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Skin phototoxicity of cosmetic formulations containing photounstable and photostable UV-filters and vitamin A palmitate.
Toxicol In Vitro. 2013 Feb; 27(1):418-25.TV

Abstract

The aim of this study was to evaluate the in vitro skin phototoxicity of cosmetic formulations containing photounstable and photostable UV-filters and vitamin A palmitate, assessed by two in vitro techniques: 3T3 Neutral Red Uptake Phototoxicity Test and Human 3-D Skin Model In Vitro Phototoxicity Test. For this, four different formulations containing vitamin A palmitate and different UV-filters combinations, two of them considered photostable and two of them considered photounstable, were prepared. Solutions of each UV-filter and vitamin under study and solutions of four different combinations under study were also prepared. The phototoxicity was assessed in vitro by the 3T3 NRU phototoxicity test (3T3-NRU-PT) and subsequently in a phototoxicity test on reconstructed human skin model (H3D-PT). Avobenzone presented a pronounced phototoxicity and vitamin A presented a tendency to a weak phototoxic potential. A synergistic effect of vitamin A palmitate on the phototoxicity of combinations containing avobenzone was observed. H3D-PT results did not confirm the positive 3T3-NRU-PT results. However, despite the four formulations studied did not present any acute phototoxicity potential, the combination 2 containing octyl methoxycinnamate (OMC), avobenzone (AVB) and 4-methylbenzilidene camphor (MBC) presented an indication of phototoxicity that should be better investigated in terms of the frequency of photoallergic or chronic phototoxicity in humans, once these tests are scientifically validated only to detect phototoxic potential with the aim of preventing phototoxic reactions in the general population, and positive results cannot predict the exact incidence of phototoxic reactions in humans.

Authors+Show Affiliations

University of Sao Paulo, Faculty of Pharmaceutical Sciences of Ribeirao Preto, SP, Brazil. lorena@fcfrp.usp.brNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22906567

Citation

Gaspar, Lorena R., et al. "Skin Phototoxicity of Cosmetic Formulations Containing Photounstable and Photostable UV-filters and Vitamin a Palmitate." Toxicology in Vitro : an International Journal Published in Association With BIBRA, vol. 27, no. 1, 2013, pp. 418-25.
Gaspar LR, Tharmann J, Maia Campos PM, et al. Skin phototoxicity of cosmetic formulations containing photounstable and photostable UV-filters and vitamin A palmitate. Toxicol In Vitro. 2013;27(1):418-25.
Gaspar, L. R., Tharmann, J., Maia Campos, P. M., & Liebsch, M. (2013). Skin phototoxicity of cosmetic formulations containing photounstable and photostable UV-filters and vitamin A palmitate. Toxicology in Vitro : an International Journal Published in Association With BIBRA, 27(1), 418-25. https://doi.org/10.1016/j.tiv.2012.08.006
Gaspar LR, et al. Skin Phototoxicity of Cosmetic Formulations Containing Photounstable and Photostable UV-filters and Vitamin a Palmitate. Toxicol In Vitro. 2013;27(1):418-25. PubMed PMID: 22906567.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Skin phototoxicity of cosmetic formulations containing photounstable and photostable UV-filters and vitamin A palmitate. AU - Gaspar,Lorena R, AU - Tharmann,Julian, AU - Maia Campos,Patricia M B G, AU - Liebsch,Manfred, Y1 - 2012/08/10/ PY - 2012/01/10/received PY - 2012/07/31/revised PY - 2012/08/02/accepted PY - 2012/8/22/entrez PY - 2012/8/22/pubmed PY - 2013/9/18/medline SP - 418 EP - 25 JF - Toxicology in vitro : an international journal published in association with BIBRA JO - Toxicol In Vitro VL - 27 IS - 1 N2 - The aim of this study was to evaluate the in vitro skin phototoxicity of cosmetic formulations containing photounstable and photostable UV-filters and vitamin A palmitate, assessed by two in vitro techniques: 3T3 Neutral Red Uptake Phototoxicity Test and Human 3-D Skin Model In Vitro Phototoxicity Test. For this, four different formulations containing vitamin A palmitate and different UV-filters combinations, two of them considered photostable and two of them considered photounstable, were prepared. Solutions of each UV-filter and vitamin under study and solutions of four different combinations under study were also prepared. The phototoxicity was assessed in vitro by the 3T3 NRU phototoxicity test (3T3-NRU-PT) and subsequently in a phototoxicity test on reconstructed human skin model (H3D-PT). Avobenzone presented a pronounced phototoxicity and vitamin A presented a tendency to a weak phototoxic potential. A synergistic effect of vitamin A palmitate on the phototoxicity of combinations containing avobenzone was observed. H3D-PT results did not confirm the positive 3T3-NRU-PT results. However, despite the four formulations studied did not present any acute phototoxicity potential, the combination 2 containing octyl methoxycinnamate (OMC), avobenzone (AVB) and 4-methylbenzilidene camphor (MBC) presented an indication of phototoxicity that should be better investigated in terms of the frequency of photoallergic or chronic phototoxicity in humans, once these tests are scientifically validated only to detect phototoxic potential with the aim of preventing phototoxic reactions in the general population, and positive results cannot predict the exact incidence of phototoxic reactions in humans. SN - 1879-3177 UR - https://www.unboundmedicine.com/medline/citation/22906567/Skin_phototoxicity_of_cosmetic_formulations_containing_photounstable_and_photostable_UV_filters_and_vitamin_A_palmitate_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0887-2333(12)00210-X DB - PRIME DP - Unbound Medicine ER -