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Birth defects in infants born in 1998-2004 to men and women serving in the U.S. military during the 1990-1991 Gulf War era.
Birth Defects Res A Clin Mol Teratol. 2012 Sep; 94(9):721-8.BD

Abstract

BACKGROUND

Concerns about reproductive health persist among U.S. military members who served in the 1990-1991 Gulf War. This study explores the long-term impact of 1990-1991 Gulf War deployment on the prevalence of birth defects among infants of Gulf War veterans.

METHODS

Health care data from the Department of Defense Birth and Infant Health Registry and demographic and deployment information from the Defense Manpower Data Center were used to identify infants born between 1998 and 2004 to both male and female 1990-1991 Gulf War veterans. Multivariable logistic regression models estimated the adjusted odds of any birth defect and eight specific birth defects among infants of deployers versus non-deployers. In addition, birth defects were evaluated among infants born to 1990-1991 Gulf War veterans with deployment-specific exposures.

RESULTS

Among 178,766 infants identified for these analyses, 3.4% were diagnosed with a birth defect in the first year of life. Compared to infants of non-deployers, infants of deployers were not at increased odds of being diagnosed with a birth defect, or any of eight specific birth defects, in the first year of life. A slightly increased prevalence of birth defects was observed among infants born to men who deployed to the 1990-1991 Gulf War for 153 to 200 days compared to those who deployed for 1 to 92 days. No other deployment-specific exposures were associated with birth defects in these infants.

CONCLUSIONS

The 1990-1991 Gulf War deployers, including those with specific exposures of concern, were not found to be at increased risk for having infants with birth defects 7 to 14 years after deployment.

Authors+Show Affiliations

Deployment Health Research Department, Naval Health Research Center, San Diego, California 92106-3521, USA. anna.bukowinski@med.navy.milNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

22903974

Citation

Bukowinski, Anna T., et al. "Birth Defects in Infants Born in 1998-2004 to Men and Women Serving in the U.S. Military During the 1990-1991 Gulf War Era." Birth Defects Research. Part A, Clinical and Molecular Teratology, vol. 94, no. 9, 2012, pp. 721-8.
Bukowinski AT, DeScisciolo C, Conlin AM, et al. Birth defects in infants born in 1998-2004 to men and women serving in the U.S. military during the 1990-1991 Gulf War era. Birth Defects Res A Clin Mol Teratol. 2012;94(9):721-8.
Bukowinski, A. T., DeScisciolo, C., Conlin, A. M., K Ryan, M. A., Sevick, C. J., & Smith, T. C. (2012). Birth defects in infants born in 1998-2004 to men and women serving in the U.S. military during the 1990-1991 Gulf War era. Birth Defects Research. Part A, Clinical and Molecular Teratology, 94(9), 721-8. https://doi.org/10.1002/bdra.23062
Bukowinski AT, et al. Birth Defects in Infants Born in 1998-2004 to Men and Women Serving in the U.S. Military During the 1990-1991 Gulf War Era. Birth Defects Res A Clin Mol Teratol. 2012;94(9):721-8. PubMed PMID: 22903974.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Birth defects in infants born in 1998-2004 to men and women serving in the U.S. military during the 1990-1991 Gulf War era. AU - Bukowinski,Anna T, AU - DeScisciolo,Connie, AU - Conlin,Ava Marie S, AU - K Ryan,Margaret A, AU - Sevick,Carter J, AU - Smith,Tyler C, Y1 - 2012/08/18/ PY - 2012/02/29/received PY - 2012/06/14/revised PY - 2012/06/20/accepted PY - 2012/8/21/entrez PY - 2012/8/21/pubmed PY - 2013/6/20/medline SP - 721 EP - 8 JF - Birth defects research. Part A, Clinical and molecular teratology JO - Birth Defects Res A Clin Mol Teratol VL - 94 IS - 9 N2 - BACKGROUND: Concerns about reproductive health persist among U.S. military members who served in the 1990-1991 Gulf War. This study explores the long-term impact of 1990-1991 Gulf War deployment on the prevalence of birth defects among infants of Gulf War veterans. METHODS: Health care data from the Department of Defense Birth and Infant Health Registry and demographic and deployment information from the Defense Manpower Data Center were used to identify infants born between 1998 and 2004 to both male and female 1990-1991 Gulf War veterans. Multivariable logistic regression models estimated the adjusted odds of any birth defect and eight specific birth defects among infants of deployers versus non-deployers. In addition, birth defects were evaluated among infants born to 1990-1991 Gulf War veterans with deployment-specific exposures. RESULTS: Among 178,766 infants identified for these analyses, 3.4% were diagnosed with a birth defect in the first year of life. Compared to infants of non-deployers, infants of deployers were not at increased odds of being diagnosed with a birth defect, or any of eight specific birth defects, in the first year of life. A slightly increased prevalence of birth defects was observed among infants born to men who deployed to the 1990-1991 Gulf War for 153 to 200 days compared to those who deployed for 1 to 92 days. No other deployment-specific exposures were associated with birth defects in these infants. CONCLUSIONS: The 1990-1991 Gulf War deployers, including those with specific exposures of concern, were not found to be at increased risk for having infants with birth defects 7 to 14 years after deployment. SN - 1542-0760 UR - https://www.unboundmedicine.com/medline/citation/22903974/Birth_defects_in_infants_born_in_1998_2004_to_men_and_women_serving_in_the_U_S__military_during_the_1990_1991_Gulf_War_era_ L2 - https://doi.org/10.1002/bdra.23062 DB - PRIME DP - Unbound Medicine ER -