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Immediate and one-year outcome of patients presenting with acute coronary syndrome complicated by stroke: findings from the 2nd Gulf Registry of Acute Coronary Events (Gulf RACE-2).
BMC Cardiovasc Disord. 2012 Aug 16; 12:64.BC

Abstract

BACKGROUND

Stroke is a potential complication of acute coronary syndrome (ACS). The aim of this study was to identify the prevalence, risk factors predisposing to stroke, in-hospital and 1-year mortality among patients presenting with ACS in the Middle East.

METHODS

For a period of 9 months in 2008 to 2009, 7,930 consecutive ACS patients were enrolled from 65 hospitals in 6 Middle East countries.

RESULTS

The prevalence of in-hospital stroke following ACS was 0.70%. Most cases were ST segment elevation MI-related (STEMI) and ischemic stroke in nature. Patients with in-hospital stroke were 5 years older than patients without stroke and were more likely to have hypertension (66% vs. 47.6%, P = 0.001). There were no differences between the two groups in regards to gender, other cardiovascular risk factors, or prior cardiovascular disease. Patients with stroke were more likely to present with atypical symptoms, advanced Killip class and less likely to be treated with evidence-based therapies. Independent predictors of stroke were hypertension, advanced killip class, ACS type -STEMI and cardiogenic shock. Stroke was associated with increased risk of in-hospital (39.3% vs. 4.3%) and one-year mortality (52% vs. 12.3%).

CONCLUSION

There is low incidence of in-hospital stroke in Middle-Eastern patients presenting with ACS but with very high in-hospital and one-year mortality rates. Stroke patients were less likely to be appropriately treated with evidence-based therapy. Future work should be focused on reducing the risk and improving the outcome of this devastating complication.

Authors+Show Affiliations

Department of Cardiology, Hamad Medical Corporation (HMC), Doha, Qatar. jalsuwaidi@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22894647

Citation

Al Suwaidi, Jassim, et al. "Immediate and One-year Outcome of Patients Presenting With Acute Coronary Syndrome Complicated By Stroke: Findings From the 2nd Gulf Registry of Acute Coronary Events (Gulf RACE-2)." BMC Cardiovascular Disorders, vol. 12, 2012, p. 64.
Al Suwaidi J, Al Habib K, Asaad N, et al. Immediate and one-year outcome of patients presenting with acute coronary syndrome complicated by stroke: findings from the 2nd Gulf Registry of Acute Coronary Events (Gulf RACE-2). BMC Cardiovasc Disord. 2012;12:64.
Al Suwaidi, J., Al Habib, K., Asaad, N., Singh, R., Hersi, A., Al Falaeh, H., Al Saif, S., Al-Motarreb, A., Almahmeed, W., Sulaiman, K., Amin, H., Al-Lawati, J., Al-Sagheer, N. Q., Alsheikh-Ali, A. A., & Salam, A. M. (2012). Immediate and one-year outcome of patients presenting with acute coronary syndrome complicated by stroke: findings from the 2nd Gulf Registry of Acute Coronary Events (Gulf RACE-2). BMC Cardiovascular Disorders, 12, 64. https://doi.org/10.1186/1471-2261-12-64
Al Suwaidi J, et al. Immediate and One-year Outcome of Patients Presenting With Acute Coronary Syndrome Complicated By Stroke: Findings From the 2nd Gulf Registry of Acute Coronary Events (Gulf RACE-2). BMC Cardiovasc Disord. 2012 Aug 16;12:64. PubMed PMID: 22894647.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immediate and one-year outcome of patients presenting with acute coronary syndrome complicated by stroke: findings from the 2nd Gulf Registry of Acute Coronary Events (Gulf RACE-2). AU - Al Suwaidi,Jassim, AU - Al Habib,Khalid, AU - Asaad,Nidal, AU - Singh,Rajvir, AU - Hersi,Ahmad, AU - Al Falaeh,Husam, AU - Al Saif,Shukri, AU - Al-Motarreb,Ahmed, AU - Almahmeed,Wael, AU - Sulaiman,Kadhim, AU - Amin,Haitham, AU - Al-Lawati,Jawad, AU - Al-Sagheer,Norah Q, AU - Alsheikh-Ali,Alawi A, AU - Salam,Amar M, Y1 - 2012/08/16/ PY - 2011/12/11/received PY - 2012/08/09/accepted PY - 2012/8/17/entrez PY - 2012/8/17/pubmed PY - 2013/1/30/medline SP - 64 EP - 64 JF - BMC cardiovascular disorders JO - BMC Cardiovasc Disord VL - 12 N2 - BACKGROUND: Stroke is a potential complication of acute coronary syndrome (ACS). The aim of this study was to identify the prevalence, risk factors predisposing to stroke, in-hospital and 1-year mortality among patients presenting with ACS in the Middle East. METHODS: For a period of 9 months in 2008 to 2009, 7,930 consecutive ACS patients were enrolled from 65 hospitals in 6 Middle East countries. RESULTS: The prevalence of in-hospital stroke following ACS was 0.70%. Most cases were ST segment elevation MI-related (STEMI) and ischemic stroke in nature. Patients with in-hospital stroke were 5 years older than patients without stroke and were more likely to have hypertension (66% vs. 47.6%, P = 0.001). There were no differences between the two groups in regards to gender, other cardiovascular risk factors, or prior cardiovascular disease. Patients with stroke were more likely to present with atypical symptoms, advanced Killip class and less likely to be treated with evidence-based therapies. Independent predictors of stroke were hypertension, advanced killip class, ACS type -STEMI and cardiogenic shock. Stroke was associated with increased risk of in-hospital (39.3% vs. 4.3%) and one-year mortality (52% vs. 12.3%). CONCLUSION: There is low incidence of in-hospital stroke in Middle-Eastern patients presenting with ACS but with very high in-hospital and one-year mortality rates. Stroke patients were less likely to be appropriately treated with evidence-based therapy. Future work should be focused on reducing the risk and improving the outcome of this devastating complication. SN - 1471-2261 UR - https://www.unboundmedicine.com/medline/citation/22894647/Immediate_and_one_year_outcome_of_patients_presenting_with_acute_coronary_syndrome_complicated_by_stroke:_findings_from_the_2nd_Gulf_Registry_of_Acute_Coronary_Events__Gulf_RACE_2__ L2 - https://bmccardiovascdisord.biomedcentral.com/articles/10.1186/1471-2261-12-64 DB - PRIME DP - Unbound Medicine ER -