Tags

Type your tag names separated by a space and hit enter

The unexpected role of Drosophila OCRL during cytokinesis.
Commun Integr Biol 2012; 5(3):291-3CI

Abstract

Inositides are intrinsic components of cell membranes that regulate a wide variety of cellular functions. PtdIns(4,5)P(2,) one of the most abundant phosphoinositides, is restricted at the plasma membrane where it regulates numerous functions including cell division. We have recently established that the Drosophila inositol 5-phosphatase, dOCRL, is essential for cytokinesis, the last step of cell division (Ben El Kadhi et al. 2011).(8) We demonstrated that dOCRL is required for the dephosphorylation of PtdIns(4,5)P(2) at the surface of endosomes, resulting in the restriction of this phosphoinositide to the cell cortex during cytokinesis. dOCRL is the Drosophila ortholog of human OCRL1, a PtdIns(4,5)P(2) phosphatase mutated in the X-linked disorder oculocerebrorenal Lowe syndrome. Here, we discuss the relevance of our findings with reference to the role of human OCRL1 in non-pathological and pathological conditions.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22896796

Citation

Ben El Kadhi, Khaled, et al. "The Unexpected Role of Drosophila OCRL During Cytokinesis." Communicative & Integrative Biology, vol. 5, no. 3, 2012, pp. 291-3.
Ben El Kadhi K, Emery G, Carreno S. The unexpected role of Drosophila OCRL during cytokinesis. Commun Integr Biol. 2012;5(3):291-3.
Ben El Kadhi, K., Emery, G., & Carreno, S. (2012). The unexpected role of Drosophila OCRL during cytokinesis. Communicative & Integrative Biology, 5(3), pp. 291-3. doi:10.4161/cib.19914.
Ben El Kadhi K, Emery G, Carreno S. The Unexpected Role of Drosophila OCRL During Cytokinesis. Commun Integr Biol. 2012 May 1;5(3):291-3. PubMed PMID: 22896796.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The unexpected role of Drosophila OCRL during cytokinesis. AU - Ben El Kadhi,Khaled, AU - Emery,Grégory, AU - Carreno,Sebastien, PY - 2012/8/17/entrez PY - 2012/8/17/pubmed PY - 2012/8/17/medline KW - Lowe syndrome KW - OCRL1 KW - PtdIns(4,5)P2 KW - cell division KW - cytokinesis KW - intracellular trafficking KW - phosphoinositides SP - 291 EP - 3 JF - Communicative & integrative biology JO - Commun Integr Biol VL - 5 IS - 3 N2 - Inositides are intrinsic components of cell membranes that regulate a wide variety of cellular functions. PtdIns(4,5)P(2,) one of the most abundant phosphoinositides, is restricted at the plasma membrane where it regulates numerous functions including cell division. We have recently established that the Drosophila inositol 5-phosphatase, dOCRL, is essential for cytokinesis, the last step of cell division (Ben El Kadhi et al. 2011).(8) We demonstrated that dOCRL is required for the dephosphorylation of PtdIns(4,5)P(2) at the surface of endosomes, resulting in the restriction of this phosphoinositide to the cell cortex during cytokinesis. dOCRL is the Drosophila ortholog of human OCRL1, a PtdIns(4,5)P(2) phosphatase mutated in the X-linked disorder oculocerebrorenal Lowe syndrome. Here, we discuss the relevance of our findings with reference to the role of human OCRL1 in non-pathological and pathological conditions. SN - 1942-0889 UR - https://www.unboundmedicine.com/medline/citation/22896796/The_unexpected_role_of_Drosophila_OCRL_during_cytokinesis_ L2 - http://www.tandfonline.com/doi/full/10.4161/cib.19914 DB - PRIME DP - Unbound Medicine ER -