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Determinants of preserved diastolic function at the lateral annulus in patients with isolated diastolic dysfunction.
Eur Heart J Cardiovasc Imaging. 2013 May; 14(5):443-8.EH

Abstract

AIMS

The reversal of the early diastolic mitral annular velocity (e') to the late diastolic mitral annular velocity (a') ratio (e'/a' <1) develops earlier in the septum than in the lateral mitral annulus on tissue Doppler imaging (TDI). Accordingly, patients with isolated diastolic dysfunction presenting as a reversed septal e'/a' ratio can be divided into two groups depending on the presence of a reversal of lateral e'/a'. The aim of this study was to identify the determinants of preserved diastolic function at the lateral annulus in patients with isolated diastolic dysfunction.

METHODS AND RESULTS

A total of 1166 consecutive patients with isolated diastolic dysfunction presenting as a reversed septal e'/a' were classified on the basis of their diastolic function at the lateral mitral annulus. Two hundred and fifteen patients had a preserved lateral e'/a' (e'/a' >1) and 915 patients had a reversed lateral e'/a' (e'/a' <1). Patients with lateral e'/a' >1 were younger, male, and had a lower prevalence of diabetes and hypertension and showed less evidence of left ventricular (LV) diastolic dysfunction and structural remodelling as LV hypertrophy and LA enlargement, than those with a lateral e'/a' <1. Multivariate analysis revealed that age, septal e', septal peak systolic annular velocity, and LV mass indexed to height(2.7) (LVM/h(2.7)) were independently associated with preserved diastolic function at the lateral annulus.

CONCLUSION

The age, septal TDI, and LVM/h(2.7) were independent determinants of preserved diastolic function at the lateral annulus in patients with isolated diastolic dysfunction presenting as a reversed septal e'/a' ratio.

Authors+Show Affiliations

Division of Cardiology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, # 896, Pyeongchon-dong, Dongan-gu, Anyang-Si, Gyeonggi-do 431-070, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22909794

Citation

Kim, Sung-Ai, et al. "Determinants of Preserved Diastolic Function at the Lateral Annulus in Patients With Isolated Diastolic Dysfunction." European Heart Journal Cardiovascular Imaging, vol. 14, no. 5, 2013, pp. 443-8.
Kim SA, Park WJ, Kim HJ, et al. Determinants of preserved diastolic function at the lateral annulus in patients with isolated diastolic dysfunction. Eur Heart J Cardiovasc Imaging. 2013;14(5):443-8.
Kim, S. A., Park, W. J., Kim, H. J., Jo, S. H., Kim, H. S., Han, S. J., & Rhim, C. Y. (2013). Determinants of preserved diastolic function at the lateral annulus in patients with isolated diastolic dysfunction. European Heart Journal Cardiovascular Imaging, 14(5), 443-8. https://doi.org/10.1093/ehjci/jes176
Kim SA, et al. Determinants of Preserved Diastolic Function at the Lateral Annulus in Patients With Isolated Diastolic Dysfunction. Eur Heart J Cardiovasc Imaging. 2013;14(5):443-8. PubMed PMID: 22909794.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Determinants of preserved diastolic function at the lateral annulus in patients with isolated diastolic dysfunction. AU - Kim,Sung-Ai, AU - Park,Woo-Jung, AU - Kim,Ho Joong, AU - Jo,Sang-Ho, AU - Kim,Hyun-Sook, AU - Han,Sang-Jin, AU - Rhim,Chong-Yun, Y1 - 2012/08/21/ PY - 2012/8/23/entrez PY - 2012/8/23/pubmed PY - 2013/11/15/medline SP - 443 EP - 8 JF - European heart journal cardiovascular Imaging JO - Eur Heart J Cardiovasc Imaging VL - 14 IS - 5 N2 - AIMS: The reversal of the early diastolic mitral annular velocity (e') to the late diastolic mitral annular velocity (a') ratio (e'/a' <1) develops earlier in the septum than in the lateral mitral annulus on tissue Doppler imaging (TDI). Accordingly, patients with isolated diastolic dysfunction presenting as a reversed septal e'/a' ratio can be divided into two groups depending on the presence of a reversal of lateral e'/a'. The aim of this study was to identify the determinants of preserved diastolic function at the lateral annulus in patients with isolated diastolic dysfunction. METHODS AND RESULTS: A total of 1166 consecutive patients with isolated diastolic dysfunction presenting as a reversed septal e'/a' were classified on the basis of their diastolic function at the lateral mitral annulus. Two hundred and fifteen patients had a preserved lateral e'/a' (e'/a' >1) and 915 patients had a reversed lateral e'/a' (e'/a' <1). Patients with lateral e'/a' >1 were younger, male, and had a lower prevalence of diabetes and hypertension and showed less evidence of left ventricular (LV) diastolic dysfunction and structural remodelling as LV hypertrophy and LA enlargement, than those with a lateral e'/a' <1. Multivariate analysis revealed that age, septal e', septal peak systolic annular velocity, and LV mass indexed to height(2.7) (LVM/h(2.7)) were independently associated with preserved diastolic function at the lateral annulus. CONCLUSION: The age, septal TDI, and LVM/h(2.7) were independent determinants of preserved diastolic function at the lateral annulus in patients with isolated diastolic dysfunction presenting as a reversed septal e'/a' ratio. SN - 2047-2412 UR - https://www.unboundmedicine.com/medline/citation/22909794/Determinants_of_preserved_diastolic_function_at_the_lateral_annulus_in_patients_with_isolated_diastolic_dysfunction_ DB - PRIME DP - Unbound Medicine ER -