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Association of the miR-146aC>G, miR-149T>C, miR-196a2T>C, and miR-499A>G polymorphisms with risk of spontaneously aborted fetuses.
Am J Reprod Immunol. 2012 Nov; 68(5):408-17.AJ

Abstract

PROBLEM

The miR-196a2T>C and miR-499A>G polymorphisms have been reported to be genetic risk factors for recurrent spontaneous abortion; however, that previous study focused on the genetic analyses of pregnant women rather than aborted fetuses. Because annexin A1 is a target of miR-196a2 and is related to anti-inflammation, miR-196a2 may be immunologically important. Moreover, miR-146a, miR-149, miR-196a2, and miR-499 have shown associations with immune responses.

METHOD OF STUDY

One hundred and eighty-two spontaneously aborted fetuses (SAFs) were <20 weeks of gestational age. The control subjects were 101 healthy children and 302 adults collected from a convenience sample. Polymerase chain reaction and restriction fragment length polymorphism analysis was performed to identify the miR-146aC>G, miR-149T>C, miR-196a2T>C, and miR-499A>G genotypes.

RESULTS

Chromosomally normal SAFs had significantly different frequencies of the miR-196a2CC, miR-146aCC/miR-196a2CC, and miR-149TT/miR-196a2CC genotypes compared with control subjects.

CONCLUSIONS

miR-196a2CC, miR-146aCC/miR-196a2CC, and miR-149TT/miR-196a2CC in fetuses are possible risk factors for spontaneous abortion.

Authors+Show Affiliations

Institute for Clinical Research, CHA Bundang Medical Center, CHA University, Seongnam, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22882355

Citation

Jeon, Young Joo, et al. "Association of the miR-146aC>G, miR-149T>C, miR-196a2T>C, and miR-499A>G Polymorphisms With Risk of Spontaneously Aborted Fetuses." American Journal of Reproductive Immunology (New York, N.Y. : 1989), vol. 68, no. 5, 2012, pp. 408-17.
Jeon YJ, Kim SY, Rah H, et al. Association of the miR-146aC>G, miR-149T>C, miR-196a2T>C, and miR-499A>G polymorphisms with risk of spontaneously aborted fetuses. Am J Reprod Immunol. 2012;68(5):408-17.
Jeon, Y. J., Kim, S. Y., Rah, H., Choi, D. H., Cha, S. H., Yoon, T. K., Lee, W. S., Shim, S. H., & Kim, N. K. (2012). Association of the miR-146aC>G, miR-149T>C, miR-196a2T>C, and miR-499A>G polymorphisms with risk of spontaneously aborted fetuses. American Journal of Reproductive Immunology (New York, N.Y. : 1989), 68(5), 408-17. https://doi.org/10.1111/aji.12005
Jeon YJ, et al. Association of the miR-146aC>G, miR-149T>C, miR-196a2T>C, and miR-499A>G Polymorphisms With Risk of Spontaneously Aborted Fetuses. Am J Reprod Immunol. 2012;68(5):408-17. PubMed PMID: 22882355.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of the miR-146aC>G, miR-149T>C, miR-196a2T>C, and miR-499A>G polymorphisms with risk of spontaneously aborted fetuses. AU - Jeon,Young Joo, AU - Kim,Su Yeoun, AU - Rah,HyungChul, AU - Choi,Dong Hee, AU - Cha,Sun Hee, AU - Yoon,Tae Ki, AU - Lee,Woo Sik, AU - Shim,Sung Han, AU - Kim,Nam Keun, Y1 - 2012/08/13/ PY - 2012/03/08/received PY - 2012/07/12/accepted PY - 2012/8/14/entrez PY - 2012/8/14/pubmed PY - 2013/3/9/medline SP - 408 EP - 17 JF - American journal of reproductive immunology (New York, N.Y. : 1989) JO - Am J Reprod Immunol VL - 68 IS - 5 N2 - PROBLEM: The miR-196a2T>C and miR-499A>G polymorphisms have been reported to be genetic risk factors for recurrent spontaneous abortion; however, that previous study focused on the genetic analyses of pregnant women rather than aborted fetuses. Because annexin A1 is a target of miR-196a2 and is related to anti-inflammation, miR-196a2 may be immunologically important. Moreover, miR-146a, miR-149, miR-196a2, and miR-499 have shown associations with immune responses. METHOD OF STUDY: One hundred and eighty-two spontaneously aborted fetuses (SAFs) were <20 weeks of gestational age. The control subjects were 101 healthy children and 302 adults collected from a convenience sample. Polymerase chain reaction and restriction fragment length polymorphism analysis was performed to identify the miR-146aC>G, miR-149T>C, miR-196a2T>C, and miR-499A>G genotypes. RESULTS: Chromosomally normal SAFs had significantly different frequencies of the miR-196a2CC, miR-146aCC/miR-196a2CC, and miR-149TT/miR-196a2CC genotypes compared with control subjects. CONCLUSIONS: miR-196a2CC, miR-146aCC/miR-196a2CC, and miR-149TT/miR-196a2CC in fetuses are possible risk factors for spontaneous abortion. SN - 1600-0897 UR - https://www.unboundmedicine.com/medline/citation/22882355/Association_of_the_miR_146aC>G_miR_149T>C_miR_196a2T>C_and_miR_499A>G_polymorphisms_with_risk_of_spontaneously_aborted_fetuses_ L2 - https://doi.org/10.1111/aji.12005 DB - PRIME DP - Unbound Medicine ER -