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Gum Ghatti--a pharmaceutical excipient: development, evaluation and optimization of sustained release mucoadhesive matrix tablets of domperidone.
Acta Pol Pharm. 2012 Jul-Aug; 69(4):725-37.AP

Abstract

The objective of this study was to extend the GI residence time of the dosage form and to control the release of domperidone using directly compressible sustained release mucoadhesive matrix (SRMM) tablets. A 2-factor centre composite design (CCD) was employed to study the influence of independent variables like gum ghatti (GG) (X1) and hydroxylpropylmethyl cellulose K 15M (HPMC K 15M) (X2) on dependent variable like mucoadhesive strength, tensile strength, release exponent (n), t50 (time for 50% drug release), rel(10 h) (release after 10 h) and rel(18 h) (release after 18 h). Tablets were prepared by direct compression technology and evaluated for tablet parametric test (drug assay, diameter, thickness, hardness and tensile strength), mucoadhesive strength (using texture analyzer) and in vitro drug release studies. The tensile strength and mucoadhesive strength were found to be increased from 0.665 +/- 0.1 to 1.591 +/- 0.1 MN/cm2 (Z1 to Z9) and 10.789 +/- 0.985 to 50.924 +/- 1.150 N (Z1 to Z9), respectively. The release kinetics follows first order and Hixson Crowell equation indicating drug release following combination of diffusion and erosion. The n varies between 0.834 and 1.273, indicating release mechanism shifts from non fickian (anomalous release) to super case II, which depict that drug follows multiple drug release mechanism. The t50 time was found to increase from 5 +/- 0.12 to 11.4 +/- 0.14 h (Z1 to Z9) and release after 10 and 18 h decreases with increasing concentration of both polymers concluding with release controlling potential of polymers. The accelerated stability studies were performed on optimized formulation as per ICH guideline and the result showed that there was no significant change in tensile strength, mucoadhesive strength and drug assay.

Authors+Show Affiliations

School of Pharmaceutical Sciences, Chitkara University, Solan-174103 (HP), India.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article

Language

eng

PubMed ID

22876617

Citation

Gurpreetarora, , et al. "Gum Ghatti--a Pharmaceutical Excipient: Development, Evaluation and Optimization of Sustained Release Mucoadhesive Matrix Tablets of Domperidone." Acta Poloniae Pharmaceutica, vol. 69, no. 4, 2012, pp. 725-37.
Gurpreetarora , Malik K, Rana V, et al. Gum Ghatti--a pharmaceutical excipient: development, evaluation and optimization of sustained release mucoadhesive matrix tablets of domperidone. Acta Pol Pharm. 2012;69(4):725-37.
Gurpreetarora, ., Malik, K., Rana, V., & Singh, I. (2012). Gum Ghatti--a pharmaceutical excipient: development, evaluation and optimization of sustained release mucoadhesive matrix tablets of domperidone. Acta Poloniae Pharmaceutica, 69(4), 725-37.
Gurpreetarora , et al. Gum Ghatti--a Pharmaceutical Excipient: Development, Evaluation and Optimization of Sustained Release Mucoadhesive Matrix Tablets of Domperidone. Acta Pol Pharm. 2012 Jul-Aug;69(4):725-37. PubMed PMID: 22876617.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gum Ghatti--a pharmaceutical excipient: development, evaluation and optimization of sustained release mucoadhesive matrix tablets of domperidone. AU - Gurpreetarora,, AU - Malik,Karan, AU - Rana,Vikas, AU - Singh,Inderbir, PY - 2012/8/11/entrez PY - 2012/8/11/pubmed PY - 2012/8/29/medline SP - 725 EP - 37 JF - Acta poloniae pharmaceutica JO - Acta Pol Pharm VL - 69 IS - 4 N2 - The objective of this study was to extend the GI residence time of the dosage form and to control the release of domperidone using directly compressible sustained release mucoadhesive matrix (SRMM) tablets. A 2-factor centre composite design (CCD) was employed to study the influence of independent variables like gum ghatti (GG) (X1) and hydroxylpropylmethyl cellulose K 15M (HPMC K 15M) (X2) on dependent variable like mucoadhesive strength, tensile strength, release exponent (n), t50 (time for 50% drug release), rel(10 h) (release after 10 h) and rel(18 h) (release after 18 h). Tablets were prepared by direct compression technology and evaluated for tablet parametric test (drug assay, diameter, thickness, hardness and tensile strength), mucoadhesive strength (using texture analyzer) and in vitro drug release studies. The tensile strength and mucoadhesive strength were found to be increased from 0.665 +/- 0.1 to 1.591 +/- 0.1 MN/cm2 (Z1 to Z9) and 10.789 +/- 0.985 to 50.924 +/- 1.150 N (Z1 to Z9), respectively. The release kinetics follows first order and Hixson Crowell equation indicating drug release following combination of diffusion and erosion. The n varies between 0.834 and 1.273, indicating release mechanism shifts from non fickian (anomalous release) to super case II, which depict that drug follows multiple drug release mechanism. The t50 time was found to increase from 5 +/- 0.12 to 11.4 +/- 0.14 h (Z1 to Z9) and release after 10 and 18 h decreases with increasing concentration of both polymers concluding with release controlling potential of polymers. The accelerated stability studies were performed on optimized formulation as per ICH guideline and the result showed that there was no significant change in tensile strength, mucoadhesive strength and drug assay. SN - 0001-6837 UR - https://www.unboundmedicine.com/medline/citation/22876617/Gum_Ghatti__a_pharmaceutical_excipient:_development_evaluation_and_optimization_of_sustained_release_mucoadhesive_matrix_tablets_of_domperidone_ L2 - http://www.ptfarm.pl/pub/File/Acta_Poloniae/2012/4/725.pdf DB - PRIME DP - Unbound Medicine ER -