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[Diagnosis and prevalence of latent hepatic encephalopathy].
Z Gastroenterol 1990; 28(11):610-5ZG

Abstract

To compare the efficacy of various psychometric and neurophysiological tests in the detection of latent hepatic encephalopathy (LHE) cerebral functions were studied in 146 patients with liver cirrhosis but without overt encephalopathy and in 146 matched controls. Patients with liver cirrhosis scored significantly worse than controls in 8 out of 11 tests. Best discrimination between patients with cirrhosis and controls was obtained by testing for reaction time to white and colored light with a reaction time apparatus (DTG), and with the digit symbol (UT1) and block design test (UT4), i.e. with two Wechsler adult intelligence scale performance tests. Thirtyseven out of 146 (25%) patients with cirrhosis reveiled an abnormal result with the DTG alone. A combination of the DTG, UT1 and UT4 yielded the diagnosis in 44 (30%) patients. LHE correlated with the severity of the disease (Child-Pugh classification) but not with its etiology or with portasystemic shunting. In the Federal Republic of Germany about 300,000 subjects suffer from liver cirrhosis. Based on our results 100,000 of them may have LHE.

Authors+Show Affiliations

Klinik Föhrenkamp der BfA, Mölln.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

ger

PubMed ID

2288139

Citation

Koch, H, et al. "[Diagnosis and Prevalence of Latent Hepatic Encephalopathy]." Zeitschrift Fur Gastroenterologie, vol. 28, no. 11, 1990, pp. 610-5.
Koch H, Schauder P, Schäfer G, et al. [Diagnosis and prevalence of latent hepatic encephalopathy]. Z Gastroenterol. 1990;28(11):610-5.
Koch, H., Schauder, P., Schäfer, G., Dahme, B., Ebel, W., Vahldiek, B., ... Henning, H. (1990). [Diagnosis and prevalence of latent hepatic encephalopathy]. Zeitschrift Fur Gastroenterologie, 28(11), pp. 610-5.
Koch H, et al. [Diagnosis and Prevalence of Latent Hepatic Encephalopathy]. Z Gastroenterol. 1990;28(11):610-5. PubMed PMID: 2288139.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Diagnosis and prevalence of latent hepatic encephalopathy]. AU - Koch,H, AU - Schauder,P, AU - Schäfer,G, AU - Dahme,B, AU - Ebel,W, AU - Vahldiek,B, AU - König,F, AU - Henning,H, PY - 1990/11/1/pubmed PY - 1990/11/1/medline PY - 1990/11/1/entrez SP - 610 EP - 5 JF - Zeitschrift fur Gastroenterologie JO - Z Gastroenterol VL - 28 IS - 11 N2 - To compare the efficacy of various psychometric and neurophysiological tests in the detection of latent hepatic encephalopathy (LHE) cerebral functions were studied in 146 patients with liver cirrhosis but without overt encephalopathy and in 146 matched controls. Patients with liver cirrhosis scored significantly worse than controls in 8 out of 11 tests. Best discrimination between patients with cirrhosis and controls was obtained by testing for reaction time to white and colored light with a reaction time apparatus (DTG), and with the digit symbol (UT1) and block design test (UT4), i.e. with two Wechsler adult intelligence scale performance tests. Thirtyseven out of 146 (25%) patients with cirrhosis reveiled an abnormal result with the DTG alone. A combination of the DTG, UT1 and UT4 yielded the diagnosis in 44 (30%) patients. LHE correlated with the severity of the disease (Child-Pugh classification) but not with its etiology or with portasystemic shunting. In the Federal Republic of Germany about 300,000 subjects suffer from liver cirrhosis. Based on our results 100,000 of them may have LHE. SN - 0044-2771 UR - https://www.unboundmedicine.com/medline/citation/2288139/[Diagnosis_and_prevalence_of_latent_hepatic_encephalopathy]_ L2 - http://www.diseaseinfosearch.org/result/3328 DB - PRIME DP - Unbound Medicine ER -