Tags

Type your tag names separated by a space and hit enter

Palladium-assisted regioselective C-H cyanation of heteroarenes using isonitrile as cyanide source.
Org Lett. 2012 Sep 07; 14(17):4614-7.OL

Abstract

A palladium-catalyzed regioselective C-H cyanation of heteroarenes was achieved using tert-butyl isocyanide as "CN" source, which provides a new and unique strategy for the preparation of (hetero)aryl nitriles. Indoles, pyrroles, and aromatic rings could be efficiently cyanated through C-H bond activation with high regioselectivity.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Xu S
Department of Chemistry, Shanghai University, Shanghai 200444, China.
Huang X
No affiliation info available
Hong X
No affiliation info available
Xu B
No affiliation info available

MeSH

CatalysisIndolesMolecular StructureNitrilesPalladiumPyridinesPyrimidinesPyrrolesStereoisomerism

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22905784

Citation

Xu, Shuguang, et al. "Palladium-assisted Regioselective C-H Cyanation of Heteroarenes Using Isonitrile as Cyanide Source." Organic Letters, vol. 14, no. 17, 2012, pp. 4614-7.
Xu S, Huang X, Hong X, et al. Palladium-assisted regioselective C-H cyanation of heteroarenes using isonitrile as cyanide source. Org Lett. 2012;14(17):4614-7.
Xu, S., Huang, X., Hong, X., & Xu, B. (2012). Palladium-assisted regioselective C-H cyanation of heteroarenes using isonitrile as cyanide source. Organic Letters, 14(17), 4614-7. https://doi.org/10.1021/ol302070t
Xu S, et al. Palladium-assisted Regioselective C-H Cyanation of Heteroarenes Using Isonitrile as Cyanide Source. Org Lett. 2012 Sep 7;14(17):4614-7. PubMed PMID: 22905784.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Palladium-assisted regioselective C-H cyanation of heteroarenes using isonitrile as cyanide source. AU - Xu,Shuguang, AU - Huang,Xiaomei, AU - Hong,Xiaohu, AU - Xu,Bin, Y1 - 2012/08/20/ PY - 2012/8/22/entrez PY - 2012/8/22/pubmed PY - 2013/4/6/medline SP - 4614 EP - 7 JF - Organic letters JO - Org Lett VL - 14 IS - 17 N2 - A palladium-catalyzed regioselective C-H cyanation of heteroarenes was achieved using tert-butyl isocyanide as "CN" source, which provides a new and unique strategy for the preparation of (hetero)aryl nitriles. Indoles, pyrroles, and aromatic rings could be efficiently cyanated through C-H bond activation with high regioselectivity. SN - 1523-7052 UR - https://www.unboundmedicine.com/medline/citation/22905784/Palladium_assisted_regioselective_C_H_cyanation_of_heteroarenes_using_isonitrile_as_cyanide_source_ L2 - https://doi.org/10.1021/ol302070t DB - PRIME DP - Unbound Medicine ER -