TY - JOUR T1 - A comprehensive pathophysiology of dandruff and seborrheic dermatitis - towards a more precise definition of scalp health. AU - Schwartz,James R, AU - Messenger,Andrew G, AU - Tosti,Antonella, AU - Todd,Gail, AU - Hordinsky,Maria, AU - Hay,Roderick J, AU - Wang,Xuemin, AU - Zachariae,Claus, AU - Kerr,Kathy M, AU - Henry,James P, AU - Rust,Rene C, AU - Robinson,Michael K, PY - 2012/8/10/entrez PY - 2012/8/10/pubmed PY - 2013/9/26/medline SP - 131 EP - 7 JF - Acta dermato-venereologica JO - Acta Derm Venereol VL - 93 IS - 2 N2 - Despite an increasing knowledge of dandruff and seborrheic dermatitis (D/SD), the pathophysiological understanding is still incomplete but suggests a role of Malassezia yeasts in triggering inflammatory and hyper-proliferative epidermal responses. The objective of this report is to review published literature from in vivo studies of D/SD populations to provide a more complete description of overall scalp health. New biomolecular capabilities establish a depth of pathophysiological understanding not previously achievable with traditional means of investigation. Biomarkers representing inflammation, hyper-proliferation and barrier function are all perturbed by the D/SD condition and robustly respond to therapeutic resolution. These biomarkers can be sampled noninvasively, enabling their use in routine clinical evaluations as either surrogate endpoints or complementary ones to classical signs/symptoms to broaden the etiological learning. SN - 1651-2057 UR - https://www.unboundmedicine.com/medline/citation/22875203/A_comprehensive_pathophysiology_of_dandruff_and_seborrheic_dermatitis___towards_a_more_precise_definition_of_scalp_health_ L2 - https://www.medicaljournals.se/acta/content/abstract/10.2340/00015555-1382 DB - PRIME DP - Unbound Medicine ER -