TY - JOUR T1 - Determination of artificial sweeteners in water samples by solid-phase extraction and liquid chromatography-tandem mass spectrometry. AU - Ordóñez,Edgar Y, AU - Quintana,José Benito, AU - Rodil,Rosario, AU - Cela,Rafael, Y1 - 2012/07/31/ PY - 2012/06/14/received PY - 2012/07/20/revised PY - 2012/07/20/accepted PY - 2012/8/14/entrez PY - 2012/8/14/pubmed PY - 2012/12/10/medline SP - 197 EP - 205 JF - Journal of chromatography. A JO - J Chromatogr A VL - 1256 N2 - The development and performance evaluation of an analytical method for the determination of six artificial sweeteners in environmental waters using solid-phase extraction (SPE) followed by liquid chromatography-tandem mass spectrometry are presented. To this end, different SPE alternatives have been evaluated: polymeric reversed-phase (Oasis HLB, Env+, Plexa and Strata X), and mixed-mode with either weak (Oasis WAX) or strong anionic-exchange (Oasis MAX and Plexa PAX) sorbents. Among them, reversed-phase sorbents, particularly Oasis HLB and Strata X, showed the best performance. Oasis HLB provided good trueness (recoveries: 73-112%), precision (RSD<10%) and limits of quantification (LOQ: 0.01-0.5 μg/L). Moreover, two LC separation mechanisms were evaluated: reversed-phase (RPLC) and hydrophilic interaction (HILIC), with RPLC providing better performance than HILIC. The final application of the method showed the presence of acesulfame, cyclamate, saccharin and sucralose in the wastewater and surface water samples analyzed at concentrations up to 54 μg/L. SN - 1873-3778 UR - https://www.unboundmedicine.com/medline/citation/22885054/Determination_of_artificial_sweeteners_in_water_samples_by_solid_phase_extraction_and_liquid_chromatography_tandem_mass_spectrometry_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0021-9673(12)01144-2 DB - PRIME DP - Unbound Medicine ER -