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Phytochemicals isolated from leaves of Chromolaena odorata: impact on viability and clonogenicity of cancer cell lines.
Phytother Res. 2013 Jun; 27(6):835-40.PR

Abstract

The leaves of Chromolaena odorata (Asteraceae) are exploited extensively in West and Central African ethnopharmacy for the treatment of a wide range of conditions, despite this being a non-native species established in the last 50 years. With the objective of seeking bioactive principles, the nonvolatile compounds, an ethanolic (80% v/v) extract was made and fractionated. From the hexane-soluble fraction, three compounds were isolated. Two of these, 5-hydroxy-7,4'-dimethoxyflavanone and 2'-hydroxy-4,4',5',6'-tetramethoxychalcone, have previously been identified in C. odorata leaves. The third was fully characterised spectroscopically and found to be 1,6-dimethyl-4-(1-methylethyl)naphthalene (cadalene), not previously isolated from the Asteraceae. All three compounds were tested for their cytotoxicity and anticancer properties. 2'-Hydroxy-4,4',5',6'-tetramethoxychalcone was found to be both cytotoxic and anticlonogenic at 20 µm in cell lines Cal51, MCF7 and MDAMB-468, and to act synergistically with the Bcl2 inhibitor ABT737 to enhance apoptosis in Cal51 breast cancer cells.

Authors+Show Affiliations

Elucidation of Biosynthesis by Isotopic Spectrometry Group, CEISAM, University of Nantes-CNRS UMR6230, Nantes, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22899281

Citation

Kouamé, Prevost Bi-Koffi, et al. "Phytochemicals Isolated From Leaves of Chromolaena Odorata: Impact On Viability and Clonogenicity of Cancer Cell Lines." Phytotherapy Research : PTR, vol. 27, no. 6, 2013, pp. 835-40.
Kouamé PB, Jacques C, Bedi G, et al. Phytochemicals isolated from leaves of Chromolaena odorata: impact on viability and clonogenicity of cancer cell lines. Phytother Res. 2013;27(6):835-40.
Kouamé, P. B., Jacques, C., Bedi, G., Silvestre, V., Loquet, D., Barillé-Nion, S., Robins, R. J., & Tea, I. (2013). Phytochemicals isolated from leaves of Chromolaena odorata: impact on viability and clonogenicity of cancer cell lines. Phytotherapy Research : PTR, 27(6), 835-40. https://doi.org/10.1002/ptr.4787
Kouamé PB, et al. Phytochemicals Isolated From Leaves of Chromolaena Odorata: Impact On Viability and Clonogenicity of Cancer Cell Lines. Phytother Res. 2013;27(6):835-40. PubMed PMID: 22899281.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Phytochemicals isolated from leaves of Chromolaena odorata: impact on viability and clonogenicity of cancer cell lines. AU - Kouamé,Prevost Bi-Koffi, AU - Jacques,Camille, AU - Bedi,Gustave, AU - Silvestre,Virginie, AU - Loquet,Denis, AU - Barillé-Nion,Sophie, AU - Robins,Richard J, AU - Tea,Illa, Y1 - 2012/08/16/ PY - 2012/03/26/received PY - 2012/06/26/revised PY - 2012/07/11/accepted PY - 2012/8/18/entrez PY - 2012/8/18/pubmed PY - 2013/10/25/medline SP - 835 EP - 40 JF - Phytotherapy research : PTR JO - Phytother Res VL - 27 IS - 6 N2 - The leaves of Chromolaena odorata (Asteraceae) are exploited extensively in West and Central African ethnopharmacy for the treatment of a wide range of conditions, despite this being a non-native species established in the last 50 years. With the objective of seeking bioactive principles, the nonvolatile compounds, an ethanolic (80% v/v) extract was made and fractionated. From the hexane-soluble fraction, three compounds were isolated. Two of these, 5-hydroxy-7,4'-dimethoxyflavanone and 2'-hydroxy-4,4',5',6'-tetramethoxychalcone, have previously been identified in C. odorata leaves. The third was fully characterised spectroscopically and found to be 1,6-dimethyl-4-(1-methylethyl)naphthalene (cadalene), not previously isolated from the Asteraceae. All three compounds were tested for their cytotoxicity and anticancer properties. 2'-Hydroxy-4,4',5',6'-tetramethoxychalcone was found to be both cytotoxic and anticlonogenic at 20 µm in cell lines Cal51, MCF7 and MDAMB-468, and to act synergistically with the Bcl2 inhibitor ABT737 to enhance apoptosis in Cal51 breast cancer cells. SN - 1099-1573 UR - https://www.unboundmedicine.com/medline/citation/22899281/Phytochemicals_isolated_from_leaves_of_Chromolaena_odorata:_impact_on_viability_and_clonogenicity_of_cancer_cell_lines_ L2 - https://doi.org/10.1002/ptr.4787 DB - PRIME DP - Unbound Medicine ER -