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[Long-term outcome analysis in the treatment of granulosa cell tumors].

Abstract

INTRODUCTION

Granulosa cell tumors of the ovary (GCT) are derived from the sex cords and the ovarian stroma. Their natural history however is indolent with a very favorable long-term prognosis. Their extreme rarity represents a limitation in our understanding of their natural history management, and prognosis.

MATERIAL AND METHODS

Retrospective analysis of patient documentation treated for GCT between 1988-2008 at the Maria Skłodowska-Curie Memorial Cancer Centre, Warsaw, was performed. Clinical and pathological features of the study group, as well as methods and results of the treatment were analyzed.

RESULTS

Medical documentation of 148 patients was analyzed. The majority of patients was classified as FIGO stage 1 (87.5%). Surgery was performed as primary treatment in all cases. Forty eight patients (32,6%) were held for observation stays, whereas 57.1% were qualified to receive adjuvant treatment: chemo- or radiotherapy. Mean progression free survival was 133.5 months (11.1 years) and was significantly longer in patients treated with the chemotherapy regimen when compared to radiotherapy (148 vs. 91 months respectively; p = 0.028). Overall survival was 173,7 months and was significantly longer in patients treated with adjuvant chemotherapy vs. RTH (165 vs. 121 months; p = 0.068). Recurrence of the disease was associated with poorer prognosis.

CONCLUSIONS

GCTs are potentially curable neoplasms of the ovary with low treatment failure rates. Quick diagnosis and appropriate treatment in centers experienced in ovarian cancer surgery are the necessary conditions to obtain good results. The stage of the disease remains the most important prognostic factor chemotherapy with the use of bleomycine etoposide and cisplatin should be considered in patients who require adjuvant treatment.

Links

Authors+Show Affiliations

,

Katedra i Klinika Połoznictwa, Chorób Kobiecych i Ginekologii Onkologicznej II WL WUM, Warszawa, Polska. kuba.rzepka@gmail.com

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Source

Ginekologia polska 83:7 2012 Jul pg 505-10

MeSH

Adult
Age Factors
Aged
Aged, 80 and over
Antineoplastic Combined Chemotherapy Protocols
Chemotherapy, Adjuvant
Female
Granulosa Cell Tumor
Gynecologic Surgical Procedures
Humans
Middle Aged
Neoplasm Staging
Ovarian Neoplasms
Poland
Retrospective Studies
Survival Analysis
Treatment Outcome
Women's Health
Young Adult

Pub Type(s)

English Abstract
Journal Article

Language

pol

PubMed ID

22880474

Citation

Rzepka, Jakub, et al. "[Long-term Outcome Analysis in the Treatment of Granulosa Cell Tumors]." Ginekologia Polska, vol. 83, no. 7, 2012, pp. 505-10.
Rzepka J, Kuc-Rajca M, Zalewski K, et al. [Long-term outcome analysis in the treatment of granulosa cell tumors]. Ginekol Pol. 2012;83(7):505-10.
Rzepka, J., Kuc-Rajca, M., Zalewski, K., Dańska-Bidzińska, A., & Bidziński, M. (2012). [Long-term outcome analysis in the treatment of granulosa cell tumors]. Ginekologia Polska, 83(7), pp. 505-10.
Rzepka J, et al. [Long-term Outcome Analysis in the Treatment of Granulosa Cell Tumors]. Ginekol Pol. 2012;83(7):505-10. PubMed PMID: 22880474.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Long-term outcome analysis in the treatment of granulosa cell tumors]. AU - Rzepka,Jakub, AU - Kuc-Rajca,Małgorzata, AU - Zalewski,Kamil, AU - Dańska-Bidzińska,Anna, AU - Bidziński,Mariusz, PY - 2012/8/14/entrez PY - 2012/8/14/pubmed PY - 2012/9/7/medline SP - 505 EP - 10 JF - Ginekologia polska JO - Ginekol. Pol. VL - 83 IS - 7 N2 - INTRODUCTION: Granulosa cell tumors of the ovary (GCT) are derived from the sex cords and the ovarian stroma. Their natural history however is indolent with a very favorable long-term prognosis. Their extreme rarity represents a limitation in our understanding of their natural history management, and prognosis. MATERIAL AND METHODS: Retrospective analysis of patient documentation treated for GCT between 1988-2008 at the Maria Skłodowska-Curie Memorial Cancer Centre, Warsaw, was performed. Clinical and pathological features of the study group, as well as methods and results of the treatment were analyzed. RESULTS: Medical documentation of 148 patients was analyzed. The majority of patients was classified as FIGO stage 1 (87.5%). Surgery was performed as primary treatment in all cases. Forty eight patients (32,6%) were held for observation stays, whereas 57.1% were qualified to receive adjuvant treatment: chemo- or radiotherapy. Mean progression free survival was 133.5 months (11.1 years) and was significantly longer in patients treated with the chemotherapy regimen when compared to radiotherapy (148 vs. 91 months respectively; p = 0.028). Overall survival was 173,7 months and was significantly longer in patients treated with adjuvant chemotherapy vs. RTH (165 vs. 121 months; p = 0.068). Recurrence of the disease was associated with poorer prognosis. CONCLUSIONS: GCTs are potentially curable neoplasms of the ovary with low treatment failure rates. Quick diagnosis and appropriate treatment in centers experienced in ovarian cancer surgery are the necessary conditions to obtain good results. The stage of the disease remains the most important prognostic factor chemotherapy with the use of bleomycine etoposide and cisplatin should be considered in patients who require adjuvant treatment. SN - 0017-0011 UR - https://www.unboundmedicine.com/medline/citation/22880474/[Long_term_outcome_analysis_in_the_treatment_of_granulosa_cell_tumors]_ L2 - https://medlineplus.gov/ovariancancer.html DB - PRIME DP - Unbound Medicine ER -