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Amebic infection in humans.
Indian J Gastroenterol. 2012 Jul; 31(4):153-62.IJ

Abstract

Clinical human infections with the protozoa Entamoeba histolytica is still estimated to occur in 50 million people worldwide, of which approximately 100,000 die annually. Although most clinical symptoms are due to involvement of the large intestine, 1 % present with involvement of the liver in the form of a liver abscess, a potentially fatal condition. Distinguishing an invasive form (E. histolytica) from a morphologically identical non-invasive one (E. dispar) requires molecular or enzymatic characterization. Further, the pattern of infection, interpretation of presence of antibodies in the host, manifestations of disease, approach to investigations and strategies for management remain complex. This article also provides a comprehensive review of the parasite and host factors that govern the complex relationship of the prozoa and humans, and tries to explain why some develop a particular form of the disease in endemic zones. Application of modern imaging and image guided therapy seems to be playing a major role in diagnosis and management of the potentially most serious form of the disease, amebic liver abscess. Despite lack of controlled studies there is a tendency to lower the threshold of their use in clinical practice, and indeed in-hospital mortality rate seems to be falling for amebic liver abscess. In a world getting increasingly swamped by non-infectious metabolic diseases, awareness of amebic infections, its bed-side diagnosis, the use of appropriate laboratory tests, and decision making in management are shrinking. This review tries to update the scientific developments in amebiasis.

Authors+Show Affiliations

Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226 014, India. choudhuri.gour@gmail.comNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

22903366

Citation

Choudhuri, Gourdas, and Murali Rangan. "Amebic Infection in Humans." Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology, vol. 31, no. 4, 2012, pp. 153-62.
Choudhuri G, Rangan M. Amebic infection in humans. Indian J Gastroenterol. 2012;31(4):153-62.
Choudhuri, G., & Rangan, M. (2012). Amebic infection in humans. Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology, 31(4), 153-62.
Choudhuri G, Rangan M. Amebic Infection in Humans. Indian J Gastroenterol. 2012;31(4):153-62. PubMed PMID: 22903366.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Amebic infection in humans. AU - Choudhuri,Gourdas, AU - Rangan,Murali, Y1 - 2012/08/19/ PY - 2012/01/19/received PY - 2012/05/21/accepted PY - 2012/8/21/entrez PY - 2012/8/21/pubmed PY - 2013/2/28/medline SP - 153 EP - 62 JF - Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology JO - Indian J Gastroenterol VL - 31 IS - 4 N2 - Clinical human infections with the protozoa Entamoeba histolytica is still estimated to occur in 50 million people worldwide, of which approximately 100,000 die annually. Although most clinical symptoms are due to involvement of the large intestine, 1 % present with involvement of the liver in the form of a liver abscess, a potentially fatal condition. Distinguishing an invasive form (E. histolytica) from a morphologically identical non-invasive one (E. dispar) requires molecular or enzymatic characterization. Further, the pattern of infection, interpretation of presence of antibodies in the host, manifestations of disease, approach to investigations and strategies for management remain complex. This article also provides a comprehensive review of the parasite and host factors that govern the complex relationship of the prozoa and humans, and tries to explain why some develop a particular form of the disease in endemic zones. Application of modern imaging and image guided therapy seems to be playing a major role in diagnosis and management of the potentially most serious form of the disease, amebic liver abscess. Despite lack of controlled studies there is a tendency to lower the threshold of their use in clinical practice, and indeed in-hospital mortality rate seems to be falling for amebic liver abscess. In a world getting increasingly swamped by non-infectious metabolic diseases, awareness of amebic infections, its bed-side diagnosis, the use of appropriate laboratory tests, and decision making in management are shrinking. This review tries to update the scientific developments in amebiasis. SN - 0975-0711 UR - https://www.unboundmedicine.com/medline/citation/22903366/full_citation L2 - https://dx.doi.org/10.1007/s12664-012-0192-2 DB - PRIME DP - Unbound Medicine ER -