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Aberrant intrinsic brain activity and cognitive deficit in first-episode treatment-naive patients with schizophrenia.
Psychol Med 2013; 43(4):769-80PM

Abstract

BACKGROUND

Given the important role of the default mode network (DMN) in cognitive function and the well-known neurocognitive deficit in schizophrenia, it is intriguing to examine systematically the relationship between neurocognitive dysfunction and aberrant intrinsic activities, and also functional connectivity, of the DMN in patients with schizophrenia. Method First-episode, treatment-naive patients with schizophrenia (FES) (n = 115) and healthy controls (n = 113) underwent resting-state functional magnetic resonance imaging (fMRI) scans and neurocognitive tests. Intrinsic neural activities evaluated by using the fragment amplitude of low-frequency fluctuations (fALFF) and the resting-state functional connectivity assessed by seed-based correlational analysis were compared between patients and controls. Aberrant intrinsic activities and DMN connectivity in patients were then correlated to neurocognitive performance and clinical symptoms.

RESULTS

Compared to controls, patients with FES showed decreased fALFF in the bilateral medial prefrontal cortex (MPFC) and the orbitofrontal cortex (OFC), and increased fALFF in the bilateral putamen. Increased functional connectivity with the DMN was observed in the left insula and bilateral dorsolateral PFC (DLPFC) in patients with FES. In patients, aberrant fALFF in the bilateral OFC were correlated with cognitive processing speed; fALFF in the left OFC and right putamen were correlated with the clinical factors excited/activation and disorganization; and increased DMN functional connectivity in the left insula was correlated with the clinical factors positive, excited/activation, disorganization and neurocognitive deficit in the domain of sustained attention.

CONCLUSIONS

These associations between neurocognitive dysfunction and aberrant intrinsic activities, and also functional connectivity, of the DMN in patients with schizophrenia may provide important insights into the neural mechanism of the disease.

Authors+Show Affiliations

The Mental Health Center and the Psychiatric Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22883428

Citation

He, Z, et al. "Aberrant Intrinsic Brain Activity and Cognitive Deficit in First-episode Treatment-naive Patients With Schizophrenia." Psychological Medicine, vol. 43, no. 4, 2013, pp. 769-80.
He Z, Deng W, Li M, et al. Aberrant intrinsic brain activity and cognitive deficit in first-episode treatment-naive patients with schizophrenia. Psychol Med. 2013;43(4):769-80.
He, Z., Deng, W., Li, M., Chen, Z., Jiang, L., Wang, Q., ... Li, T. (2013). Aberrant intrinsic brain activity and cognitive deficit in first-episode treatment-naive patients with schizophrenia. Psychological Medicine, 43(4), pp. 769-80. doi:10.1017/S0033291712001638.
He Z, et al. Aberrant Intrinsic Brain Activity and Cognitive Deficit in First-episode Treatment-naive Patients With Schizophrenia. Psychol Med. 2013;43(4):769-80. PubMed PMID: 22883428.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Aberrant intrinsic brain activity and cognitive deficit in first-episode treatment-naive patients with schizophrenia. AU - He,Z, AU - Deng,W, AU - Li,M, AU - Chen,Z, AU - Jiang,L, AU - Wang,Q, AU - Huang,C, AU - Collier,D A, AU - Gong,Q, AU - Ma,X, AU - Zhang,N, AU - Li,T, Y1 - 2012/08/10/ PY - 2012/8/14/entrez PY - 2012/8/14/pubmed PY - 2013/9/21/medline SP - 769 EP - 80 JF - Psychological medicine JO - Psychol Med VL - 43 IS - 4 N2 - BACKGROUND: Given the important role of the default mode network (DMN) in cognitive function and the well-known neurocognitive deficit in schizophrenia, it is intriguing to examine systematically the relationship between neurocognitive dysfunction and aberrant intrinsic activities, and also functional connectivity, of the DMN in patients with schizophrenia. Method First-episode, treatment-naive patients with schizophrenia (FES) (n = 115) and healthy controls (n = 113) underwent resting-state functional magnetic resonance imaging (fMRI) scans and neurocognitive tests. Intrinsic neural activities evaluated by using the fragment amplitude of low-frequency fluctuations (fALFF) and the resting-state functional connectivity assessed by seed-based correlational analysis were compared between patients and controls. Aberrant intrinsic activities and DMN connectivity in patients were then correlated to neurocognitive performance and clinical symptoms. RESULTS: Compared to controls, patients with FES showed decreased fALFF in the bilateral medial prefrontal cortex (MPFC) and the orbitofrontal cortex (OFC), and increased fALFF in the bilateral putamen. Increased functional connectivity with the DMN was observed in the left insula and bilateral dorsolateral PFC (DLPFC) in patients with FES. In patients, aberrant fALFF in the bilateral OFC were correlated with cognitive processing speed; fALFF in the left OFC and right putamen were correlated with the clinical factors excited/activation and disorganization; and increased DMN functional connectivity in the left insula was correlated with the clinical factors positive, excited/activation, disorganization and neurocognitive deficit in the domain of sustained attention. CONCLUSIONS: These associations between neurocognitive dysfunction and aberrant intrinsic activities, and also functional connectivity, of the DMN in patients with schizophrenia may provide important insights into the neural mechanism of the disease. SN - 1469-8978 UR - https://www.unboundmedicine.com/medline/citation/22883428/Aberrant_intrinsic_brain_activity_and_cognitive_deficit_in_first_episode_treatment_naive_patients_with_schizophrenia_ L2 - https://www.cambridge.org/core/product/identifier/S0033291712001638/type/journal_article DB - PRIME DP - Unbound Medicine ER -