Tags

Type your tag names separated by a space and hit enter

Acid-base status and progression of chronic kidney disease.
Curr Opin Nephrol Hypertens. 2012 Sep; 21(5):552-6.CO

Abstract

PURPOSE OF REVIEW

Most patients with reduced glomerular filtration rate (GFR) have progressive GFR decline despite currently recommended kidney-protective interventions. Recent studies support that dietary acid reduction with Na(+)-based alkali or food types that yield base when metabolized provides kidney protection that is additive to currently recommended interventions. We review these recent studies in light of current kidney-protective recommendations for chronic kidney disease (CKD).

RECENT FINDINGS

Animal models of CKD show that metabolic acidosis and/or dietary acid induce intrakidney mechanisms that cause kidney injury and mediate progressive GFR decline. Translational studies in patients show that NaHCO(3) ameliorates kidney injury in patients with CKD and reduced GFR, with and without metabolic acidosis; NaHCO(3) and base-inducing food types each ameliorate kidney injury in patients with reduced GFR without metabolic acidosis; and NaHCO(3) and Na(+) citrate each slow GFR decline in CKD patients with reduced GFR, with and without metabolic acidosis.

SUMMARY

Recently published studies in animals and humans suggest that acid-base-related mechanisms mediate nephropathy progression. These studies support that dietary acid reduction with Na(+)-based alkali or alkali-inducing food is an effective kidney-protective adjunct to current strategies and support re-examination of current recommendations for CKD management.

Authors+Show Affiliations

Departments of Internal Medicine, Texas A&M Health Sciences Center College of Medicine, Temple, Texas, USA.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

22874469

Citation

Goraya, Nimrit, and Donald E. Wesson. "Acid-base Status and Progression of Chronic Kidney Disease." Current Opinion in Nephrology and Hypertension, vol. 21, no. 5, 2012, pp. 552-6.
Goraya N, Wesson DE. Acid-base status and progression of chronic kidney disease. Curr Opin Nephrol Hypertens. 2012;21(5):552-6.
Goraya, N., & Wesson, D. E. (2012). Acid-base status and progression of chronic kidney disease. Current Opinion in Nephrology and Hypertension, 21(5), 552-6. https://doi.org/10.1097/MNH.0b013e328356233b
Goraya N, Wesson DE. Acid-base Status and Progression of Chronic Kidney Disease. Curr Opin Nephrol Hypertens. 2012;21(5):552-6. PubMed PMID: 22874469.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acid-base status and progression of chronic kidney disease. AU - Goraya,Nimrit, AU - Wesson,Donald E, PY - 2012/8/10/entrez PY - 2012/8/10/pubmed PY - 2013/1/4/medline SP - 552 EP - 6 JF - Current opinion in nephrology and hypertension JO - Curr Opin Nephrol Hypertens VL - 21 IS - 5 N2 - PURPOSE OF REVIEW: Most patients with reduced glomerular filtration rate (GFR) have progressive GFR decline despite currently recommended kidney-protective interventions. Recent studies support that dietary acid reduction with Na(+)-based alkali or food types that yield base when metabolized provides kidney protection that is additive to currently recommended interventions. We review these recent studies in light of current kidney-protective recommendations for chronic kidney disease (CKD). RECENT FINDINGS: Animal models of CKD show that metabolic acidosis and/or dietary acid induce intrakidney mechanisms that cause kidney injury and mediate progressive GFR decline. Translational studies in patients show that NaHCO(3) ameliorates kidney injury in patients with CKD and reduced GFR, with and without metabolic acidosis; NaHCO(3) and base-inducing food types each ameliorate kidney injury in patients with reduced GFR without metabolic acidosis; and NaHCO(3) and Na(+) citrate each slow GFR decline in CKD patients with reduced GFR, with and without metabolic acidosis. SUMMARY: Recently published studies in animals and humans suggest that acid-base-related mechanisms mediate nephropathy progression. These studies support that dietary acid reduction with Na(+)-based alkali or alkali-inducing food is an effective kidney-protective adjunct to current strategies and support re-examination of current recommendations for CKD management. SN - 1473-6543 UR - https://www.unboundmedicine.com/medline/citation/22874469/Acid_base_status_and_progression_of_chronic_kidney_disease_ DB - PRIME DP - Unbound Medicine ER -