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[Clinical characteristics and diagnosis of pulmonary mucosa-associated lymphoid tissue-derived (MALT) lymphoma: a retrospective analysis of 29 cases].
Zhonghua Zhong Liu Za Zhi. 2012 May; 34(5):390-3.ZZ

Abstract

OBJECTIVE

To study the clinical manifestations and radiological characteristics, diagnostic methods and outcomes of pulmonary mucosa-associated lymphoid tissue-derived(MALT) lymphoma.

METHODS

A retrospective review of clinical, radiological and follow-up data of 29 pulmonary MALT lymphoma cases at Shanghai Pulmonary Hospital affiliated to Tong Ji University from January 2002 to June 2010 was performed.

RESULTS

Among these patients, there were 19(65.5%) males and 10 (34.5%) females aged from 27 to 73 (median 53) years old. Common clinical manifestations were cough (51.7%), fever (20.7%), apnea (17.2%), chest pain (17.2%), fatigue (13.8%) and weight loss (13.8%), while 9(31.0%) cases had no symptoms at diagnosis. The characteristics of the chest CT showed that 22 (75.9%) of the cases had patch infiltration or consolidation of the lung, 7(24.1%) of the cases had mass, and 15 (51.7%) unilateral and 14(48.3%) bilateral lesions. Their diagnosis duration varied between 0.5 and 96 months. 18(62.1%) cases were confirmed by surgery (15 open lung and 7 video-assisted thoracic surgery, VAST), 4 (13.8%) by percutaneous lung biopsy, 5 (17.2%) by bronchoscopic biopsy, and 2 (6.9%) by peripheral lymph node biopsy. The treatment methods included surgery, combined chemotherapy, radiotherapy and Chinese herbal medicine. The 1- and 3-year-survival rates were 92.3% and 87.4%, respectively.

CONCLUSIONS

Pulmonary MALT lymphoma is atypical in clinical manifestations and radiological characteristics, and easy to be misdiagnosed. Local diseases are mainly treated by operation while extensive diseases receive combined chemotherapy. A proper diagnosis is mainly based on pathological biopsy. Patients with MALT lymphoma have a favorable outcome. Poor prognosis may be connected with poor performance status and long diagnosis duration.

Authors+Show Affiliations

Department of Oncology, Tongji University School of Medicine, Shanghai, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

chi

PubMed ID

22883464

Citation

Li, Ai-wu, et al. "[Clinical Characteristics and Diagnosis of Pulmonary Mucosa-associated Lymphoid Tissue-derived (MALT) Lymphoma: a Retrospective Analysis of 29 Cases]." Zhonghua Zhong Liu Za Zhi [Chinese Journal of Oncology], vol. 34, no. 5, 2012, pp. 390-3.
Li AW, Xu JF, Zhou CC, et al. [Clinical characteristics and diagnosis of pulmonary mucosa-associated lymphoid tissue-derived (MALT) lymphoma: a retrospective analysis of 29 cases]. Zhonghua Zhong Liu Za Zhi. 2012;34(5):390-3.
Li, A. W., Xu, J. F., Zhou, C. C., Wu, C. Y., & Wang, Y. L. (2012). [Clinical characteristics and diagnosis of pulmonary mucosa-associated lymphoid tissue-derived (MALT) lymphoma: a retrospective analysis of 29 cases]. Zhonghua Zhong Liu Za Zhi [Chinese Journal of Oncology], 34(5), 390-3. https://doi.org/10. 3760/cma.j.issn.0253-3766.2012.05.017
Li AW, et al. [Clinical Characteristics and Diagnosis of Pulmonary Mucosa-associated Lymphoid Tissue-derived (MALT) Lymphoma: a Retrospective Analysis of 29 Cases]. Zhonghua Zhong Liu Za Zhi. 2012;34(5):390-3. PubMed PMID: 22883464.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Clinical characteristics and diagnosis of pulmonary mucosa-associated lymphoid tissue-derived (MALT) lymphoma: a retrospective analysis of 29 cases]. AU - Li,Ai-wu, AU - Xu,Jian-fang, AU - Zhou,Cai-cun, AU - Wu,Chun-yan, AU - Wang,Yan-li, PY - 2012/8/14/entrez PY - 2012/8/14/pubmed PY - 2013/3/15/medline SP - 390 EP - 3 JF - Zhonghua zhong liu za zhi [Chinese journal of oncology] JO - Zhonghua Zhong Liu Za Zhi VL - 34 IS - 5 N2 - OBJECTIVE: To study the clinical manifestations and radiological characteristics, diagnostic methods and outcomes of pulmonary mucosa-associated lymphoid tissue-derived(MALT) lymphoma. METHODS: A retrospective review of clinical, radiological and follow-up data of 29 pulmonary MALT lymphoma cases at Shanghai Pulmonary Hospital affiliated to Tong Ji University from January 2002 to June 2010 was performed. RESULTS: Among these patients, there were 19(65.5%) males and 10 (34.5%) females aged from 27 to 73 (median 53) years old. Common clinical manifestations were cough (51.7%), fever (20.7%), apnea (17.2%), chest pain (17.2%), fatigue (13.8%) and weight loss (13.8%), while 9(31.0%) cases had no symptoms at diagnosis. The characteristics of the chest CT showed that 22 (75.9%) of the cases had patch infiltration or consolidation of the lung, 7(24.1%) of the cases had mass, and 15 (51.7%) unilateral and 14(48.3%) bilateral lesions. Their diagnosis duration varied between 0.5 and 96 months. 18(62.1%) cases were confirmed by surgery (15 open lung and 7 video-assisted thoracic surgery, VAST), 4 (13.8%) by percutaneous lung biopsy, 5 (17.2%) by bronchoscopic biopsy, and 2 (6.9%) by peripheral lymph node biopsy. The treatment methods included surgery, combined chemotherapy, radiotherapy and Chinese herbal medicine. The 1- and 3-year-survival rates were 92.3% and 87.4%, respectively. CONCLUSIONS: Pulmonary MALT lymphoma is atypical in clinical manifestations and radiological characteristics, and easy to be misdiagnosed. Local diseases are mainly treated by operation while extensive diseases receive combined chemotherapy. A proper diagnosis is mainly based on pathological biopsy. Patients with MALT lymphoma have a favorable outcome. Poor prognosis may be connected with poor performance status and long diagnosis duration. SN - 0253-3766 UR - https://www.unboundmedicine.com/medline/citation/22883464/[Clinical_characteristics_and_diagnosis_of_pulmonary_mucosa_associated_lymphoid_tissue_derived__MALT__lymphoma:_a_retrospective_analysis_of_29_cases]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&issn=0253-3766&year=2012&vol=34&issue=5&fpage=390 DB - PRIME DP - Unbound Medicine ER -