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TRP channels and analgesia.
Life Sci. 2013 Mar 19; 92(8-9):415-24.LS

Abstract

Since cloning and characterizing the first nociceptive ion channel Transient Receptor Potential (TRP) Vanilloid 1 (TRPV1), other TRP channels involved in nociception have been cloned and characterized, which include TRP Vanilloid 2 (TRPV2), TRP Vanilloid 3 (TRPV3), TRP Vanilloid 4 (TRPV4), TRP Ankyrin 1 (TRPA1) and TRP Melastatin 8 (TRPM8), more recently TRP Canonical 1, 5, 6 (TRPC1, 5, 6), TRP Melastatin 2 (TRPM2) and TRP Melastatin 3 (TRPM3). These channels are predominantly expressed in C and Aδ nociceptors and transmit noxious thermal, mechanical and chemical sensitivities. TRP channels are modulated by pro-inflammatory mediators, neuropeptides and cytokines. Significant advances have been made targeting these receptors either by antagonists or agonists to treat painful conditions. In this review, we will discuss TRP channels as targets for next generation analgesics and the side effects that may ensue as a result of blocking/activating these receptors, because they are also involved in physiological functions such as release of vasoactive neuropeptides and regulation of vascular tone, maintenance of the body temperature, gastrointestinal motility, urinary bladder control, etc.

Authors+Show Affiliations

Department of Pharmacology, Southern Illinois University School of Medicine Springfield, IL 62702, USA. lpremkumar@siumed.eduNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

22910182

Citation

Premkumar, Louis S., and Mruvil Abooj. "TRP Channels and Analgesia." Life Sciences, vol. 92, no. 8-9, 2013, pp. 415-24.
Premkumar LS, Abooj M. TRP channels and analgesia. Life Sci. 2013;92(8-9):415-24.
Premkumar, L. S., & Abooj, M. (2013). TRP channels and analgesia. Life Sciences, 92(8-9), 415-24. https://doi.org/10.1016/j.lfs.2012.08.010
Premkumar LS, Abooj M. TRP Channels and Analgesia. Life Sci. 2013 Mar 19;92(8-9):415-24. PubMed PMID: 22910182.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - TRP channels and analgesia. AU - Premkumar,Louis S, AU - Abooj,Mruvil, Y1 - 2012/08/14/ PY - 2012/05/05/received PY - 2012/07/25/revised PY - 2012/08/02/accepted PY - 2012/8/23/entrez PY - 2012/8/23/pubmed PY - 2013/4/19/medline SP - 415 EP - 24 JF - Life sciences JO - Life Sci VL - 92 IS - 8-9 N2 - Since cloning and characterizing the first nociceptive ion channel Transient Receptor Potential (TRP) Vanilloid 1 (TRPV1), other TRP channels involved in nociception have been cloned and characterized, which include TRP Vanilloid 2 (TRPV2), TRP Vanilloid 3 (TRPV3), TRP Vanilloid 4 (TRPV4), TRP Ankyrin 1 (TRPA1) and TRP Melastatin 8 (TRPM8), more recently TRP Canonical 1, 5, 6 (TRPC1, 5, 6), TRP Melastatin 2 (TRPM2) and TRP Melastatin 3 (TRPM3). These channels are predominantly expressed in C and Aδ nociceptors and transmit noxious thermal, mechanical and chemical sensitivities. TRP channels are modulated by pro-inflammatory mediators, neuropeptides and cytokines. Significant advances have been made targeting these receptors either by antagonists or agonists to treat painful conditions. In this review, we will discuss TRP channels as targets for next generation analgesics and the side effects that may ensue as a result of blocking/activating these receptors, because they are also involved in physiological functions such as release of vasoactive neuropeptides and regulation of vascular tone, maintenance of the body temperature, gastrointestinal motility, urinary bladder control, etc. SN - 1879-0631 UR - https://www.unboundmedicine.com/medline/citation/22910182/TRP_channels_and_analgesia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0024-3205(12)00423-7 DB - PRIME DP - Unbound Medicine ER -