Tags

Type your tag names separated by a space and hit enter

Usefulness of pumpkin seeds combined with areca nut extract in community-based treatment of human taeniasis in northwest Sichuan Province, China.
Acta Trop. 2012 Nov; 124(2):152-7.AT

Abstract

Taeniasis refers to the infection with adult tapeworms of Taenia spp. in the upper small intestine of humans, which is also a cause of cysticercosis infection in either both humans and/or animals. Currently the most commonly applied anthelminthics for treatment of taeniasis are praziquantel and niclosamide. Praziquantel is very effective, but has the risk of induction of epileptic seizures or convulsions in carriers with asymptomatic concurrent neurocysticercosis. In contrast, niclosamide is safe and effective, but is not readily available in many endemic countries including China. In the current community-based study, we assessed the curative effect of either pumpkin seeds or areca nut extract alone in taeniasis, and also looked at synergistic effects of these two herb drugs on tapeworms. In the study group with the pumpkin seed/areca nut extract treatment, 91 (79.1%) of 115 suspected taeniasis cases (with a history of expulsion of proglottids within the previous one year) released whole tapeworms, four (3.5%) expelled incomplete strobila, and no tapeworms or proglottids were recovered in the remaining 20 cases. In these 115 persons, 45 were confirmed as taeniasis before treatment by microscopy and/or coproPCR. Forty (88.9%) of 45 confirmed cases eliminated intact worms following treatment. The mean time period for complete elimination of tapeworms in 91 taeniasis cases was 2 h (range 20 min to 8 h 30 min), and 89.0% (81) of 91 patients discharged intact worms within 3h after drug administration. In Control Group A with treatment of pumpkin seeds alone, 75.0% (9/12) of confirmed taeniasis cases expelled whole tapeworms, but the mean time period for complete elimination was about 14 h 10 min (range 3 h 20 min to 21 h 20 min), which was much longer than that (2 h) for the study group, whereas in Control Group B treated with areca nut extract alone, only 63.6% (7/11) of taeniasis cases discharged whole tapeworms, and the mean time period was 6 h 27 min (range 1-22 h). Mild side effects included nausea and dizziness in about 46.3% of patients with the pumpkin seeds/areca nut extract treatment, but all discomforts were transient and well tolerated. In conclusion, a synergistic effect of pumpkin seed and areca nut extract on Taenia spp. tapeworms was confirmed in the current study, primarily in producing an increased rate of effect on tapeworm expulsion (average time 2 h for combination vs 6-21 h for individual extracts). The pumpkin seed/areca combined treatment was indicated to be safe and highly effective (89%) for human taeniasis.

Authors+Show Affiliations

Institute of Parasitic Diseases, Sichuan Centers for Disease Control and Prevention, Sichuan Province, People's Republic of China. litiaoying@sina.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22910218

Citation

Li, Tiaoying, et al. "Usefulness of Pumpkin Seeds Combined With Areca Nut Extract in Community-based Treatment of Human Taeniasis in Northwest Sichuan Province, China." Acta Tropica, vol. 124, no. 2, 2012, pp. 152-7.
Li T, Ito A, Chen X, et al. Usefulness of pumpkin seeds combined with areca nut extract in community-based treatment of human taeniasis in northwest Sichuan Province, China. Acta Trop. 2012;124(2):152-7.
Li, T., Ito, A., Chen, X., Long, C., Okamoto, M., Raoul, F., Giraudoux, P., Yanagida, T., Nakao, M., Sako, Y., Xiao, N., & Craig, P. S. (2012). Usefulness of pumpkin seeds combined with areca nut extract in community-based treatment of human taeniasis in northwest Sichuan Province, China. Acta Tropica, 124(2), 152-7. https://doi.org/10.1016/j.actatropica.2012.08.002
Li T, et al. Usefulness of Pumpkin Seeds Combined With Areca Nut Extract in Community-based Treatment of Human Taeniasis in Northwest Sichuan Province, China. Acta Trop. 2012;124(2):152-7. PubMed PMID: 22910218.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Usefulness of pumpkin seeds combined with areca nut extract in community-based treatment of human taeniasis in northwest Sichuan Province, China. AU - Li,Tiaoying, AU - Ito,Akira, AU - Chen,Xingwang, AU - Long,Changping, AU - Okamoto,Munehiro, AU - Raoul,Francis, AU - Giraudoux,Patrick, AU - Yanagida,Tetsuya, AU - Nakao,Minoru, AU - Sako,Yasuhito, AU - Xiao,Ning, AU - Craig,Philip S, Y1 - 2012/08/11/ PY - 2011/12/08/received PY - 2012/08/02/revised PY - 2012/08/04/accepted PY - 2012/8/23/entrez PY - 2012/8/23/pubmed PY - 2013/1/18/medline SP - 152 EP - 7 JF - Acta tropica JO - Acta Trop. VL - 124 IS - 2 N2 - Taeniasis refers to the infection with adult tapeworms of Taenia spp. in the upper small intestine of humans, which is also a cause of cysticercosis infection in either both humans and/or animals. Currently the most commonly applied anthelminthics for treatment of taeniasis are praziquantel and niclosamide. Praziquantel is very effective, but has the risk of induction of epileptic seizures or convulsions in carriers with asymptomatic concurrent neurocysticercosis. In contrast, niclosamide is safe and effective, but is not readily available in many endemic countries including China. In the current community-based study, we assessed the curative effect of either pumpkin seeds or areca nut extract alone in taeniasis, and also looked at synergistic effects of these two herb drugs on tapeworms. In the study group with the pumpkin seed/areca nut extract treatment, 91 (79.1%) of 115 suspected taeniasis cases (with a history of expulsion of proglottids within the previous one year) released whole tapeworms, four (3.5%) expelled incomplete strobila, and no tapeworms or proglottids were recovered in the remaining 20 cases. In these 115 persons, 45 were confirmed as taeniasis before treatment by microscopy and/or coproPCR. Forty (88.9%) of 45 confirmed cases eliminated intact worms following treatment. The mean time period for complete elimination of tapeworms in 91 taeniasis cases was 2 h (range 20 min to 8 h 30 min), and 89.0% (81) of 91 patients discharged intact worms within 3h after drug administration. In Control Group A with treatment of pumpkin seeds alone, 75.0% (9/12) of confirmed taeniasis cases expelled whole tapeworms, but the mean time period for complete elimination was about 14 h 10 min (range 3 h 20 min to 21 h 20 min), which was much longer than that (2 h) for the study group, whereas in Control Group B treated with areca nut extract alone, only 63.6% (7/11) of taeniasis cases discharged whole tapeworms, and the mean time period was 6 h 27 min (range 1-22 h). Mild side effects included nausea and dizziness in about 46.3% of patients with the pumpkin seeds/areca nut extract treatment, but all discomforts were transient and well tolerated. In conclusion, a synergistic effect of pumpkin seed and areca nut extract on Taenia spp. tapeworms was confirmed in the current study, primarily in producing an increased rate of effect on tapeworm expulsion (average time 2 h for combination vs 6-21 h for individual extracts). The pumpkin seed/areca combined treatment was indicated to be safe and highly effective (89%) for human taeniasis. SN - 1873-6254 UR - https://www.unboundmedicine.com/medline/citation/22910218/Usefulness_of_pumpkin_seeds_combined_with_areca_nut_extract_in_community_based_treatment_of_human_taeniasis_in_northwest_Sichuan_Province_China_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0001-706X(12)00274-4 DB - PRIME DP - Unbound Medicine ER -