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Phytoestrogen intake from foods, during adolescence and adulthood, and risk of breast cancer by estrogen and progesterone receptor tumor subgroup among Ontario women.

Abstract

Phytoestrogen intake may reduce breast cancer risk and limited evidence suggests this association may hold for hormone receptor-positive tumors only. The study aims were to assess whether the association between phytoestrogen intake during adolescence and adulthood and breast cancer risk varies by estrogen and progesterone receptor (ERPR) tumor subgroup. Cases were identified from the Ontario Cancer Registry (2002-2003), and ERPR status was ascertained from pathology reports for 81% of cases (n = 2,438). Controls were identified through random digit dialing of Ontario households (n = 3,370). Published phytoestrogen food values were applied to food frequency questionnaire responses to assess isoflavone, lignan and total phytoestrogen intake, during adolescence and adulthood. Polytomous multivariate logistic regression was used to estimate adjusted odds ratios (ORs) for association between phytoestrogen intake and breast cancer risk by hormone receptor ERPR tumor subgroups. Among premenopausal women, few associations were observed for adolescent or adult phytoestrogen intake across all tumor subgroups. Among postmenopausal women, adolescent phytoestrogen intake (isoflavone, lignan and total) was associated with reduced risk across all hormone receptor subgroups; however, statistical significance was most consistent within the ER+PR+ subgroup. For example, ER+PR+ postmenopausal breast cancer risk was associated with adolescent phytoestrogen intake (highest vs. lowest: OR = 0.79; 95% confidence interval: 0.65-0.96). Among all women and postmenopausal women, ORs for high adult lignan intake were all below 1.0 within each tumor subgroup, suggesting reduced breast cancer risk, although none reached statistical significance. In conclusion, adolescent phytoestrogen intake was associated with reduced postmenopausal breast cancer, particularly for ER+PR+ tumor subgroup.

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  • Authors+Show Affiliations

    ,

    Prevention and Cancer Control, Cancer Care Ontario, Toronto, ON, Canada. LN.Anderson@utoronto.ca

    , ,

    Source

    International journal of cancer 132:7 2013 Apr 01 pg 1683-92

    MeSH

    Adolescent
    Adult
    Aged
    Breast Neoplasms
    Case-Control Studies
    Female
    Humans
    Incidence
    Middle Aged
    Odds Ratio
    Ontario
    Phytoestrogens
    Postmenopause
    Premenopause
    Prognosis
    Prospective Studies
    Receptors, Estrogen
    Receptors, Progesterone
    Risk Factors
    Surveys and Questionnaires

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    22907507

    Citation

    Anderson, Laura N., et al. "Phytoestrogen Intake From Foods, During Adolescence and Adulthood, and Risk of Breast Cancer By Estrogen and Progesterone Receptor Tumor Subgroup Among Ontario Women." International Journal of Cancer, vol. 132, no. 7, 2013, pp. 1683-92.
    Anderson LN, Cotterchio M, Boucher BA, et al. Phytoestrogen intake from foods, during adolescence and adulthood, and risk of breast cancer by estrogen and progesterone receptor tumor subgroup among Ontario women. Int J Cancer. 2013;132(7):1683-92.
    Anderson, L. N., Cotterchio, M., Boucher, B. A., & Kreiger, N. (2013). Phytoestrogen intake from foods, during adolescence and adulthood, and risk of breast cancer by estrogen and progesterone receptor tumor subgroup among Ontario women. International Journal of Cancer, 132(7), pp. 1683-92. doi:10.1002/ijc.27788.
    Anderson LN, et al. Phytoestrogen Intake From Foods, During Adolescence and Adulthood, and Risk of Breast Cancer By Estrogen and Progesterone Receptor Tumor Subgroup Among Ontario Women. Int J Cancer. 2013 Apr 1;132(7):1683-92. PubMed PMID: 22907507.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Phytoestrogen intake from foods, during adolescence and adulthood, and risk of breast cancer by estrogen and progesterone receptor tumor subgroup among Ontario women. AU - Anderson,Laura N, AU - Cotterchio,Michelle, AU - Boucher,Beatrice A, AU - Kreiger,Nancy, Y1 - 2012/09/14/ PY - 2012/02/20/received PY - 2012/07/31/accepted PY - 2012/8/22/entrez PY - 2012/8/22/pubmed PY - 2013/4/5/medline SP - 1683 EP - 92 JF - International journal of cancer JO - Int. J. Cancer VL - 132 IS - 7 N2 - Phytoestrogen intake may reduce breast cancer risk and limited evidence suggests this association may hold for hormone receptor-positive tumors only. The study aims were to assess whether the association between phytoestrogen intake during adolescence and adulthood and breast cancer risk varies by estrogen and progesterone receptor (ERPR) tumor subgroup. Cases were identified from the Ontario Cancer Registry (2002-2003), and ERPR status was ascertained from pathology reports for 81% of cases (n = 2,438). Controls were identified through random digit dialing of Ontario households (n = 3,370). Published phytoestrogen food values were applied to food frequency questionnaire responses to assess isoflavone, lignan and total phytoestrogen intake, during adolescence and adulthood. Polytomous multivariate logistic regression was used to estimate adjusted odds ratios (ORs) for association between phytoestrogen intake and breast cancer risk by hormone receptor ERPR tumor subgroups. Among premenopausal women, few associations were observed for adolescent or adult phytoestrogen intake across all tumor subgroups. Among postmenopausal women, adolescent phytoestrogen intake (isoflavone, lignan and total) was associated with reduced risk across all hormone receptor subgroups; however, statistical significance was most consistent within the ER+PR+ subgroup. For example, ER+PR+ postmenopausal breast cancer risk was associated with adolescent phytoestrogen intake (highest vs. lowest: OR = 0.79; 95% confidence interval: 0.65-0.96). Among all women and postmenopausal women, ORs for high adult lignan intake were all below 1.0 within each tumor subgroup, suggesting reduced breast cancer risk, although none reached statistical significance. In conclusion, adolescent phytoestrogen intake was associated with reduced postmenopausal breast cancer, particularly for ER+PR+ tumor subgroup. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/22907507/Phytoestrogen_intake_from_foods_during_adolescence_and_adulthood_and_risk_of_breast_cancer_by_estrogen_and_progesterone_receptor_tumor_subgroup_among_Ontario_women_ L2 - https://doi.org/10.1002/ijc.27788 DB - PRIME DP - Unbound Medicine ER -