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A randomized, placebo-controlled trial of acupuncture in patients with chronic obstructive pulmonary disease (COPD): the COPD-acupuncture trial (CAT).
Arch Intern Med. 2012 Jun 11; 172(11):878-86.AI

Abstract

BACKGROUND

Dyspnea on exertion (DOE) is a major symptom of chronic obstructive pulmonary disease (COPD) and is difficult to control. This study was performed to determine whether acupuncture is superior to placebo needling in improving DOE in patients with COPD who are receiving standard medication.

METHODS

Sixty-eight of 111 patients from the Kansai region of Japan who were diagnosed as having COPD and were receiving standard medication participated in a randomized, parallel-group, placebo-controlled trial (July 1, 2006, through March 31, 2009) in which the patients, evaluators, and statistician were unaware of the random allocation. Participants were randomly assigned to traditional acupuncture (real acupuncture group, n=34) or placebo needling (placebo acupuncture group, n=34). Both groups received real or placebo needling at the same acupoints once a week for 12 weeks. The primary end point was the modified Borg scale score evaluated immediately after the 6-minute walk test. Measurements were obtained at baseline and after 12 weeks of treatment.

RESULT

After 12 weeks, the Borg scale score after the 6-minute walk test was significantly better in the real acupuncture group compared with the placebo acupuncture group (mean [SD] difference from baseline by analysis of covariance, -3.6 [1.9] vs 0.4 [1.2]; mean difference between groups by analysis of covariance, -3.58; 95% CI, -4.27 to -2.90). Patients with COPD who received real acupuncture also experienced improvement in the 6-minute walk distance during exercise, indicating better exercise tolerance and reduced DOE.

CONCLUSION

This study clearly demonstrates that acupuncture is a useful adjunctive therapy in reducing DOE in patients with COPD.

TRIAL REGISTRATION

umin.ac.jp/ctr Identifier: UMIN000001277.

Authors+Show Affiliations

Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Japan. masuzuki@meiji-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22905352

Citation

Suzuki, Masao, et al. "A Randomized, Placebo-controlled Trial of Acupuncture in Patients With Chronic Obstructive Pulmonary Disease (COPD): the COPD-acupuncture Trial (CAT)." Archives of Internal Medicine, vol. 172, no. 11, 2012, pp. 878-86.
Suzuki M, Muro S, Ando Y, et al. A randomized, placebo-controlled trial of acupuncture in patients with chronic obstructive pulmonary disease (COPD): the COPD-acupuncture trial (CAT). Arch Intern Med. 2012;172(11):878-86.
Suzuki, M., Muro, S., Ando, Y., Omori, T., Shiota, T., Endo, K., Sato, S., Aihara, K., Matsumoto, M., Suzuki, S., Itotani, R., Ishitoko, M., Hara, Y., Takemura, M., Ueda, T., Kagioka, H., Hirabayashi, M., Fukui, M., & Mishima, M. (2012). A randomized, placebo-controlled trial of acupuncture in patients with chronic obstructive pulmonary disease (COPD): the COPD-acupuncture trial (CAT). Archives of Internal Medicine, 172(11), 878-86.
Suzuki M, et al. A Randomized, Placebo-controlled Trial of Acupuncture in Patients With Chronic Obstructive Pulmonary Disease (COPD): the COPD-acupuncture Trial (CAT). Arch Intern Med. 2012 Jun 11;172(11):878-86. PubMed PMID: 22905352.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A randomized, placebo-controlled trial of acupuncture in patients with chronic obstructive pulmonary disease (COPD): the COPD-acupuncture trial (CAT). AU - Suzuki,Masao, AU - Muro,Shigeo, AU - Ando,Yuki, AU - Omori,Takashi, AU - Shiota,Tetsuhiro, AU - Endo,Kazuo, AU - Sato,Susumu, AU - Aihara,Kensaku, AU - Matsumoto,Masataka, AU - Suzuki,Shinko, AU - Itotani,Ryo, AU - Ishitoko,Manabu, AU - Hara,Yoshikazu, AU - Takemura,Masaya, AU - Ueda,Tetsuya, AU - Kagioka,Hitoshi, AU - Hirabayashi,Masataka, AU - Fukui,Motonari, AU - Mishima,Michiaki, PY - 2012/8/21/entrez PY - 2012/8/21/pubmed PY - 2012/8/25/medline SP - 878 EP - 86 JF - Archives of internal medicine JO - Arch Intern Med VL - 172 IS - 11 N2 - BACKGROUND: Dyspnea on exertion (DOE) is a major symptom of chronic obstructive pulmonary disease (COPD) and is difficult to control. This study was performed to determine whether acupuncture is superior to placebo needling in improving DOE in patients with COPD who are receiving standard medication. METHODS: Sixty-eight of 111 patients from the Kansai region of Japan who were diagnosed as having COPD and were receiving standard medication participated in a randomized, parallel-group, placebo-controlled trial (July 1, 2006, through March 31, 2009) in which the patients, evaluators, and statistician were unaware of the random allocation. Participants were randomly assigned to traditional acupuncture (real acupuncture group, n=34) or placebo needling (placebo acupuncture group, n=34). Both groups received real or placebo needling at the same acupoints once a week for 12 weeks. The primary end point was the modified Borg scale score evaluated immediately after the 6-minute walk test. Measurements were obtained at baseline and after 12 weeks of treatment. RESULT: After 12 weeks, the Borg scale score after the 6-minute walk test was significantly better in the real acupuncture group compared with the placebo acupuncture group (mean [SD] difference from baseline by analysis of covariance, -3.6 [1.9] vs 0.4 [1.2]; mean difference between groups by analysis of covariance, -3.58; 95% CI, -4.27 to -2.90). Patients with COPD who received real acupuncture also experienced improvement in the 6-minute walk distance during exercise, indicating better exercise tolerance and reduced DOE. CONCLUSION: This study clearly demonstrates that acupuncture is a useful adjunctive therapy in reducing DOE in patients with COPD. TRIAL REGISTRATION: umin.ac.jp/ctr Identifier: UMIN000001277. SN - 1538-3679 UR - https://www.unboundmedicine.com/medline/citation/22905352/A_randomized_placebo_controlled_trial_of_acupuncture_in_patients_with_chronic_obstructive_pulmonary_disease__COPD_:_the_COPD_acupuncture_trial__CAT__ L2 - https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/10.1001/archinternmed.2012.1233 DB - PRIME DP - Unbound Medicine ER -