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Hidden evolutionary complexity of Nucleo-Cytoplasmic Large DNA viruses of eukaryotes.
Virol J. 2012 Aug 14; 9:161.VJ

Abstract

BACKGROUND

The Nucleo-Cytoplasmic Large DNA Viruses (NCLDV) constitute an apparently monophyletic group that consists of at least 6 families of viruses infecting a broad variety of eukaryotic hosts. A comprehensive genome comparison and maximum-likelihood reconstruction of the NCLDV evolution revealed a set of approximately 50 conserved, core genes that could be mapped to the genome of the common ancestor of this class of eukaryotic viruses.

RESULTS

We performed a detailed phylogenetic analysis of these core NCLDV genes and applied the constrained tree approach to show that the majority of the core genes are unlikely to be monophyletic. Several of the core genes have been independently acquired from different sources by different NCLDV lineages whereas for the majority of these genes displacement by homologs from cellular organisms in one or more groups of the NCLDV was demonstrated.

CONCLUSIONS

A detailed study of the evolution of the genomic core of the NCLDV reveals substantial complexity and diversity of evolutionary scenarios that was largely unsuspected previously. The phylogenetic coherence between the core genes is sufficient to validate the hypothesis on the evolution of all NCLDV from a common ancestral virus although the set of ancestral genes might be smaller than previously inferred from patterns of gene presence-absence.

Authors+Show Affiliations

National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Intramural

Language

eng

PubMed ID

22891861

Citation

Yutin, Natalya, and Eugene V. Koonin. "Hidden Evolutionary Complexity of Nucleo-Cytoplasmic Large DNA Viruses of Eukaryotes." Virology Journal, vol. 9, 2012, p. 161.
Yutin N, Koonin EV. Hidden evolutionary complexity of Nucleo-Cytoplasmic Large DNA viruses of eukaryotes. Virol J. 2012;9:161.
Yutin, N., & Koonin, E. V. (2012). Hidden evolutionary complexity of Nucleo-Cytoplasmic Large DNA viruses of eukaryotes. Virology Journal, 9, 161. https://doi.org/10.1186/1743-422X-9-161
Yutin N, Koonin EV. Hidden Evolutionary Complexity of Nucleo-Cytoplasmic Large DNA Viruses of Eukaryotes. Virol J. 2012 Aug 14;9:161. PubMed PMID: 22891861.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hidden evolutionary complexity of Nucleo-Cytoplasmic Large DNA viruses of eukaryotes. AU - Yutin,Natalya, AU - Koonin,Eugene V, Y1 - 2012/08/14/ PY - 2012/02/10/received PY - 2012/08/08/accepted PY - 2012/8/16/entrez PY - 2012/8/16/pubmed PY - 2013/4/16/medline SP - 161 EP - 161 JF - Virology journal JO - Virol J VL - 9 N2 - BACKGROUND: The Nucleo-Cytoplasmic Large DNA Viruses (NCLDV) constitute an apparently monophyletic group that consists of at least 6 families of viruses infecting a broad variety of eukaryotic hosts. A comprehensive genome comparison and maximum-likelihood reconstruction of the NCLDV evolution revealed a set of approximately 50 conserved, core genes that could be mapped to the genome of the common ancestor of this class of eukaryotic viruses. RESULTS: We performed a detailed phylogenetic analysis of these core NCLDV genes and applied the constrained tree approach to show that the majority of the core genes are unlikely to be monophyletic. Several of the core genes have been independently acquired from different sources by different NCLDV lineages whereas for the majority of these genes displacement by homologs from cellular organisms in one or more groups of the NCLDV was demonstrated. CONCLUSIONS: A detailed study of the evolution of the genomic core of the NCLDV reveals substantial complexity and diversity of evolutionary scenarios that was largely unsuspected previously. The phylogenetic coherence between the core genes is sufficient to validate the hypothesis on the evolution of all NCLDV from a common ancestral virus although the set of ancestral genes might be smaller than previously inferred from patterns of gene presence-absence. SN - 1743-422X UR - https://www.unboundmedicine.com/medline/citation/22891861/Hidden_evolutionary_complexity_of_Nucleo_Cytoplasmic_Large_DNA_viruses_of_eukaryotes_ L2 - https://virologyj.biomedcentral.com/articles/10.1186/1743-422X-9-161 DB - PRIME DP - Unbound Medicine ER -