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Possible interaction of cholinergic and GABAergic systems between MS and CA1 upon memory acquisition in rats.
Behav Brain Res. 2012 Dec 01; 235(2):231-43.BB

Abstract

The present study explored the possibility that cholinergic and GABAergic systems of medial septum (MS) might influence acquisition of memory by regulation of acetylcholine (Ach) and γ-aminobutyric acid (GABA) receptors function in hippocampus and vice versa. The step-through passive avoidance (PA) task was used. The results showed that pre-training intra-MS/CA1 administration of nonselective muscarinic Ach antagonist, scopolamine (0.5, 1 and 2 μg/rat) and GABA(A) receptor agonist, muscimol (0.01 and 0.02 μg/rat) impaired, while acetylcholinesterase inhibitor, physostigmine (0.5 and 1 μg/rat) and GABA(A) receptor antagonist, bicuculline (0.25 μg/rat) improved memory acquisition. Moreover, intra-CA1/MS administration of a subthreshold dose of muscimol or bicuculline increased and reversed the impairment induced by scopolamine in MS/CA1 respectively (cross injection). Also, the result revealed that, intra-CA1/MS administration subthreshold dose of muscimol reduced improvement of memory induced by physostigmine in the MS/CA1, respectively (cross injection). On the other hand, subthreshold dose of bicuculline in CA1/MS did not alter memory improvement induced by physostigmine in the other site (MS/CA1). In conclusion, both cholinergic and GABAergic systems not only seem to play a role in the modulation of memory in the MS and CA1 but also to have a complex interaction.

Authors+Show Affiliations

Department of Neuroscience, School of Advance Medical Technologies, Tehran, Iran.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22909986

Citation

Yousefi, Behnam, et al. "Possible Interaction of Cholinergic and GABAergic Systems Between MS and CA1 Upon Memory Acquisition in Rats." Behavioural Brain Research, vol. 235, no. 2, 2012, pp. 231-43.
Yousefi B, Nasehi M, Khakpai F, et al. Possible interaction of cholinergic and GABAergic systems between MS and CA1 upon memory acquisition in rats. Behav Brain Res. 2012;235(2):231-43.
Yousefi, B., Nasehi, M., Khakpai, F., & Zarrindast, M. R. (2012). Possible interaction of cholinergic and GABAergic systems between MS and CA1 upon memory acquisition in rats. Behavioural Brain Research, 235(2), 231-43. https://doi.org/10.1016/j.bbr.2012.08.006
Yousefi B, et al. Possible Interaction of Cholinergic and GABAergic Systems Between MS and CA1 Upon Memory Acquisition in Rats. Behav Brain Res. 2012 Dec 1;235(2):231-43. PubMed PMID: 22909986.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Possible interaction of cholinergic and GABAergic systems between MS and CA1 upon memory acquisition in rats. AU - Yousefi,Behnam, AU - Nasehi,Mohammad, AU - Khakpai,Fatemeh, AU - Zarrindast,Mohammad Reza, Y1 - 2012/08/13/ PY - 2012/05/24/received PY - 2012/08/01/revised PY - 2012/08/05/accepted PY - 2012/8/23/entrez PY - 2012/8/23/pubmed PY - 2013/2/26/medline SP - 231 EP - 43 JF - Behavioural brain research JO - Behav Brain Res VL - 235 IS - 2 N2 - The present study explored the possibility that cholinergic and GABAergic systems of medial septum (MS) might influence acquisition of memory by regulation of acetylcholine (Ach) and γ-aminobutyric acid (GABA) receptors function in hippocampus and vice versa. The step-through passive avoidance (PA) task was used. The results showed that pre-training intra-MS/CA1 administration of nonselective muscarinic Ach antagonist, scopolamine (0.5, 1 and 2 μg/rat) and GABA(A) receptor agonist, muscimol (0.01 and 0.02 μg/rat) impaired, while acetylcholinesterase inhibitor, physostigmine (0.5 and 1 μg/rat) and GABA(A) receptor antagonist, bicuculline (0.25 μg/rat) improved memory acquisition. Moreover, intra-CA1/MS administration of a subthreshold dose of muscimol or bicuculline increased and reversed the impairment induced by scopolamine in MS/CA1 respectively (cross injection). Also, the result revealed that, intra-CA1/MS administration subthreshold dose of muscimol reduced improvement of memory induced by physostigmine in the MS/CA1, respectively (cross injection). On the other hand, subthreshold dose of bicuculline in CA1/MS did not alter memory improvement induced by physostigmine in the other site (MS/CA1). In conclusion, both cholinergic and GABAergic systems not only seem to play a role in the modulation of memory in the MS and CA1 but also to have a complex interaction. SN - 1872-7549 UR - https://www.unboundmedicine.com/medline/citation/22909986/Possible_interaction_of_cholinergic_and_GABAergic_systems_between_MS_and_CA1_upon_memory_acquisition_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-4328(12)00524-4 DB - PRIME DP - Unbound Medicine ER -