Tags

Type your tag names separated by a space and hit enter

Clinical correlates of erectile dysfunction and premature ejaculation in men with couple infertility.
J Sex Med. 2012 Oct; 9(10):2698-707.JS

Abstract

INTRODUCTION

The frequency and the clinical characteristics of erectile dysfunction (ED) and premature ejaculation (PE) in infertile men have been poorly investigated.

AIM

To assess the prevalence of ED and PE and their clinical correlates in men seeking medical care for couple infertility.

METHODS

A consecutive series of 244 men (mean age 35.2±7.8) with couple infertility was systematically evaluated. Erectile function was investigated with the International Index of Erectile Function-15 erectile function domain (IIEF-15-EFD) whereas ejaculatory status with the PE diagnostic tool (PEDT).

MAIN OUTCOME MEASURES

All patients underwent psychological (Middlesex Hospital Questionnaire [MHQ]), prostatitis symptoms (National Institutes of Health-chronic prostatitis symptom index [NIH-CPSI]); hormonal, seminal, and interleukin 8 (sIL-8; a surrogate marker of prostatitis) evaluation; along with scrotal and transrectal color Doppler ultrasound (CDU) assessment.

RESULTS

ED was found in 43 (17.8%) and PE in 38 (15.6%) subjects. After adjusting for age, IIEF-15-EFD score was negatively associated with depressive symptoms (MHQ-D score), somatization (MHQ-S score), NIH-CPSI total, and quality of life subdomain score. In a logistic multivariate model, among all these variables, only depression was significantly associated with ED (adjusted odds ratio [OR]=1.19 [1.02-1.39]; P<0.05). PEDT score was positively associated with prostatitis symptoms and signs, such as sIL-8 and prostate CDU abnormalities (including arterial prostatic peak systolic velocity, APPSV), phobic anxiety (MHQ-P score), and calculated free testosterone (cFT). The association between PE and NIH-CPSI score or APPSV was confirmed even after adjustment for age, MHQ-P score and cFT (adjusted OR=1.11 [1.05-1.17]; P<0.0001 and 1.22 [1.03-1.44]; P=0.02, for NIH-CPSI score and APPSV, respectively).

CONCLUSIONS

ED and PE are reported by one in six infertile patients. ED is mainly associated with depressive symptoms, while PEDT score is positively associated with prostatitis symptoms and signs, phobic anxiety, and cFT.

Authors+Show Affiliations

Sexual Medicine and Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22897716

Citation

Lotti, Francesco, et al. "Clinical Correlates of Erectile Dysfunction and Premature Ejaculation in Men With Couple Infertility." The Journal of Sexual Medicine, vol. 9, no. 10, 2012, pp. 2698-707.
Lotti F, Corona G, Rastrelli G, et al. Clinical correlates of erectile dysfunction and premature ejaculation in men with couple infertility. J Sex Med. 2012;9(10):2698-707.
Lotti, F., Corona, G., Rastrelli, G., Forti, G., Jannini, E. A., & Maggi, M. (2012). Clinical correlates of erectile dysfunction and premature ejaculation in men with couple infertility. The Journal of Sexual Medicine, 9(10), 2698-707. https://doi.org/10.1111/j.1743-6109.2012.02872.x
Lotti F, et al. Clinical Correlates of Erectile Dysfunction and Premature Ejaculation in Men With Couple Infertility. J Sex Med. 2012;9(10):2698-707. PubMed PMID: 22897716.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical correlates of erectile dysfunction and premature ejaculation in men with couple infertility. AU - Lotti,Francesco, AU - Corona,Giovanni, AU - Rastrelli,Giulia, AU - Forti,Gianni, AU - Jannini,Emmanuele A, AU - Maggi,Mario, Y1 - 2012/08/15/ PY - 2012/8/18/entrez PY - 2012/8/18/pubmed PY - 2013/4/10/medline SP - 2698 EP - 707 JF - The journal of sexual medicine JO - J Sex Med VL - 9 IS - 10 N2 - INTRODUCTION: The frequency and the clinical characteristics of erectile dysfunction (ED) and premature ejaculation (PE) in infertile men have been poorly investigated. AIM: To assess the prevalence of ED and PE and their clinical correlates in men seeking medical care for couple infertility. METHODS: A consecutive series of 244 men (mean age 35.2±7.8) with couple infertility was systematically evaluated. Erectile function was investigated with the International Index of Erectile Function-15 erectile function domain (IIEF-15-EFD) whereas ejaculatory status with the PE diagnostic tool (PEDT). MAIN OUTCOME MEASURES: All patients underwent psychological (Middlesex Hospital Questionnaire [MHQ]), prostatitis symptoms (National Institutes of Health-chronic prostatitis symptom index [NIH-CPSI]); hormonal, seminal, and interleukin 8 (sIL-8; a surrogate marker of prostatitis) evaluation; along with scrotal and transrectal color Doppler ultrasound (CDU) assessment. RESULTS: ED was found in 43 (17.8%) and PE in 38 (15.6%) subjects. After adjusting for age, IIEF-15-EFD score was negatively associated with depressive symptoms (MHQ-D score), somatization (MHQ-S score), NIH-CPSI total, and quality of life subdomain score. In a logistic multivariate model, among all these variables, only depression was significantly associated with ED (adjusted odds ratio [OR]=1.19 [1.02-1.39]; P<0.05). PEDT score was positively associated with prostatitis symptoms and signs, such as sIL-8 and prostate CDU abnormalities (including arterial prostatic peak systolic velocity, APPSV), phobic anxiety (MHQ-P score), and calculated free testosterone (cFT). The association between PE and NIH-CPSI score or APPSV was confirmed even after adjustment for age, MHQ-P score and cFT (adjusted OR=1.11 [1.05-1.17]; P<0.0001 and 1.22 [1.03-1.44]; P=0.02, for NIH-CPSI score and APPSV, respectively). CONCLUSIONS: ED and PE are reported by one in six infertile patients. ED is mainly associated with depressive symptoms, while PEDT score is positively associated with prostatitis symptoms and signs, phobic anxiety, and cFT. SN - 1743-6109 UR - https://www.unboundmedicine.com/medline/citation/22897716/Clinical_correlates_of_erectile_dysfunction_and_premature_ejaculation_in_men_with_couple_infertility_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1743-6095(15)33778-4 DB - PRIME DP - Unbound Medicine ER -