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Mitochondria of trained skeletal muscle are protected from deleterious effects of statins.
Muscle Nerve. 2012 Sep; 46(3):367-73.MN

Abstract

INTRODUCTION

Statins are associated with adverse skeletal muscle effects. Our objective was to determine if muscular adaptations following exercise training prevented deleterious effects of atorvastatin in glycolytic skeletal muscle.

METHODS

Twenty rats were divided into 2 groups: a control group (n = 10; Cont) and a 10 days of training group (n = 10; Training). Using the permeabilized fibers technique, we explored mitochondrial function.

RESULTS

Exercise training increased V(max) and H(2)O(2) production without altering the free radical leak, and mRNA expression of SOD2 and Cox1 were higher in trained muscle. In the Cont group, atorvastatin exposure increased H(2)O(2) production and decreased skeletal muscle V(max). The decreased V(max) effect of atorvastatin was dose dependent. Interestingly, the half-maximal inhibitory concentration (IC(50)) was higher in the Training group. H(2)O(2) production increased in trained muscle after atorvastatin exposure.

CONCLUSIONS

These results suggest that improvements in mitochondrial respiratory and antioxidant capacities following endurance training protected mitochondria against statin exposure.

Authors+Show Affiliations

CHRU of Strasbourg, Physiology and Functional Explorations Department, New Civil Hospital, B.P. 426, 67091 Strasbourg, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22907227

Citation

Bouitbir, Jamal, et al. "Mitochondria of Trained Skeletal Muscle Are Protected From Deleterious Effects of Statins." Muscle & Nerve, vol. 46, no. 3, 2012, pp. 367-73.
Bouitbir J, Daussin F, Charles AL, et al. Mitochondria of trained skeletal muscle are protected from deleterious effects of statins. Muscle Nerve. 2012;46(3):367-73.
Bouitbir, J., Daussin, F., Charles, A. L., Rasseneur, L., Dufour, S., Richard, R., Piquard, F., Geny, B., & Zoll, J. (2012). Mitochondria of trained skeletal muscle are protected from deleterious effects of statins. Muscle & Nerve, 46(3), 367-73. https://doi.org/10.1002/mus.23309
Bouitbir J, et al. Mitochondria of Trained Skeletal Muscle Are Protected From Deleterious Effects of Statins. Muscle Nerve. 2012;46(3):367-73. PubMed PMID: 22907227.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mitochondria of trained skeletal muscle are protected from deleterious effects of statins. AU - Bouitbir,Jamal, AU - Daussin,Frédéric, AU - Charles,Anne-Laure, AU - Rasseneur,Laurence, AU - Dufour,Stéphane, AU - Richard,Ruddy, AU - Piquard,François, AU - Geny,Bernard, AU - Zoll,Joffrey, PY - 2012/8/22/entrez PY - 2012/8/22/pubmed PY - 2012/11/7/medline SP - 367 EP - 73 JF - Muscle & nerve JO - Muscle Nerve VL - 46 IS - 3 N2 - INTRODUCTION: Statins are associated with adverse skeletal muscle effects. Our objective was to determine if muscular adaptations following exercise training prevented deleterious effects of atorvastatin in glycolytic skeletal muscle. METHODS: Twenty rats were divided into 2 groups: a control group (n = 10; Cont) and a 10 days of training group (n = 10; Training). Using the permeabilized fibers technique, we explored mitochondrial function. RESULTS: Exercise training increased V(max) and H(2)O(2) production without altering the free radical leak, and mRNA expression of SOD2 and Cox1 were higher in trained muscle. In the Cont group, atorvastatin exposure increased H(2)O(2) production and decreased skeletal muscle V(max). The decreased V(max) effect of atorvastatin was dose dependent. Interestingly, the half-maximal inhibitory concentration (IC(50)) was higher in the Training group. H(2)O(2) production increased in trained muscle after atorvastatin exposure. CONCLUSIONS: These results suggest that improvements in mitochondrial respiratory and antioxidant capacities following endurance training protected mitochondria against statin exposure. SN - 1097-4598 UR - https://www.unboundmedicine.com/medline/citation/22907227/Mitochondria_of_trained_skeletal_muscle_are_protected_from_deleterious_effects_of_statins_ L2 - https://doi.org/10.1002/mus.23309 DB - PRIME DP - Unbound Medicine ER -