Tags

Type your tag names separated by a space and hit enter

Antioxidant activity and hepatoprotective potential of Hammada scoparia against ethanol-induced liver injury in rats.
J Physiol Biochem 2013; 69(2):227-37JP

Abstract

The present work was aimed at studying the antioxidative activity and hepatoprotective effects of methanolic extract (ME) of Hammada scoparia leaves against ethanol-induced liver injury in male rats. The animals were treated daily with 35 % ethanol solution (4 g kg(-1) day(-1)) during 4 weeks. This treatment led to an increase in the lipid peroxidation, a decrease in antioxidative enzymes (catalase, superoxide dismutase, and glutathione peroxidase) in liver, and a considerable increase in the serum levels of aspartate and alanine aminotransferase and alkaline phospahatase. However, treatment with ME protects efficiently the hepatic function of alcoholic rats by the considerable decrease in aminotransferase contents in serum of ethanol-treated rats. The glycogen synthase kinase-3 β was inhibited after ME administration, which leads to an enhancement of glutathione peroxidase activity in the liver and a decrease in lipid peroxidation rate by 76 %. These biochemical changes were consistent with histopathological observations, suggesting marked hepatoprotective effect of ME. These results strongly suggest that treatment with methanolic extract normalizes various biochemical parameters and protects the liver against ethanol induced oxidative damage in rats.

Authors+Show Affiliations

Laboratoire d'Ecophysiologie Animale, Faculté des Sciences de Sfax, Sfax, Tunisia. b.ezzeddine@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22893526

Citation

Bourogaa, Ezzeddine, et al. "Antioxidant Activity and Hepatoprotective Potential of Hammada Scoparia Against Ethanol-induced Liver Injury in Rats." Journal of Physiology and Biochemistry, vol. 69, no. 2, 2013, pp. 227-37.
Bourogaa E, Nciri R, Mezghani-Jarraya R, et al. Antioxidant activity and hepatoprotective potential of Hammada scoparia against ethanol-induced liver injury in rats. J Physiol Biochem. 2013;69(2):227-37.
Bourogaa, E., Nciri, R., Mezghani-Jarraya, R., Racaud-Sultan, C., Damak, M., & El Feki, A. (2013). Antioxidant activity and hepatoprotective potential of Hammada scoparia against ethanol-induced liver injury in rats. Journal of Physiology and Biochemistry, 69(2), pp. 227-37. doi:10.1007/s13105-012-0206-7.
Bourogaa E, et al. Antioxidant Activity and Hepatoprotective Potential of Hammada Scoparia Against Ethanol-induced Liver Injury in Rats. J Physiol Biochem. 2013;69(2):227-37. PubMed PMID: 22893526.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidant activity and hepatoprotective potential of Hammada scoparia against ethanol-induced liver injury in rats. AU - Bourogaa,Ezzeddine, AU - Nciri,Riadh, AU - Mezghani-Jarraya,Raoudha, AU - Racaud-Sultan,Claire, AU - Damak,Mohamed, AU - El Feki,Abdelfattah, Y1 - 2012/08/15/ PY - 2012/04/20/received PY - 2012/08/02/accepted PY - 2012/8/16/entrez PY - 2012/8/16/pubmed PY - 2013/11/10/medline SP - 227 EP - 37 JF - Journal of physiology and biochemistry JO - J. Physiol. Biochem. VL - 69 IS - 2 N2 - The present work was aimed at studying the antioxidative activity and hepatoprotective effects of methanolic extract (ME) of Hammada scoparia leaves against ethanol-induced liver injury in male rats. The animals were treated daily with 35 % ethanol solution (4 g kg(-1) day(-1)) during 4 weeks. This treatment led to an increase in the lipid peroxidation, a decrease in antioxidative enzymes (catalase, superoxide dismutase, and glutathione peroxidase) in liver, and a considerable increase in the serum levels of aspartate and alanine aminotransferase and alkaline phospahatase. However, treatment with ME protects efficiently the hepatic function of alcoholic rats by the considerable decrease in aminotransferase contents in serum of ethanol-treated rats. The glycogen synthase kinase-3 β was inhibited after ME administration, which leads to an enhancement of glutathione peroxidase activity in the liver and a decrease in lipid peroxidation rate by 76 %. These biochemical changes were consistent with histopathological observations, suggesting marked hepatoprotective effect of ME. These results strongly suggest that treatment with methanolic extract normalizes various biochemical parameters and protects the liver against ethanol induced oxidative damage in rats. SN - 1877-8755 UR - https://www.unboundmedicine.com/medline/citation/22893526/Antioxidant_activity_and_hepatoprotective_potential_of_Hammada_scoparia_against_ethanol_induced_liver_injury_in_rats_ L2 - https://dx.doi.org/10.1007/s13105-012-0206-7 DB - PRIME DP - Unbound Medicine ER -