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Characterising surface energy of pharmaceutical powders by inverse gas chromatography at finite dilution.
J Pharm Pharmacol. 2012 Sep; 64(9):1337-48.JP

Abstract

OBJECTIVES

The objectives of this project were the use of surface energy distributions in: distinguishing the effects of magnesium stearate on the surface energy of lactose processed by two methods: mixing in a Turbula and mechanofusion; characterising surface energy of materials before and after micronisation; and understanding surface energy changes of micronised lactose before and after storage at high relative humidity (RH).

METHODS

Heptane, octane and nonane were used to determine nonpolar surface energy, and dichloromethane and ethyl acetate were used to determine polar surface energy in inverse gas chromatography at finite dilution.

KEY FINDINGS

The total surface energy of lactose decreased more after mechanofusion with magnesium stearate than mixing in Turbula. The nonpolar surface energy of indometacin increased while polar and total surface energies decreased after micronisation. The nonpolar, polar and total surface energies and work of cohesion of micronised lactose decreased after storage at 75% RH for three months.

CONCLUSIONS

The surface energy distributions determined at finite dilution successfully distinguished and revealed more information than infinite dilution on surface energy changes in materials undergoing different pharmaceutical processes such as mixing, mechanofusion, micronisation and storage at high RH.

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Authors+Show Affiliations

Das SC
Faculty of Pharmacy and Pharmaceutical Sciences, Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia. shyamal.das@monash.edu
Stewart PJ
No affiliation info available

MeSH

Administration, InhalationAerosolsAnti-Inflammatory Agents, Non-SteroidalChemical PhenomenaChromatography, GasDrug CompoundingDrug Delivery SystemsDrug StorageDry Powder InhalersExcipientsHumansIndomethacinLactoseMicroscopy, Electron, ScanningOsmolar ConcentrationParticle SizePowdersSolventsStearic AcidsSurface Properties

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22881445

Citation

Das, Shyamal C., and Peter J. Stewart. "Characterising Surface Energy of Pharmaceutical Powders By Inverse Gas Chromatography at Finite Dilution." The Journal of Pharmacy and Pharmacology, vol. 64, no. 9, 2012, pp. 1337-48.
Das SC, Stewart PJ. Characterising surface energy of pharmaceutical powders by inverse gas chromatography at finite dilution. J Pharm Pharmacol. 2012;64(9):1337-48.
Das, S. C., & Stewart, P. J. (2012). Characterising surface energy of pharmaceutical powders by inverse gas chromatography at finite dilution. The Journal of Pharmacy and Pharmacology, 64(9), 1337-48. https://doi.org/10.1111/j.2042-7158.2012.01533.x
Das SC, Stewart PJ. Characterising Surface Energy of Pharmaceutical Powders By Inverse Gas Chromatography at Finite Dilution. J Pharm Pharmacol. 2012;64(9):1337-48. PubMed PMID: 22881445.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characterising surface energy of pharmaceutical powders by inverse gas chromatography at finite dilution. AU - Das,Shyamal C, AU - Stewart,Peter J, Y1 - 2012/05/09/ PY - 2012/8/14/entrez PY - 2012/8/14/pubmed PY - 2013/1/12/medline SP - 1337 EP - 48 JF - The Journal of pharmacy and pharmacology JO - J Pharm Pharmacol VL - 64 IS - 9 N2 - OBJECTIVES: The objectives of this project were the use of surface energy distributions in: distinguishing the effects of magnesium stearate on the surface energy of lactose processed by two methods: mixing in a Turbula and mechanofusion; characterising surface energy of materials before and after micronisation; and understanding surface energy changes of micronised lactose before and after storage at high relative humidity (RH). METHODS: Heptane, octane and nonane were used to determine nonpolar surface energy, and dichloromethane and ethyl acetate were used to determine polar surface energy in inverse gas chromatography at finite dilution. KEY FINDINGS: The total surface energy of lactose decreased more after mechanofusion with magnesium stearate than mixing in Turbula. The nonpolar surface energy of indometacin increased while polar and total surface energies decreased after micronisation. The nonpolar, polar and total surface energies and work of cohesion of micronised lactose decreased after storage at 75% RH for three months. CONCLUSIONS: The surface energy distributions determined at finite dilution successfully distinguished and revealed more information than infinite dilution on surface energy changes in materials undergoing different pharmaceutical processes such as mixing, mechanofusion, micronisation and storage at high RH. SN - 2042-7158 UR - https://www.unboundmedicine.com/medline/citation/22881445/Characterising_surface_energy_of_pharmaceutical_powders_by_inverse_gas_chromatography_at_finite_dilution_ L2 - https://doi.org/10.1111/j.2042-7158.2012.01533.x DB - PRIME DP - Unbound Medicine ER -