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Determination of chlorpheniramine maleate, dihydrocodeine bitartrate and ephedrine hydrochloride in cough mixture by derivative and differential spectrometry.
J Pharm Belg. 1990 Jul-Aug; 45(4):252-8.JP

Abstract

A method is presented for the determination of chlorpheniramine maleate, dihydrocodeine bitartrate and ephedrine hydrochloride in a three-component mixture without prior separation. Chlorpheniramine maleate was determined by the first and second derivative-differential spectrophotometry, while dihydrocodeine bitartrate was directly determined using first and second derivative measurements. Ephedrine hydrochloride could be determined by first and second derivative spectrophotometry after its oxidation with sodium metaperiodate. The method was proved using synthetic mixtures of these drugs and was applied for their determination in syrup with a coefficient of variation less than 2%.

Authors+Show Affiliations

Korany MA
Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, University of Alexandria, Egypt.
Bedair MM
No affiliation info available
el-Gindy A
No affiliation info available

MeSH

Antitussive AgentsChlorpheniramineCodeineDrug CombinationsEphedrineIndicators and ReagentsSpectrophotometry, Ultraviolet

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2290120

Citation

Korany, M A., et al. "Determination of Chlorpheniramine Maleate, Dihydrocodeine Bitartrate and Ephedrine Hydrochloride in Cough Mixture By Derivative and Differential Spectrometry." Journal De Pharmacie De Belgique, vol. 45, no. 4, 1990, pp. 252-8.
Korany MA, Bedair MM, el-Gindy A. Determination of chlorpheniramine maleate, dihydrocodeine bitartrate and ephedrine hydrochloride in cough mixture by derivative and differential spectrometry. J Pharm Belg. 1990;45(4):252-8.
Korany, M. A., Bedair, M. M., & el-Gindy, A. (1990). Determination of chlorpheniramine maleate, dihydrocodeine bitartrate and ephedrine hydrochloride in cough mixture by derivative and differential spectrometry. Journal De Pharmacie De Belgique, 45(4), 252-8.
Korany MA, Bedair MM, el-Gindy A. Determination of Chlorpheniramine Maleate, Dihydrocodeine Bitartrate and Ephedrine Hydrochloride in Cough Mixture By Derivative and Differential Spectrometry. J Pharm Belg. 1990 Jul-Aug;45(4):252-8. PubMed PMID: 2290120.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Determination of chlorpheniramine maleate, dihydrocodeine bitartrate and ephedrine hydrochloride in cough mixture by derivative and differential spectrometry. AU - Korany,M A, AU - Bedair,M M, AU - el-Gindy,A, PY - 1990/7/1/pubmed PY - 1990/7/1/medline PY - 1990/7/1/entrez SP - 252 EP - 8 JF - Journal de pharmacie de Belgique JO - J Pharm Belg VL - 45 IS - 4 N2 - A method is presented for the determination of chlorpheniramine maleate, dihydrocodeine bitartrate and ephedrine hydrochloride in a three-component mixture without prior separation. Chlorpheniramine maleate was determined by the first and second derivative-differential spectrophotometry, while dihydrocodeine bitartrate was directly determined using first and second derivative measurements. Ephedrine hydrochloride could be determined by first and second derivative spectrophotometry after its oxidation with sodium metaperiodate. The method was proved using synthetic mixtures of these drugs and was applied for their determination in syrup with a coefficient of variation less than 2%. SN - 0047-2166 UR - https://www.unboundmedicine.com/medline/citation/2290120/Determination_of_chlorpheniramine_maleate_dihydrocodeine_bitartrate_and_ephedrine_hydrochloride_in_cough_mixture_by_derivative_and_differential_spectrometry_ DB - PRIME DP - Unbound Medicine ER -

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