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Impact of environmental and dietary factors on the course of inflammatory bowel disease.
World J Gastroenterol 2012; 18(29):3814-22WJ

Abstract

Besides their possible effects on the development of inflammatory bowel disease (IBD), some environmental factors can modulate the clinical course of both ulcerative colitis (UC) and Crohn's disease (CD). This review is mainly devoted to describing the current knowledge of the impact of some of these factors on the outcome of IBD, with special emphasis on smoking and diet. Although the impact of smoking on the susceptibility to develop CD and UC is firmly established, its influence on the clinical course of both diseases is still debatable. In CD, active smoking is a risk factor for postoperative recurrence. Beyond this clinical setting, smoking cessation seems to be advantageous in those CD patients who were smokers at disease diagnosis, while smoking resumption may be of benefit in ex-smokers with resistant UC. The role of dietary habits on the development of IBD is far from being well established. Also, food intolerances are very frequent, but usually inconsistent among IBD patients, and therefore no general dietary recommendations can be made in these patients. In general, IBD patients should eat a diet as varied as possible. Regarding the possible therapeutic role of some dietary components in IBD, lessons should be drawn from the investigation of the primary therapeutic effect of enteral nutrition in CD. Low-fat diets seem to be particularly useful. Also, some lipid sources, such as olive oil, medium-chain triglycerides, and perhaps omega-3 fatty acids, might have a therapeutic effect. Fermentable fiber may have a role in preventing relapses in inactive UC.

Authors+Show Affiliations

Inflammatory Bowel Disease Unit, Department of Gastroenterology, Hospital Universitari Germans Trias i Pujol, Badalona, Spain. ecabre.germanstrias@gencat.cat

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

22876032

Citation

Cabré, Eduard, and Eugeni Domènech. "Impact of Environmental and Dietary Factors On the Course of Inflammatory Bowel Disease." World Journal of Gastroenterology, vol. 18, no. 29, 2012, pp. 3814-22.
Cabré E, Domènech E. Impact of environmental and dietary factors on the course of inflammatory bowel disease. World J Gastroenterol. 2012;18(29):3814-22.
Cabré, E., & Domènech, E. (2012). Impact of environmental and dietary factors on the course of inflammatory bowel disease. World Journal of Gastroenterology, 18(29), pp. 3814-22. doi:10.3748/wjg.v18.i29.3814.
Cabré E, Domènech E. Impact of Environmental and Dietary Factors On the Course of Inflammatory Bowel Disease. World J Gastroenterol. 2012 Aug 7;18(29):3814-22. PubMed PMID: 22876032.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of environmental and dietary factors on the course of inflammatory bowel disease. AU - Cabré,Eduard, AU - Domènech,Eugeni, PY - 2012/02/06/received PY - 2012/03/26/revised PY - 2012/03/29/accepted PY - 2012/8/10/entrez PY - 2012/8/10/pubmed PY - 2013/1/12/medline KW - Dietary factors KW - Environmental factors KW - Infections KW - Inflammatory bowel disease KW - Nonsteroidal anti-inflammatory drugs KW - Smoking SP - 3814 EP - 22 JF - World journal of gastroenterology JO - World J. Gastroenterol. VL - 18 IS - 29 N2 - Besides their possible effects on the development of inflammatory bowel disease (IBD), some environmental factors can modulate the clinical course of both ulcerative colitis (UC) and Crohn's disease (CD). This review is mainly devoted to describing the current knowledge of the impact of some of these factors on the outcome of IBD, with special emphasis on smoking and diet. Although the impact of smoking on the susceptibility to develop CD and UC is firmly established, its influence on the clinical course of both diseases is still debatable. In CD, active smoking is a risk factor for postoperative recurrence. Beyond this clinical setting, smoking cessation seems to be advantageous in those CD patients who were smokers at disease diagnosis, while smoking resumption may be of benefit in ex-smokers with resistant UC. The role of dietary habits on the development of IBD is far from being well established. Also, food intolerances are very frequent, but usually inconsistent among IBD patients, and therefore no general dietary recommendations can be made in these patients. In general, IBD patients should eat a diet as varied as possible. Regarding the possible therapeutic role of some dietary components in IBD, lessons should be drawn from the investigation of the primary therapeutic effect of enteral nutrition in CD. Low-fat diets seem to be particularly useful. Also, some lipid sources, such as olive oil, medium-chain triglycerides, and perhaps omega-3 fatty acids, might have a therapeutic effect. Fermentable fiber may have a role in preventing relapses in inactive UC. SN - 2219-2840 UR - https://www.unboundmedicine.com/medline/citation/22876032/Impact_of_environmental_and_dietary_factors_on_the_course_of_inflammatory_bowel_disease_ L2 - http://www.wjgnet.com/1007-9327/full/v18/i29/3814.htm DB - PRIME DP - Unbound Medicine ER -