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c-AMP dependent protein kinase A inhibitory activity of six algal extracts from southeastern Australia and their fatty acid composition.
Nat Prod Commun. 2012 Jul; 7(7):923-6.NP

Abstract

c-AMP dependent protein kinase (protein kinase A, PKA) is an important enzyme involved in the regulation of an increasing number of physiological processes including immune function, cardiovascular disease, memory disorders and cancer. The objective of this study was to evaluate the PKA inhibitory activity of a range of algal extracts, along with their fatty acid composition. Six algal species were investigated including two Chlorophyta (Codium dimorphum and Ulva lactuca), two Phaeophyta (Phyllospora comosa and Sargassum sp.) and two Rhodophyta (Prionitis linearis and Corallina vancouveriensis), with the order of PKA inhibitory activity of their extracts identified as follows: brown seaweeds > red seaweeds > green seaweeds with the brown alga Sargassum sp. exhibiting the highest PKA inhibitory activity (84% at 100 microg/mL). GC/MS analysis identified a total of 18 fatty acids in the six algal extracts accounting for 72-87% of each extract, with hexadecanoic acid and 9,12-octadecadienoic acid as the dominant components. The most active extract (Sargassum sp.) also contained the highest percentage of the saturated C14:0 fatty acid (12.8% of the total extract), which is a known to inhibit PKA. These results provide the first description of the PKA inhibitory activity of marine algae along with the first description of the fatty acid composition of these six algal species from South Eastern Australian waters. Importantly, this study reveals that abundant and readily available marine algae are a new and relatively unexplored source of PKA inhibitory compounds.

Authors+Show Affiliations

School of Chemistry, University of Wollongong, NSW, 2500, Australia.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22908583

Citation

Zivanovic, Ana, and Danielle Skropeta. "C-AMP Dependent Protein Kinase a Inhibitory Activity of Six Algal Extracts From Southeastern Australia and Their Fatty Acid Composition." Natural Product Communications, vol. 7, no. 7, 2012, pp. 923-6.
Zivanovic A, Skropeta D. C-AMP dependent protein kinase A inhibitory activity of six algal extracts from southeastern Australia and their fatty acid composition. Nat Prod Commun. 2012;7(7):923-6.
Zivanovic, A., & Skropeta, D. (2012). C-AMP dependent protein kinase A inhibitory activity of six algal extracts from southeastern Australia and their fatty acid composition. Natural Product Communications, 7(7), 923-6.
Zivanovic A, Skropeta D. C-AMP Dependent Protein Kinase a Inhibitory Activity of Six Algal Extracts From Southeastern Australia and Their Fatty Acid Composition. Nat Prod Commun. 2012;7(7):923-6. PubMed PMID: 22908583.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - c-AMP dependent protein kinase A inhibitory activity of six algal extracts from southeastern Australia and their fatty acid composition. AU - Zivanovic,Ana, AU - Skropeta,Danielle, PY - 2012/8/23/entrez PY - 2012/8/23/pubmed PY - 2012/9/21/medline SP - 923 EP - 6 JF - Natural product communications JO - Nat Prod Commun VL - 7 IS - 7 N2 - c-AMP dependent protein kinase (protein kinase A, PKA) is an important enzyme involved in the regulation of an increasing number of physiological processes including immune function, cardiovascular disease, memory disorders and cancer. The objective of this study was to evaluate the PKA inhibitory activity of a range of algal extracts, along with their fatty acid composition. Six algal species were investigated including two Chlorophyta (Codium dimorphum and Ulva lactuca), two Phaeophyta (Phyllospora comosa and Sargassum sp.) and two Rhodophyta (Prionitis linearis and Corallina vancouveriensis), with the order of PKA inhibitory activity of their extracts identified as follows: brown seaweeds > red seaweeds > green seaweeds with the brown alga Sargassum sp. exhibiting the highest PKA inhibitory activity (84% at 100 microg/mL). GC/MS analysis identified a total of 18 fatty acids in the six algal extracts accounting for 72-87% of each extract, with hexadecanoic acid and 9,12-octadecadienoic acid as the dominant components. The most active extract (Sargassum sp.) also contained the highest percentage of the saturated C14:0 fatty acid (12.8% of the total extract), which is a known to inhibit PKA. These results provide the first description of the PKA inhibitory activity of marine algae along with the first description of the fatty acid composition of these six algal species from South Eastern Australian waters. Importantly, this study reveals that abundant and readily available marine algae are a new and relatively unexplored source of PKA inhibitory compounds. SN - 1934-578X UR - https://www.unboundmedicine.com/medline/citation/22908583/c_AMP_dependent_protein_kinase_A_inhibitory_activity_of_six_algal_extracts_from_southeastern_Australia_and_their_fatty_acid_composition_ DB - PRIME DP - Unbound Medicine ER -
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