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Evaluation of co-processed excipients used for direct compression of orally disintegrating tablets (ODT) using novel disintegration apparatus.
Pharm Dev Technol. 2013 Mar-Apr; 18(2):464-74.PD

Abstract

The compendial method of evaluation of orodispersible tablets (ODT) is the same disintegration test as for conventional tablets. Since it does not reflect the disintegration process in the oral cavity, alternative methods are proposed that are more related to in vivo conditions, e.g. modified dissolution paddle apparatus, texture analyzer, rotating shaft apparatus, CCD camera application, or wetting time and water absorption ratio measurement. In this study, three different co-processed excipients for direct compression of orally disintegrating tablets were compared (Ludiflash, Pharmaburst, F-Melt). The properties of the prepared tablets such as tensile strength, friability, wetting time and water absorption ratio were evaluated. Disintegration time was measured using the pharmacopoeial method and the novel apparatus constructed by the authors. The apparatus was based on the idea of Narazaki et al., however it has been modified. Magnetic resonance imaging (MRI) was applied for the analysis of the disintegration mechanism of prepared tablets. The research has shown the significant effect of excipients, compression force, temperature, volume and kind of medium on the disintegration process. The novel apparatus features better correlation of disintegration time with in vivo results (R(2) = 0.9999) than the compendial method (R(2) = 0.5788), and presents additional information on the disintegration process, e.g. swelling properties.

Authors+Show Affiliations

Department of Pharmaceutical Technology and Biopharmaceutics, Jagiellonian University Medical College, Krakow, Poland. w.brniak@cm-uj.krakow.plNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22881600

Citation

Brniak, Witold, et al. "Evaluation of Co-processed Excipients Used for Direct Compression of Orally Disintegrating Tablets (ODT) Using Novel Disintegration Apparatus." Pharmaceutical Development and Technology, vol. 18, no. 2, 2013, pp. 464-74.
Brniak W, Jachowicz R, Krupa A, et al. Evaluation of co-processed excipients used for direct compression of orally disintegrating tablets (ODT) using novel disintegration apparatus. Pharm Dev Technol. 2013;18(2):464-74.
Brniak, W., Jachowicz, R., Krupa, A., Skorka, T., & Niwinski, K. (2013). Evaluation of co-processed excipients used for direct compression of orally disintegrating tablets (ODT) using novel disintegration apparatus. Pharmaceutical Development and Technology, 18(2), 464-74. https://doi.org/10.3109/10837450.2012.710238
Brniak W, et al. Evaluation of Co-processed Excipients Used for Direct Compression of Orally Disintegrating Tablets (ODT) Using Novel Disintegration Apparatus. Pharm Dev Technol. 2013 Mar-Apr;18(2):464-74. PubMed PMID: 22881600.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of co-processed excipients used for direct compression of orally disintegrating tablets (ODT) using novel disintegration apparatus. AU - Brniak,Witold, AU - Jachowicz,Renata, AU - Krupa,Anna, AU - Skorka,Tomasz, AU - Niwinski,Krzysztof, Y1 - 2012/08/13/ PY - 2012/8/14/entrez PY - 2012/8/14/pubmed PY - 2013/7/9/medline SP - 464 EP - 74 JF - Pharmaceutical development and technology JO - Pharm Dev Technol VL - 18 IS - 2 N2 - The compendial method of evaluation of orodispersible tablets (ODT) is the same disintegration test as for conventional tablets. Since it does not reflect the disintegration process in the oral cavity, alternative methods are proposed that are more related to in vivo conditions, e.g. modified dissolution paddle apparatus, texture analyzer, rotating shaft apparatus, CCD camera application, or wetting time and water absorption ratio measurement. In this study, three different co-processed excipients for direct compression of orally disintegrating tablets were compared (Ludiflash, Pharmaburst, F-Melt). The properties of the prepared tablets such as tensile strength, friability, wetting time and water absorption ratio were evaluated. Disintegration time was measured using the pharmacopoeial method and the novel apparatus constructed by the authors. The apparatus was based on the idea of Narazaki et al., however it has been modified. Magnetic resonance imaging (MRI) was applied for the analysis of the disintegration mechanism of prepared tablets. The research has shown the significant effect of excipients, compression force, temperature, volume and kind of medium on the disintegration process. The novel apparatus features better correlation of disintegration time with in vivo results (R(2) = 0.9999) than the compendial method (R(2) = 0.5788), and presents additional information on the disintegration process, e.g. swelling properties. SN - 1097-9867 UR - https://www.unboundmedicine.com/medline/citation/22881600/Evaluation_of_co_processed_excipients_used_for_direct_compression_of_orally_disintegrating_tablets__ODT__using_novel_disintegration_apparatus_ L2 - https://www.tandfonline.com/doi/full/10.3109/10837450.2012.710238 DB - PRIME DP - Unbound Medicine ER -