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Alternate day fasting (ADF) with a high-fat diet produces similar weight loss and cardio-protection as ADF with a low-fat diet.
Metabolism. 2013 Jan; 62(1):137-43.M

Abstract

Alternate day fasting (ADF) with a low-fat (LF) diet is effective for weight loss and cardio-protection. However, the applicability of these findings is questionable as the majority of Americans consume a high-fat (HF) diet.

OBJECTIVE

The goal of this study was to determine if these beneficial changes in body weight and coronary heart disease (CHD) risk can be reproduced if an HF background diet is used in place of an LF diet during ADF.

METHODS

Thirty-two obese subjects were randomized to an ADF-HF (45% fat) or ADF-LF diet (25% fat), which consisted of two phases: 1) a 2-week baseline weight maintenance period, and 2) an 8-week ADF weight loss period. All food was provided during the study.

RESULTS

Body weight was reduced (P<0.0001) by ADF-HF (4.8%±1.1%) and by ADF-LF (4.2%±0.8%). Fat mass decreased (P<0.0001) by ADF-HF (5.4±1.5 kg) and ADF-LF (4.2±0.6 kg). Fat free mass remained unchanged. Waist circumference decreased (P<0.001) by ADF-HF (7.2±1.5 cm) and ADF-LF (7.3±0.9 cm). LDL cholesterol and triacylglycerol concentrations were reduced (P<0.001) by both interventions (ADF-HF: 18.3%±4.6%, 13.7%±4.8%; and ADF-LF: 24.8%±2.6%, 14.3%±4.4%). HDL cholesterol, blood pressure, and heart rate remained unchanged. There were no between-group differences for any parameter.

CONCLUSION

These findings suggest that an ADF-HF diet is equally as effective as an ADF-LF diet in helping obese subjects lose weight and improve CHD risk factors.

Authors+Show Affiliations

Department of Kinesiology and Nutrition, University of Illinois at Chicago, 1919 West Taylor Street, Room 506F, Chicago, IL 60612, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22889512

Citation

Klempel, Monica C., et al. "Alternate Day Fasting (ADF) With a High-fat Diet Produces Similar Weight Loss and Cardio-protection as ADF With a Low-fat Diet." Metabolism: Clinical and Experimental, vol. 62, no. 1, 2013, pp. 137-43.
Klempel MC, Kroeger CM, Varady KA. Alternate day fasting (ADF) with a high-fat diet produces similar weight loss and cardio-protection as ADF with a low-fat diet. Metabolism. 2013;62(1):137-43.
Klempel, M. C., Kroeger, C. M., & Varady, K. A. (2013). Alternate day fasting (ADF) with a high-fat diet produces similar weight loss and cardio-protection as ADF with a low-fat diet. Metabolism: Clinical and Experimental, 62(1), 137-43. https://doi.org/10.1016/j.metabol.2012.07.002
Klempel MC, Kroeger CM, Varady KA. Alternate Day Fasting (ADF) With a High-fat Diet Produces Similar Weight Loss and Cardio-protection as ADF With a Low-fat Diet. Metabolism. 2013;62(1):137-43. PubMed PMID: 22889512.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alternate day fasting (ADF) with a high-fat diet produces similar weight loss and cardio-protection as ADF with a low-fat diet. AU - Klempel,Monica C, AU - Kroeger,Cynthia M, AU - Varady,Krista A, Y1 - 2012/08/11/ PY - 2012/05/16/received PY - 2012/07/06/revised PY - 2012/07/09/accepted PY - 2012/8/15/entrez PY - 2012/8/15/pubmed PY - 2013/5/4/medline SP - 137 EP - 43 JF - Metabolism: clinical and experimental JO - Metabolism VL - 62 IS - 1 N2 - UNLABELLED: Alternate day fasting (ADF) with a low-fat (LF) diet is effective for weight loss and cardio-protection. However, the applicability of these findings is questionable as the majority of Americans consume a high-fat (HF) diet. OBJECTIVE: The goal of this study was to determine if these beneficial changes in body weight and coronary heart disease (CHD) risk can be reproduced if an HF background diet is used in place of an LF diet during ADF. METHODS: Thirty-two obese subjects were randomized to an ADF-HF (45% fat) or ADF-LF diet (25% fat), which consisted of two phases: 1) a 2-week baseline weight maintenance period, and 2) an 8-week ADF weight loss period. All food was provided during the study. RESULTS: Body weight was reduced (P<0.0001) by ADF-HF (4.8%±1.1%) and by ADF-LF (4.2%±0.8%). Fat mass decreased (P<0.0001) by ADF-HF (5.4±1.5 kg) and ADF-LF (4.2±0.6 kg). Fat free mass remained unchanged. Waist circumference decreased (P<0.001) by ADF-HF (7.2±1.5 cm) and ADF-LF (7.3±0.9 cm). LDL cholesterol and triacylglycerol concentrations were reduced (P<0.001) by both interventions (ADF-HF: 18.3%±4.6%, 13.7%±4.8%; and ADF-LF: 24.8%±2.6%, 14.3%±4.4%). HDL cholesterol, blood pressure, and heart rate remained unchanged. There were no between-group differences for any parameter. CONCLUSION: These findings suggest that an ADF-HF diet is equally as effective as an ADF-LF diet in helping obese subjects lose weight and improve CHD risk factors. SN - 1532-8600 UR - https://www.unboundmedicine.com/medline/citation/22889512/Alternate_day_fasting__ADF__with_a_high_fat_diet_produces_similar_weight_loss_and_cardio_protection_as_ADF_with_a_low_fat_diet_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0026-0495(12)00256-9 DB - PRIME DP - Unbound Medicine ER -