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Striatal D(2)/D(3) receptor availability is inversely correlated with cannabis consumption in chronic marijuana users.
Drug Alcohol Depend. 2013 Feb 01; 128(1-2):52-7.DA

Abstract

BACKGROUND

Although the incidence of cannabis abuse/dependence in Americans is rising, the neurobiology of cannabis addiction is not well understood. Imaging studies have demonstrated deficits in striatal D(2)/D(3) receptor availability in several substance-dependent populations. However, this has not been studied in currently using chronic cannabis users.

OBJECTIVE

The purpose of this study was to compare striatal D(2)/D(3) receptor availability between currently using chronic cannabis users and healthy controls.

METHODS

Eighteen right-handed males age 18-34 were studied. Ten subjects were chronic cannabis users; eight were demographically matched controls. Subjects underwent a [(11)C]raclopride (RAC) PET scan. Striatal RAC binding potential (BP(ND)) was calculated on a voxel-wise basis. Prior to scanning, urine samples were obtained from cannabis users for quantification of urine Δ-9-tetrahydrocannabinol (THC) and THC metabolites (11-nor-Δ-9-THC-9-carboxylic acid; THC-COOH and 11-hydroxy-THC;OH-THC).

RESULTS

There were no differences in D(2)/D(3) receptor availability between cannabis users and controls. Voxel-wise analyses revealed that RAC BP(ND) values were negatively associated with both urine levels of cannabis metabolites and self-report of recent cannabis consumption.

CONCLUSIONS

In this sample, current cannabis use was not associated with deficits in striatal D(2)/D(3) receptor availability. There was an inverse relationship between chronic cannabis use and striatal RAC BP(ND). Additional studies are needed to identify the neurochemical consequences of chronic cannabis use on the dopamine system.

Authors+Show Affiliations

Indiana University Center for Neuroimaging, Indiana University School of Medicine, Indianapolis, IN 46202, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

22909787

Citation

Albrecht, Daniel S., et al. "Striatal D(2)/D(3) Receptor Availability Is Inversely Correlated With Cannabis Consumption in Chronic Marijuana Users." Drug and Alcohol Dependence, vol. 128, no. 1-2, 2013, pp. 52-7.
Albrecht DS, Skosnik PD, Vollmer JM, et al. Striatal D(2)/D(3) receptor availability is inversely correlated with cannabis consumption in chronic marijuana users. Drug Alcohol Depend. 2013;128(1-2):52-7.
Albrecht, D. S., Skosnik, P. D., Vollmer, J. M., Brumbaugh, M. S., Perry, K. M., Mock, B. H., Zheng, Q. H., Federici, L. A., Patton, E. A., Herring, C. M., & Yoder, K. K. (2013). Striatal D(2)/D(3) receptor availability is inversely correlated with cannabis consumption in chronic marijuana users. Drug and Alcohol Dependence, 128(1-2), 52-7. https://doi.org/10.1016/j.drugalcdep.2012.07.016
Albrecht DS, et al. Striatal D(2)/D(3) Receptor Availability Is Inversely Correlated With Cannabis Consumption in Chronic Marijuana Users. Drug Alcohol Depend. 2013 Feb 1;128(1-2):52-7. PubMed PMID: 22909787.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Striatal D(2)/D(3) receptor availability is inversely correlated with cannabis consumption in chronic marijuana users. AU - Albrecht,Daniel S, AU - Skosnik,Patrick D, AU - Vollmer,Jennifer M, AU - Brumbaugh,Margaret S, AU - Perry,Kevin M, AU - Mock,Bruce H, AU - Zheng,Qi-Huang, AU - Federici,Lauren A, AU - Patton,Elizabeth A, AU - Herring,Christine M, AU - Yoder,Karmen K, Y1 - 2012/08/19/ PY - 2012/03/06/received PY - 2012/05/21/revised PY - 2012/07/29/accepted PY - 2012/8/23/entrez PY - 2012/8/23/pubmed PY - 2013/6/25/medline SP - 52 EP - 7 JF - Drug and alcohol dependence JO - Drug Alcohol Depend VL - 128 IS - 1-2 N2 - BACKGROUND: Although the incidence of cannabis abuse/dependence in Americans is rising, the neurobiology of cannabis addiction is not well understood. Imaging studies have demonstrated deficits in striatal D(2)/D(3) receptor availability in several substance-dependent populations. However, this has not been studied in currently using chronic cannabis users. OBJECTIVE: The purpose of this study was to compare striatal D(2)/D(3) receptor availability between currently using chronic cannabis users and healthy controls. METHODS: Eighteen right-handed males age 18-34 were studied. Ten subjects were chronic cannabis users; eight were demographically matched controls. Subjects underwent a [(11)C]raclopride (RAC) PET scan. Striatal RAC binding potential (BP(ND)) was calculated on a voxel-wise basis. Prior to scanning, urine samples were obtained from cannabis users for quantification of urine Δ-9-tetrahydrocannabinol (THC) and THC metabolites (11-nor-Δ-9-THC-9-carboxylic acid; THC-COOH and 11-hydroxy-THC;OH-THC). RESULTS: There were no differences in D(2)/D(3) receptor availability between cannabis users and controls. Voxel-wise analyses revealed that RAC BP(ND) values were negatively associated with both urine levels of cannabis metabolites and self-report of recent cannabis consumption. CONCLUSIONS: In this sample, current cannabis use was not associated with deficits in striatal D(2)/D(3) receptor availability. There was an inverse relationship between chronic cannabis use and striatal RAC BP(ND). Additional studies are needed to identify the neurochemical consequences of chronic cannabis use on the dopamine system. SN - 1879-0046 UR - https://www.unboundmedicine.com/medline/citation/22909787/Striatal_D_2_/D_3__receptor_availability_is_inversely_correlated_with_cannabis_consumption_in_chronic_marijuana_users_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0376-8716(12)00290-6 DB - PRIME DP - Unbound Medicine ER -