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Discriminative hypomania checklist-32 factors in unipolar and bipolar major depressive patients.
Psychopathology. 2012; 45(6):390-8.P

Abstract

BACKGROUND

Although manic or hypomanic episodes define bipolar disorder (BD), most patients show a predominance of depressive symptomatology, often associated with delayed or disregarded BD diagnosis. The Hypomania Checklist-32 (HCL-32) has therefore been developed and tested internationally to facilitate BD recognition.

SAMPLING AND METHODS

Five hundred seventy-one (563 eligible) patients diagnosed with a major depressive episode according to DSM-IV criteria were consecutively enrolled in a cross-sectional, multicenter, observational study (Come To Me). Lifetime manic or hypomanic features were assessed by the HCL-32, and severity of depressive and anxious symptomatology was assessed using the Zung's self-report questionnaires for depression and anxiety.

RESULTS

Among the patients diagnosed with BD (n = 119), either type I or type II, the occurrence of (hypo)manic symptoms was significantly higher compared to major depressive disorder (MDD) symptoms according to HCL-32 total and subscale scores obtained using a score of 14, which ensured an optimal discrimination between BD and MDD with a sensitivity of 0.85 and a specificity of 0.78.

CONCLUSIONS

Although some false positives might occur, the HCL-32 was confirmed to be a useful instrument in the detection of past hypomania in MDD patients, finally contributing to proper therapeutic choices.

Authors+Show Affiliations

Department of Psychiatry, University of Pisa, Pisa, Italy. giulio.perugi@med.unipi.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22890230

Citation

Perugi, Giulio, et al. "Discriminative Hypomania Checklist-32 Factors in Unipolar and Bipolar Major Depressive Patients." Psychopathology, vol. 45, no. 6, 2012, pp. 390-8.
Perugi G, Fornaro M, Maremmani I, et al. Discriminative hypomania checklist-32 factors in unipolar and bipolar major depressive patients. Psychopathology. 2012;45(6):390-8.
Perugi, G., Fornaro, M., Maremmani, I., Canonico, P. L., Carbonatto, P., Mencacci, C., Muscettola, G., Pani, L., Torta, R., Vampini, C., Parazzini, F., Dumitriu, A., & Angst, J. (2012). Discriminative hypomania checklist-32 factors in unipolar and bipolar major depressive patients. Psychopathology, 45(6), 390-8. https://doi.org/10.1159/000338047
Perugi G, et al. Discriminative Hypomania Checklist-32 Factors in Unipolar and Bipolar Major Depressive Patients. Psychopathology. 2012;45(6):390-8. PubMed PMID: 22890230.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Discriminative hypomania checklist-32 factors in unipolar and bipolar major depressive patients. AU - Perugi,Giulio, AU - Fornaro,Michele, AU - Maremmani,Icro, AU - Canonico,Pier Luigi, AU - Carbonatto,Paolo, AU - Mencacci,Claudio, AU - Muscettola,Giovanni, AU - Pani,Luca, AU - Torta,Riccardo, AU - Vampini,Claudio, AU - Parazzini,Fabio, AU - Dumitriu,Arina, AU - Angst,Jules, AU - ,, Y1 - 2012/08/07/ PY - 2011/04/15/received PY - 2012/03/13/accepted PY - 2012/8/15/entrez PY - 2012/8/15/pubmed PY - 2013/3/22/medline SP - 390 EP - 8 JF - Psychopathology JO - Psychopathology VL - 45 IS - 6 N2 - BACKGROUND: Although manic or hypomanic episodes define bipolar disorder (BD), most patients show a predominance of depressive symptomatology, often associated with delayed or disregarded BD diagnosis. The Hypomania Checklist-32 (HCL-32) has therefore been developed and tested internationally to facilitate BD recognition. SAMPLING AND METHODS: Five hundred seventy-one (563 eligible) patients diagnosed with a major depressive episode according to DSM-IV criteria were consecutively enrolled in a cross-sectional, multicenter, observational study (Come To Me). Lifetime manic or hypomanic features were assessed by the HCL-32, and severity of depressive and anxious symptomatology was assessed using the Zung's self-report questionnaires for depression and anxiety. RESULTS: Among the patients diagnosed with BD (n = 119), either type I or type II, the occurrence of (hypo)manic symptoms was significantly higher compared to major depressive disorder (MDD) symptoms according to HCL-32 total and subscale scores obtained using a score of 14, which ensured an optimal discrimination between BD and MDD with a sensitivity of 0.85 and a specificity of 0.78. CONCLUSIONS: Although some false positives might occur, the HCL-32 was confirmed to be a useful instrument in the detection of past hypomania in MDD patients, finally contributing to proper therapeutic choices. SN - 1423-033X UR - https://www.unboundmedicine.com/medline/citation/22890230/Discriminative_hypomania_checklist_32_factors_in_unipolar_and_bipolar_major_depressive_patients_ L2 - https://www.karger.com?DOI=10.1159/000338047 DB - PRIME DP - Unbound Medicine ER -