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Relationship between blood lipid profiles and pancreatic islet β cell function in Chinese men and women with normal glucose tolerance: a cross-sectional study.
BMC Public Health. 2012 Aug 10; 12:634.BP

Abstract

BACKGROUND

Dyslipidemia is present in people with diabetes as well as subjects with normal glucose tolerance (NGT). The purpose of this study was to investigate the relationship between lipid profiles and β cell function in Chinese individuals with NGT but without history of diabetes or prediabetes.

METHODS

A total of 893 men and 1454 women aged 18-76 years living in Sichuan, China, who were not being treated with lipid-lowering drugs were enrolled in this study. Insulin sensitivity (IR) was evaluated using the homeostasis model assessment -IR (HOMA-IR), β-cell function was calculated by the following equation: ΔI30/ΔG30/ HOMA-IR (ΔI30/ΔG30: the ratio of incremental glucose and insulin 30 min after glucose intake). Multivariate linear regression analyses were performed to estimate the relationship between blood lipid and β cell function as standardized coefficients (β).

RESULTS

β cell function decreased in men and women with increasing age. We found inverse relationships between β cell function and total cholesterol (TC) in men and women (β = -0.157 and -0.113, respectively, both p < 0.001), low-density lipoprotein-cholesterol (LDL-C; β = -0.130 and -0.068, respectively, both p < 0.001), TC/high-density lipoprotein-cholesterol (HDL-C) ratio (β = -0.084, p < 0.01 and -0.096, p < 0.001), and triglycerides (TG) (women only; β = -0.053, p < 0.05). However, β cell function was not associated with HDL-C in men or women (β = -0.034 and 0.000, respectively, both p > 0.05) or the TG/HDL-C ratio (β = -0.035 and -0.013, respectively, both p > 0.05). β cell function was significantly worse in males than in females in all age groups, except in subjects aged > 70 years.

CONCLUSIONS

Dyslipidemia is associated with dysfunction of pancreatic β cells in subjects with NGT and this is particularly evident in people with elevated TC and LDL-C levels, especially males.

TRIAL REGISTRATION NUMBER

#TR-CCH-Chi CTR-CCH-00000361.

Authors+Show Affiliations

Department of Endocrinology and Metabolism, West China Hospital of Sichuan University, Chengdu, 610041, People's Republic of China.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22876749

Citation

Zheng, Tianpeng, et al. "Relationship Between Blood Lipid Profiles and Pancreatic Islet Β Cell Function in Chinese Men and Women With Normal Glucose Tolerance: a Cross-sectional Study." BMC Public Health, vol. 12, 2012, p. 634.
Zheng T, Gao Y, Tian H. Relationship between blood lipid profiles and pancreatic islet β cell function in Chinese men and women with normal glucose tolerance: a cross-sectional study. BMC Public Health. 2012;12:634.
Zheng, T., Gao, Y., & Tian, H. (2012). Relationship between blood lipid profiles and pancreatic islet β cell function in Chinese men and women with normal glucose tolerance: a cross-sectional study. BMC Public Health, 12, 634. https://doi.org/10.1186/1471-2458-12-634
Zheng T, Gao Y, Tian H. Relationship Between Blood Lipid Profiles and Pancreatic Islet Β Cell Function in Chinese Men and Women With Normal Glucose Tolerance: a Cross-sectional Study. BMC Public Health. 2012 Aug 10;12:634. PubMed PMID: 22876749.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between blood lipid profiles and pancreatic islet β cell function in Chinese men and women with normal glucose tolerance: a cross-sectional study. AU - Zheng,Tianpeng, AU - Gao,Yun, AU - Tian,Haoming, Y1 - 2012/08/10/ PY - 2012/04/04/received PY - 2012/07/30/accepted PY - 2012/8/11/entrez PY - 2012/8/11/pubmed PY - 2013/4/23/medline SP - 634 EP - 634 JF - BMC public health JO - BMC Public Health VL - 12 N2 - BACKGROUND: Dyslipidemia is present in people with diabetes as well as subjects with normal glucose tolerance (NGT). The purpose of this study was to investigate the relationship between lipid profiles and β cell function in Chinese individuals with NGT but without history of diabetes or prediabetes. METHODS: A total of 893 men and 1454 women aged 18-76 years living in Sichuan, China, who were not being treated with lipid-lowering drugs were enrolled in this study. Insulin sensitivity (IR) was evaluated using the homeostasis model assessment -IR (HOMA-IR), β-cell function was calculated by the following equation: ΔI30/ΔG30/ HOMA-IR (ΔI30/ΔG30: the ratio of incremental glucose and insulin 30 min after glucose intake). Multivariate linear regression analyses were performed to estimate the relationship between blood lipid and β cell function as standardized coefficients (β). RESULTS: β cell function decreased in men and women with increasing age. We found inverse relationships between β cell function and total cholesterol (TC) in men and women (β = -0.157 and -0.113, respectively, both p < 0.001), low-density lipoprotein-cholesterol (LDL-C; β = -0.130 and -0.068, respectively, both p < 0.001), TC/high-density lipoprotein-cholesterol (HDL-C) ratio (β = -0.084, p < 0.01 and -0.096, p < 0.001), and triglycerides (TG) (women only; β = -0.053, p < 0.05). However, β cell function was not associated with HDL-C in men or women (β = -0.034 and 0.000, respectively, both p > 0.05) or the TG/HDL-C ratio (β = -0.035 and -0.013, respectively, both p > 0.05). β cell function was significantly worse in males than in females in all age groups, except in subjects aged > 70 years. CONCLUSIONS: Dyslipidemia is associated with dysfunction of pancreatic β cells in subjects with NGT and this is particularly evident in people with elevated TC and LDL-C levels, especially males. TRIAL REGISTRATION NUMBER: #TR-CCH-Chi CTR-CCH-00000361. SN - 1471-2458 UR - https://www.unboundmedicine.com/medline/citation/22876749/Relationship_between_blood_lipid_profiles_and_pancreatic_islet_β_cell_function_in_Chinese_men_and_women_with_normal_glucose_tolerance:_a_cross_sectional_study_ L2 - https://bmcpublichealth.biomedcentral.com/articles/10.1186/1471-2458-12-634 DB - PRIME DP - Unbound Medicine ER -