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GC-MS analysis and screening of antidiabetic, antioxidant and hypolipidemic potential of Cinnamomum tamala oil in streptozotocin induced diabetes mellitus in rats.
Cardiovasc Diabetol. 2012 Aug 10; 11:95.CD

Abstract

AIM OF THE STUDY

This study was made to investigate the antidiabetic, antioxidant and hypolipidemic potential of Cinnamomum tamala, (Buch.-Ham.) Nees & Eberm (Tejpat) oil (CTO) in streptozotocin (STZ) induced diabetes in rats along with evaluation of chemical constituents.

MATERIALS AND METHODS

The GC-MS (Gas chromatography-mass spectrometry) analysis of the oil showed 31 constituents of which cinnamaldehyde was found the major component (44.898%). CTO and cinnamaldehyde was orally administered to diabetic rats to study its effect in both acute and chronic antihyperglycemic models. The body weight, oral glucose tolerance test and biochemical parameters viz. glucose level, insulin level, liver glycogen content, glycosylated hemoglobin, total plasma cholesterol, triglyceride and antioxidant parameters were estimated for all treated groups and compared against diabetic control group.

RESULTS

CTO (100 mg/kg and 200 mg/kg), cinnamaldehyde (20 mg/kg) and glibenclamide (0.6 mg/kg) in respective groups of diabetic animals administered for 28 days reduced the blood glucose level in streptozotocin induced diabetic rats. There was significant increase in body weight, liver glycogen content, plasma insulin level and decrease in the blood glucose, glycosylated hemoglobin and total plasma cholesterol in test groups as compared to control group. The results of CTO and cinnamaldehyde were found comparable with standard drug glibenclamide. In vitro antioxidant studies on CTO using various models showed significant antioxidant activity. In vivo antioxidant studies on STZ induced diabetic rats revealed decreased malondialdehyde (MDA) and increased reduced glutathione (GSH).

CONCLUSION

Thus the investigation results that CTO has significant antidiabetic, antioxidant and hypolipidemic activity.

Authors+Show Affiliations

Pharmacology Division, Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Post Box: 38, Hisar, 125001, India.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22882757

Citation

Kumar, Suresh, et al. "GC-MS Analysis and Screening of Antidiabetic, Antioxidant and Hypolipidemic Potential of Cinnamomum Tamala Oil in Streptozotocin Induced Diabetes Mellitus in Rats." Cardiovascular Diabetology, vol. 11, 2012, p. 95.
Kumar S, Vasudeva N, Sharma S. GC-MS analysis and screening of antidiabetic, antioxidant and hypolipidemic potential of Cinnamomum tamala oil in streptozotocin induced diabetes mellitus in rats. Cardiovasc Diabetol. 2012;11:95.
Kumar, S., Vasudeva, N., & Sharma, S. (2012). GC-MS analysis and screening of antidiabetic, antioxidant and hypolipidemic potential of Cinnamomum tamala oil in streptozotocin induced diabetes mellitus in rats. Cardiovascular Diabetology, 11, 95. https://doi.org/10.1186/1475-2840-11-95
Kumar S, Vasudeva N, Sharma S. GC-MS Analysis and Screening of Antidiabetic, Antioxidant and Hypolipidemic Potential of Cinnamomum Tamala Oil in Streptozotocin Induced Diabetes Mellitus in Rats. Cardiovasc Diabetol. 2012 Aug 10;11:95. PubMed PMID: 22882757.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - GC-MS analysis and screening of antidiabetic, antioxidant and hypolipidemic potential of Cinnamomum tamala oil in streptozotocin induced diabetes mellitus in rats. AU - Kumar,Suresh, AU - Vasudeva,Neeru, AU - Sharma,Sunil, Y1 - 2012/08/10/ PY - 2012/07/24/received PY - 2012/08/07/accepted PY - 2012/8/14/entrez PY - 2012/8/14/pubmed PY - 2012/12/22/medline SP - 95 EP - 95 JF - Cardiovascular diabetology JO - Cardiovasc Diabetol VL - 11 N2 - AIM OF THE STUDY: This study was made to investigate the antidiabetic, antioxidant and hypolipidemic potential of Cinnamomum tamala, (Buch.-Ham.) Nees & Eberm (Tejpat) oil (CTO) in streptozotocin (STZ) induced diabetes in rats along with evaluation of chemical constituents. MATERIALS AND METHODS: The GC-MS (Gas chromatography-mass spectrometry) analysis of the oil showed 31 constituents of which cinnamaldehyde was found the major component (44.898%). CTO and cinnamaldehyde was orally administered to diabetic rats to study its effect in both acute and chronic antihyperglycemic models. The body weight, oral glucose tolerance test and biochemical parameters viz. glucose level, insulin level, liver glycogen content, glycosylated hemoglobin, total plasma cholesterol, triglyceride and antioxidant parameters were estimated for all treated groups and compared against diabetic control group. RESULTS: CTO (100 mg/kg and 200 mg/kg), cinnamaldehyde (20 mg/kg) and glibenclamide (0.6 mg/kg) in respective groups of diabetic animals administered for 28 days reduced the blood glucose level in streptozotocin induced diabetic rats. There was significant increase in body weight, liver glycogen content, plasma insulin level and decrease in the blood glucose, glycosylated hemoglobin and total plasma cholesterol in test groups as compared to control group. The results of CTO and cinnamaldehyde were found comparable with standard drug glibenclamide. In vitro antioxidant studies on CTO using various models showed significant antioxidant activity. In vivo antioxidant studies on STZ induced diabetic rats revealed decreased malondialdehyde (MDA) and increased reduced glutathione (GSH). CONCLUSION: Thus the investigation results that CTO has significant antidiabetic, antioxidant and hypolipidemic activity. SN - 1475-2840 UR - https://www.unboundmedicine.com/medline/citation/22882757/GC_MS_analysis_and_screening_of_antidiabetic_antioxidant_and_hypolipidemic_potential_of_Cinnamomum_tamala_oil_in_streptozotocin_induced_diabetes_mellitus_in_rats_ L2 - https://cardiab.biomedcentral.com/articles/10.1186/1475-2840-11-95 DB - PRIME DP - Unbound Medicine ER -