Tags

Type your tag names separated by a space and hit enter

Contribution of 4-1BBL on radioresistant cells in providing survival signals through 4-1BB expressed on CD8⁺ memory T cells in the bone marrow.
Eur J Immunol. 2012 Nov; 42(11):2861-74.EJ

Abstract

The persistence of memory lymphocytes is a critical feature of adaptive immunity. The TNF family ligand 4-1BBL supports the antigen-independent survival of CD8⁺ memory T cells. Here, we show that mice lacking 4-1BB only on αβ T cells show a similar defect in CD8⁺ T-cell recall responses, as previously shown in 4-1BBL-deficient mice. We show that 4-1BB is selectively expressed on BM CD8⁺ but not CD4⁺ memory T cells of unimmunized mice. Its ligand, 4-1BBL, is found on VCAM-1⁺ stromal cells, CD11c⁺ cells, and a Gr1(lo) myeloid population in unimmunized mice. Adoptive transfer of in vitro generated memory T cells into mice lacking 4-1BBL only on radioresistant cells recapitulates the defect in CD8⁺ T-cell survival seen in the complete knockout mice, with smaller effects of 4-1BBL on hematopoietic cells. In BM, adoptively transferred DsRed CD8⁺ memory T cells are most often found in proximity to VCAM-1⁺ cells or Gr1⁺ cells, followed by B220⁺ cells and to a much lesser extent near CD11c⁺ cells. Thus, a VCAM-1⁺CD45(-) stromal cell is a plausible candidate for the radioresistant cell that provides 4-1BBL to CD8⁺ memory T cells in the BM.

Authors+Show Affiliations

Department of Immunology, University of Toronto, Toronto, ON, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22886791

Citation

Lin, Gloria H Y., et al. "Contribution of 4-1BBL On Radioresistant Cells in Providing Survival Signals Through 4-1BB Expressed On CD8⁺ Memory T Cells in the Bone Marrow." European Journal of Immunology, vol. 42, no. 11, 2012, pp. 2861-74.
Lin GH, Edele F, Mbanwi AN, et al. Contribution of 4-1BBL on radioresistant cells in providing survival signals through 4-1BB expressed on CD8⁺ memory T cells in the bone marrow. Eur J Immunol. 2012;42(11):2861-74.
Lin, G. H., Edele, F., Mbanwi, A. N., Wortzman, M. E., Snell, L. M., Vidric, M., Roth, K., Hauser, A. E., & Watts, T. H. (2012). Contribution of 4-1BBL on radioresistant cells in providing survival signals through 4-1BB expressed on CD8⁺ memory T cells in the bone marrow. European Journal of Immunology, 42(11), 2861-74. https://doi.org/10.1002/eji.201242503
Lin GH, et al. Contribution of 4-1BBL On Radioresistant Cells in Providing Survival Signals Through 4-1BB Expressed On CD8⁺ Memory T Cells in the Bone Marrow. Eur J Immunol. 2012;42(11):2861-74. PubMed PMID: 22886791.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Contribution of 4-1BBL on radioresistant cells in providing survival signals through 4-1BB expressed on CD8⁺ memory T cells in the bone marrow. AU - Lin,Gloria H Y, AU - Edele,Fanny, AU - Mbanwi,Achire N, AU - Wortzman,Michael E, AU - Snell,Laura M, AU - Vidric,Mariana, AU - Roth,Katrin, AU - Hauser,Anja E, AU - Watts,Tania H, Y1 - 2012/09/20/ PY - 2012/02/29/received PY - 2012/06/29/revised PY - 2012/08/01/accepted PY - 2012/8/14/entrez PY - 2012/8/14/pubmed PY - 2013/3/30/medline SP - 2861 EP - 74 JF - European journal of immunology JO - Eur. J. Immunol. VL - 42 IS - 11 N2 - The persistence of memory lymphocytes is a critical feature of adaptive immunity. The TNF family ligand 4-1BBL supports the antigen-independent survival of CD8⁺ memory T cells. Here, we show that mice lacking 4-1BB only on αβ T cells show a similar defect in CD8⁺ T-cell recall responses, as previously shown in 4-1BBL-deficient mice. We show that 4-1BB is selectively expressed on BM CD8⁺ but not CD4⁺ memory T cells of unimmunized mice. Its ligand, 4-1BBL, is found on VCAM-1⁺ stromal cells, CD11c⁺ cells, and a Gr1(lo) myeloid population in unimmunized mice. Adoptive transfer of in vitro generated memory T cells into mice lacking 4-1BBL only on radioresistant cells recapitulates the defect in CD8⁺ T-cell survival seen in the complete knockout mice, with smaller effects of 4-1BBL on hematopoietic cells. In BM, adoptively transferred DsRed CD8⁺ memory T cells are most often found in proximity to VCAM-1⁺ cells or Gr1⁺ cells, followed by B220⁺ cells and to a much lesser extent near CD11c⁺ cells. Thus, a VCAM-1⁺CD45(-) stromal cell is a plausible candidate for the radioresistant cell that provides 4-1BBL to CD8⁺ memory T cells in the BM. SN - 1521-4141 UR - https://www.unboundmedicine.com/medline/citation/22886791/Contribution_of_4_1BBL_on_radioresistant_cells_in_providing_survival_signals_through_4_1BB_expressed_on_CD8⁺_memory_T_cells_in_the_bone_marrow_ L2 - https://doi.org/10.1002/eji.201242503 DB - PRIME DP - Unbound Medicine ER -