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Age and risk for depression among the elderly: a meta-analysis of the published literature.
CNS Spectr 2012; 17(3):142-54CS

Abstract

OBJECTIVE

The goal of this study was to determine the relationship between age and risk for depression among the old and the oldest old. Method MEDLINE, EMBASE, and the Cochrane Library database were used to identify potential studies. The studies were divided into cross-sectional and longitudinal subsets. For each study, the numbers of the total participants, cases (for cross-sectional study), or incident cases (for longitudinal study) of depression in each age group were extracted and entered into Review Manager 4.2 software. Qualitative meta-analyses of cross-sectional studies and of longitudinal studies were performed. For prevalence and incidence rates of depression, odds risk (OR) and relative risk (RR) were calculated, respectively.

RESULTS

The qualitative meta-analyses showed that, compared with younger participants (above vs. below 65 years, above vs. below 70 years, above vs. below 75 years, and above vs. below 80 years), older age groups had a significantly higher risk for depression. (All of the ORs and RRs were significant.) Compared with participants aged 55-89, those aged above 90 years had no higher risk for depression. (Neither the OR nor the RR was significant.)

CONCLUSIONS

Despite the methodological limitations of this meta-analysis, older age appears to be an important risk factor for depression in the general elderly population (aged below 80 years), but not in the oldest population (aged above 85 years).

Authors+Show Affiliations

Department of Geriatrics, Chongqing Medical University, Chongqing, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22892113

Citation

Zhao, Ke-Xiang, et al. "Age and Risk for Depression Among the Elderly: a Meta-analysis of the Published Literature." CNS Spectrums, vol. 17, no. 3, 2012, pp. 142-54.
Zhao KX, Huang CQ, Xiao Q, et al. Age and risk for depression among the elderly: a meta-analysis of the published literature. CNS Spectr. 2012;17(3):142-54.
Zhao, K. X., Huang, C. Q., Xiao, Q., Gao, Y., Liu, Q. X., Wang, Z. R., ... Xie, Y. Z. (2012). Age and risk for depression among the elderly: a meta-analysis of the published literature. CNS Spectrums, 17(3), pp. 142-54. doi:10.1017/S1092852912000533.
Zhao KX, et al. Age and Risk for Depression Among the Elderly: a Meta-analysis of the Published Literature. CNS Spectr. 2012;17(3):142-54. PubMed PMID: 22892113.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Age and risk for depression among the elderly: a meta-analysis of the published literature. AU - Zhao,Ke-Xiang, AU - Huang,Chang-Quan, AU - Xiao,Qian, AU - Gao,Yuan, AU - Liu,Qing-Xiu, AU - Wang,Zheng-Rong, AU - Li,Yong-Hong, AU - Xie,Yi-Zhou, Y1 - 2012/08/15/ PY - 2012/8/16/entrez PY - 2012/8/16/pubmed PY - 2013/8/14/medline SP - 142 EP - 54 JF - CNS spectrums JO - CNS Spectr VL - 17 IS - 3 N2 - OBJECTIVE: The goal of this study was to determine the relationship between age and risk for depression among the old and the oldest old. Method MEDLINE, EMBASE, and the Cochrane Library database were used to identify potential studies. The studies were divided into cross-sectional and longitudinal subsets. For each study, the numbers of the total participants, cases (for cross-sectional study), or incident cases (for longitudinal study) of depression in each age group were extracted and entered into Review Manager 4.2 software. Qualitative meta-analyses of cross-sectional studies and of longitudinal studies were performed. For prevalence and incidence rates of depression, odds risk (OR) and relative risk (RR) were calculated, respectively. RESULTS: The qualitative meta-analyses showed that, compared with younger participants (above vs. below 65 years, above vs. below 70 years, above vs. below 75 years, and above vs. below 80 years), older age groups had a significantly higher risk for depression. (All of the ORs and RRs were significant.) Compared with participants aged 55-89, those aged above 90 years had no higher risk for depression. (Neither the OR nor the RR was significant.) CONCLUSIONS: Despite the methodological limitations of this meta-analysis, older age appears to be an important risk factor for depression in the general elderly population (aged below 80 years), but not in the oldest population (aged above 85 years). SN - 1092-8529 UR - https://www.unboundmedicine.com/medline/citation/22892113/Age_and_risk_for_depression_among_the_elderly:_a_meta_analysis_of_the_published_literature_ L2 - https://www.cambridge.org/core/product/identifier/S1092852912000533/type/journal_article DB - PRIME DP - Unbound Medicine ER -