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Chemical composition and in vitro evaluation of antimicrobial and anti-acetylcholinesterase properties of the flower oil of Ferula lutea.
Nat Prod Commun. 2012 Jul; 7(7):947-50.NP

Abstract

The present work describes the chemical composition and evaluates the antimicrobial and the anti-acetylcholinesterase properties of the flower oil from the Tunisian Ferula lutea obtained by hydrodistillation and analyzed by combination of GC/FID and GC/MS. The chemical composition of the flower oil of this species is reported for the first time. Seventeen compounds were identified accounting for 94.3% of the total oil. The chemical composition of this essential oil was characterized by a high proportion of monoterpene hydrocarbons (80.4%) among which delta-3-carene (31.2%) and alpha-pinene (25.8%) were the predominant compounds. The oxygenated monoterpenes represent the second major fraction (12.0%), 2,3,6-trimethylbenzaldehyde (10.9%) being the predominant one. Furthermore, the isolated oil was tested for its antimicrobial activity using the disc-diffusion and the microdilution assays against six Gram-positive and five Gram-negative bacteria as well as towards eight Candida species. It was found that flower oil of F. lutea exhibited interesting antibacterial and anticandidal activity (MIC = 39 mcirog/mL against Escherichia coli, Staphylococcus aureus and S. epidermidis and MIC = 156 microg/mL against Candida albicans). The anti-acetylcholinesterase effect of this oil was also evaluated in this work. Results showed that this oil exhibits significant activity (IC50 =70.25 +/- 5.41 microg/mL).

Authors+Show Affiliations

Département de Chimie, Faculté des Sciences de Monastir, Universite de Monastir, Avenue de l'Environnement, 5019 Monastir Tunisie.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22908590

Citation

Znati, Mansour, et al. "Chemical Composition and in Vitro Evaluation of Antimicrobial and Anti-acetylcholinesterase Properties of the Flower Oil of Ferula Lutea." Natural Product Communications, vol. 7, no. 7, 2012, pp. 947-50.
Znati M, Jabrane A, Hajlaoui H, et al. Chemical composition and in vitro evaluation of antimicrobial and anti-acetylcholinesterase properties of the flower oil of Ferula lutea. Nat Prod Commun. 2012;7(7):947-50.
Znati, M., Jabrane, A., Hajlaoui, H., Harzallah-Skhiri, F., Bouajila, J., Casanova, J., & Ben Jannet, H. (2012). Chemical composition and in vitro evaluation of antimicrobial and anti-acetylcholinesterase properties of the flower oil of Ferula lutea. Natural Product Communications, 7(7), 947-50.
Znati M, et al. Chemical Composition and in Vitro Evaluation of Antimicrobial and Anti-acetylcholinesterase Properties of the Flower Oil of Ferula Lutea. Nat Prod Commun. 2012;7(7):947-50. PubMed PMID: 22908590.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chemical composition and in vitro evaluation of antimicrobial and anti-acetylcholinesterase properties of the flower oil of Ferula lutea. AU - Znati,Mansour, AU - Jabrane,Aymen, AU - Hajlaoui,Hafedh, AU - Harzallah-Skhiri,Fethia, AU - Bouajila,Jalloul, AU - Casanova,Joseph, AU - Ben Jannet,Hichem, PY - 2012/8/23/entrez PY - 2012/8/23/pubmed PY - 2012/9/21/medline SP - 947 EP - 50 JF - Natural product communications JO - Nat Prod Commun VL - 7 IS - 7 N2 - The present work describes the chemical composition and evaluates the antimicrobial and the anti-acetylcholinesterase properties of the flower oil from the Tunisian Ferula lutea obtained by hydrodistillation and analyzed by combination of GC/FID and GC/MS. The chemical composition of the flower oil of this species is reported for the first time. Seventeen compounds were identified accounting for 94.3% of the total oil. The chemical composition of this essential oil was characterized by a high proportion of monoterpene hydrocarbons (80.4%) among which delta-3-carene (31.2%) and alpha-pinene (25.8%) were the predominant compounds. The oxygenated monoterpenes represent the second major fraction (12.0%), 2,3,6-trimethylbenzaldehyde (10.9%) being the predominant one. Furthermore, the isolated oil was tested for its antimicrobial activity using the disc-diffusion and the microdilution assays against six Gram-positive and five Gram-negative bacteria as well as towards eight Candida species. It was found that flower oil of F. lutea exhibited interesting antibacterial and anticandidal activity (MIC = 39 mcirog/mL against Escherichia coli, Staphylococcus aureus and S. epidermidis and MIC = 156 microg/mL against Candida albicans). The anti-acetylcholinesterase effect of this oil was also evaluated in this work. Results showed that this oil exhibits significant activity (IC50 =70.25 +/- 5.41 microg/mL). SN - 1934-578X UR - https://www.unboundmedicine.com/medline/citation/22908590/Chemical_composition_and_in_vitro_evaluation_of_antimicrobial_and_anti_acetylcholinesterase_properties_of_the_flower_oil_of_Ferula_lutea_ DB - PRIME DP - Unbound Medicine ER -