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Reducing effect of mangiferin on serum uric acid levels in mice.
Pharm Biol. 2012 Sep; 50(9):1177-82.PB

Abstract

CONTEXT

Mangiferin, a natural bioactive xanthone C-glycoside, is widely present in medicinal plants like the leaf of Mangifera indica L. (Anacardiaceae). It has been reported that mangiferin possesses a variety of biological activities, including antidiabetic, hepatoprotective, anti-inflammatory, antioxidant, and anticarcinogenic.

OBJECTIVE

The hypouricemic effect and xanthine oxidoreductase (XOR) inhibitory activity of mangiferin were investigated here for the first time.

MATERIALS AND METHODS

The hypouricemic effect of mangiferin was investigated in normal and hyperuricemic mice induced by potassium oxonate. Mangiferin at a dose of 0.75-100.0 mg/kg was given intragastrically to mice. The serum urate levels were determined using the phosphotungstic acid method. The hepatic activities of xanthine dehydrogenase (XDH) and xanthine oxidase (XOD) in hyperuricemic mice were assayed using commercially available kits.

RESULTS

The results showed that mangiferin at a dose of 1.5, 3.0, and 6.0 mg/kg significantly reduced the serum urate levels (148.7 ± 37.8, 142.2 ± 44.5, 121.7 ± 21.7 µmmol/L) in hyperuricemic mice, compared with untreated hyperuricemic mice (201.8 ± 71.2 µmmol/L). However, mangiferin did not decrease the serum urate levels in normal mice until mangiferin was up to 100 mg/kg. In addition, the hepatic activities of XDH in hyperuricemic mice were significantly decreased by mangiferin, while no changes of XOD were observed. Acute toxicity study in mice showed that mangiferin was very safe at a dose of up to 25 g/kg.

DISCUSSION AND CONCLUSION

These findings demonstrate that mangiferin has the potential to be developed as a new therapeutic agent for the treatment of hyperuricemia and gout.

Authors+Show Affiliations

Biomedical Engineering Research Center, Kunming Medical University, Kunming, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22881143

Citation

Niu, Yanfen, et al. "Reducing Effect of Mangiferin On Serum Uric Acid Levels in Mice." Pharmaceutical Biology, vol. 50, no. 9, 2012, pp. 1177-82.
Niu Y, Lu W, Gao L, et al. Reducing effect of mangiferin on serum uric acid levels in mice. Pharm Biol. 2012;50(9):1177-82.
Niu, Y., Lu, W., Gao, L., Lin, H., Liu, X., & Li, L. (2012). Reducing effect of mangiferin on serum uric acid levels in mice. Pharmaceutical Biology, 50(9), 1177-82. https://doi.org/10.3109/13880209.2012.663763
Niu Y, et al. Reducing Effect of Mangiferin On Serum Uric Acid Levels in Mice. Pharm Biol. 2012;50(9):1177-82. PubMed PMID: 22881143.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reducing effect of mangiferin on serum uric acid levels in mice. AU - Niu,Yanfen, AU - Lu,Wei, AU - Gao,Lihui, AU - Lin,Hua, AU - Liu,Xu, AU - Li,Ling, PY - 2012/8/14/entrez PY - 2012/8/14/pubmed PY - 2013/4/26/medline SP - 1177 EP - 82 JF - Pharmaceutical biology JO - Pharm Biol VL - 50 IS - 9 N2 - CONTEXT: Mangiferin, a natural bioactive xanthone C-glycoside, is widely present in medicinal plants like the leaf of Mangifera indica L. (Anacardiaceae). It has been reported that mangiferin possesses a variety of biological activities, including antidiabetic, hepatoprotective, anti-inflammatory, antioxidant, and anticarcinogenic. OBJECTIVE: The hypouricemic effect and xanthine oxidoreductase (XOR) inhibitory activity of mangiferin were investigated here for the first time. MATERIALS AND METHODS: The hypouricemic effect of mangiferin was investigated in normal and hyperuricemic mice induced by potassium oxonate. Mangiferin at a dose of 0.75-100.0 mg/kg was given intragastrically to mice. The serum urate levels were determined using the phosphotungstic acid method. The hepatic activities of xanthine dehydrogenase (XDH) and xanthine oxidase (XOD) in hyperuricemic mice were assayed using commercially available kits. RESULTS: The results showed that mangiferin at a dose of 1.5, 3.0, and 6.0 mg/kg significantly reduced the serum urate levels (148.7 ± 37.8, 142.2 ± 44.5, 121.7 ± 21.7 µmmol/L) in hyperuricemic mice, compared with untreated hyperuricemic mice (201.8 ± 71.2 µmmol/L). However, mangiferin did not decrease the serum urate levels in normal mice until mangiferin was up to 100 mg/kg. In addition, the hepatic activities of XDH in hyperuricemic mice were significantly decreased by mangiferin, while no changes of XOD were observed. Acute toxicity study in mice showed that mangiferin was very safe at a dose of up to 25 g/kg. DISCUSSION AND CONCLUSION: These findings demonstrate that mangiferin has the potential to be developed as a new therapeutic agent for the treatment of hyperuricemia and gout. SN - 1744-5116 UR - https://www.unboundmedicine.com/medline/citation/22881143/Reducing_effect_of_mangiferin_on_serum_uric_acid_levels_in_mice_ L2 - http://www.tandfonline.com/doi/full/10.3109/13880209.2012.663763 DB - PRIME DP - Unbound Medicine ER -