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[Study on the relationship between altered expression of annexin A4 and endometrial receptivity during the implantation window in infertile patients with endometriosis].
Zhonghua Fu Chan Ke Za Zhi 2012; 47(5):324-7ZF

Abstract

OBJECTIVE

To identify the differential expressed proteins, and to investigate the relationship between altered expression of annexin A4 during window of implantation [WOI (at day-6 after ovulatory day)] in infertile patients with endometriosis and endometrial receptivity.

METHODS

Two-dimensional fluorescence differential in-gel electrophoresis (2D-DIGE) and matrix-assist laser desorption ionization-time of flight-mass spectrometry (MALDI-TOF-MS) were used to detect protein expression in endometrial WOI in 10 infertile cases with endometriosis as endometriosis group and 10 infertile cases with tubal factors as control group. The semi-quantitative validation of annexin A4 in the eutopic endometrial tissue during WOI was analyzed by western blot.

RESULTS

By comparing protein profiles, there were 7 meaningful differential proteins during WOI in infertile patients with endometriosis. One protein with an isoelectric point of 5.84 and relative molecular weight of 36 100 were down regulated 348% in samples of endometriosis group. It was identified as annexin A4 by mass spectrometry. By western blot, relative intensity of annexin A4 in endometriosis group was 7.2 ± 0.9, which was lower than 17.8 ± 2.6 in control group significantly (t = 7.654, P = 0.002).

CONCLUSION

Lower expression of annexin A4 during WOI in infertile patients with endometriosis might be associated with the decrease of endometrial receptivity.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Third Affiliated Hospital of Guangzhou Medical College, Guangzhou 510150, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

22883517

Citation

Jiang, Ya-ling, et al. "[Study On the Relationship Between Altered Expression of Annexin A4 and Endometrial Receptivity During the Implantation Window in Infertile Patients With Endometriosis]." Zhonghua Fu Chan Ke Za Zhi, vol. 47, no. 5, 2012, pp. 324-7.
Jiang YL, Li B, Xing FQ, et al. [Study on the relationship between altered expression of annexin A4 and endometrial receptivity during the implantation window in infertile patients with endometriosis]. Zhonghua Fu Chan Ke Za Zhi. 2012;47(5):324-7.
Jiang, Y. L., Li, B., Xing, F. Q., Wang, F., & Feng, J. H. (2012). [Study on the relationship between altered expression of annexin A4 and endometrial receptivity during the implantation window in infertile patients with endometriosis]. Zhonghua Fu Chan Ke Za Zhi, 47(5), pp. 324-7.
Jiang YL, et al. [Study On the Relationship Between Altered Expression of Annexin A4 and Endometrial Receptivity During the Implantation Window in Infertile Patients With Endometriosis]. Zhonghua Fu Chan Ke Za Zhi. 2012;47(5):324-7. PubMed PMID: 22883517.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Study on the relationship between altered expression of annexin A4 and endometrial receptivity during the implantation window in infertile patients with endometriosis]. AU - Jiang,Ya-ling, AU - Li,Bing, AU - Xing,Fu-qi, AU - Wang,Fang, AU - Feng,Jian-huai, PY - 2012/8/14/entrez PY - 2012/8/14/pubmed PY - 2013/2/16/medline SP - 324 EP - 7 JF - Zhonghua fu chan ke za zhi JO - Zhonghua Fu Chan Ke Za Zhi VL - 47 IS - 5 N2 - OBJECTIVE: To identify the differential expressed proteins, and to investigate the relationship between altered expression of annexin A4 during window of implantation [WOI (at day-6 after ovulatory day)] in infertile patients with endometriosis and endometrial receptivity. METHODS: Two-dimensional fluorescence differential in-gel electrophoresis (2D-DIGE) and matrix-assist laser desorption ionization-time of flight-mass spectrometry (MALDI-TOF-MS) were used to detect protein expression in endometrial WOI in 10 infertile cases with endometriosis as endometriosis group and 10 infertile cases with tubal factors as control group. The semi-quantitative validation of annexin A4 in the eutopic endometrial tissue during WOI was analyzed by western blot. RESULTS: By comparing protein profiles, there were 7 meaningful differential proteins during WOI in infertile patients with endometriosis. One protein with an isoelectric point of 5.84 and relative molecular weight of 36 100 were down regulated 348% in samples of endometriosis group. It was identified as annexin A4 by mass spectrometry. By western blot, relative intensity of annexin A4 in endometriosis group was 7.2 ± 0.9, which was lower than 17.8 ± 2.6 in control group significantly (t = 7.654, P = 0.002). CONCLUSION: Lower expression of annexin A4 during WOI in infertile patients with endometriosis might be associated with the decrease of endometrial receptivity. SN - 0529-567X UR - https://www.unboundmedicine.com/medline/citation/22883517/[Study_on_the_relationship_between_altered_expression_of_annexin_A4_and_endometrial_receptivity_during_the_implantation_window_in_infertile_patients_with_endometriosis]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&issn=0529-567X&year=2012&vol=47&issue=5&fpage=324 DB - PRIME DP - Unbound Medicine ER -