them. We found in the high-carbohydrate trial that 1) PV increased faster than in the control trial and remained at the higher level than other trials for the last 60 min (P < 0.05); 2) accumulated urine volume was smallest after 90 min (P < 0.05); 3) the renal Na+ reabsorption rate was greatest for the first 120 min (P < 0.05); 4) during which period [AVP]p and [Ald](p) were not significantly different from other trials (both, P > 0.9); and 5) [Glc](p) and [Ins]s were highest from 45 to 105 min (P < 0.05) during rehydration. Thus carbohydrate in beverages enhances renal Na+ reabsorption, and insulin is possibly involved in this enhancement.

Authors+Show Affiliations

Dept. of Sports Medical Sciences, Institute of Pathogenesis and Disease Prevention, Shinshu Univ. Graduate School of Medicine, Asahi 3-1-1, Matsumoto 390-8621, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22874424

Citation

Kamijo, Yoshi-Ichiro, et al. "Enhanced Renal Na+ Reabsorption By Carbohydrate in Beverages During Restitution From Thermal and Exercise-induced Dehydration in Men." American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, vol. 303, no. 8, 2012, pp. R824-33.
Kamijo Y, Ikegawa S, Okada Y, et al. Enhanced renal Na+ reabsorption by carbohydrate in beverages during restitution from thermal and exercise-induced dehydration in men. Am J Physiol Regul Integr Comp Physiol. 2012;303(8):R824-33.
Kamijo, Y., Ikegawa, S., Okada, Y., Masuki, S., Okazaki, K., Uchida, K., Sakurai, M., & Nose, H. (2012). Enhanced renal Na+ reabsorption by carbohydrate in beverages during restitution from thermal and exercise-induced dehydration in men. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 303(8), R824-33. https://doi.org/10.1152/ajpregu.00588.2011
Kamijo Y, et al. Enhanced Renal Na+ Reabsorption By Carbohydrate in Beverages During Restitution From Thermal and Exercise-induced Dehydration in Men. Am J Physiol Regul Integr Comp Physiol. 2012 Oct 15;303(8):R824-33. PubMed PMID: 22874424.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Enhanced renal Na+ reabsorption by carbohydrate in beverages during restitution from thermal and exercise-induced dehydration in men. AU - Kamijo,Yoshi-Ichiro, AU - Ikegawa,Shigeki, AU - Okada,Yoshiyuki, AU - Masuki,Shizue, AU - Okazaki,Kazunobu, AU - Uchida,Koji, AU - Sakurai,Masao, AU - Nose,Hiroshi, Y1 - 2012/08/08/ PY - 2012/8/10/entrez PY - 2012/8/10/pubmed PY - 2012/12/22/medline SP - R824 EP - 33 JF - American journal of physiology. Regulatory, integrative and comparative physiology JO - Am. J. Physiol. Regul. Integr. Comp. Physiol. VL - 303 IS - 8 N2 - We examined whether carbohydrate in beverages accelerated fluid retention during recovery from thermal and exercise-induced dehydration and whether it was caused in part by an enhanced renal Na+ reabsorption rate due to insulin secretion. After dehydrating by ∼2.3% body weight by exercise in a hot environment, seven young men underwent high-carbohydrate, low-carbohydrate, or control rehydration trials by drinking one of three beverages with 3.4 g glucose + 3.1 g fructose, 1.7 g glucose + 1.6 g fructose, or 0.0 g glucose + 0.0 g fructose per deciliter, respectively, in a common composition of electrolyte solution: 21 meq/l [Na+], 5 meq/l [K+], 16.5 meq/l [Cl-], 10 meq/l [citrate(-3)]. They drank the same amount of beverage as total body weight loss within 30 min. During the 60 min before the start of drinking and the following 180 min, we measured plasma volume (PV), plasma glucose ([Glc]p), serum insulin ([Ins]s), plasma Na+ concentrations, and the renal clearances of inulin, lithium, and Na+ with plasma vasopressin ([AVP]p) and aldosterone concentrations ([Ald]p) every 30 min. After dehydration, PV decreased by ∼5% and plasma osmolality increased by ∼6 mosmol/kg H2O in all trials with no significant differences among them. We found in the high-carbohydrate trial that 1) PV increased faster than in the control trial and remained at the higher level than other trials for the last 60 min (P < 0.05); 2) accumulated urine volume was smallest after 90 min (P < 0.05); 3) the renal Na+ reabsorption rate was greatest for the first 120 min (P < 0.05); 4) during which period [AVP]p and [Ald](p) were not significantly different from other trials (both, P > 0.9); and 5) [Glc](p) and [Ins]s were highest from 45 to 105 min (P < 0.05) during rehydration. Thus carbohydrate in beverages enhances renal Na+ reabsorption, and insulin is possibly involved in this enhancement. SN - 1522-1490 UR - https://www.unboundmedicine.com/medline/citation/22874424/Enhanced_renal_Na+_reabsorption_by_carbohydrate_in_beverages_during_restitution_from_thermal_and_exercise_induced_dehydration_in_men_ L2 - https://journals.physiology.org/doi/10.1152/ajpregu.00588.2011?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -