Tags

Type your tag names separated by a space and hit enter

Cranberry juice for the prevention of pediatric urinary tract infection: a randomized controlled trial.
J Urol. 2012 Oct; 188(4 Suppl):1584-7.JU

Abstract

PURPOSE

Proanthocyanidins found in cranberry have been reported to have in vitro and in vivo antibacterial activity. We determined the effectiveness of cranberry juice for the prevention of urinary tract infections in children.

MATERIALS AND METHODS

A total of 40 children were randomized to receive daily cranberry juice with high concentrations of proanthocyanidin vs cranberry juice with no proanthocyanidin for a 1-year period. The study was powered to detect a 30% decrease in the rate of symptomatic urinary tract infection with type I and II errors of 0.05 and 0.2, respectively. Toilet trained children up to age 18 years were eligible if they had at least 2 culture documented nonfebrile urinary tract infections in the calendar year before enrollment. Patients with anatomical abnormalities (except for primary vesicoureteral reflux) were excluded from study. Subjects were followed for 12 months. The participants, clinicians, outcome assessor and statistician were all blinded to treatment allocation.

RESULTS

Of the children 39 girls and 1 boy were recruited. Mean and median patient age was 9.5 and 7 years, respectively (range 5 to 18). There were 20 patients with comparable baseline characteristics randomized to each group. After 12 months of followup the average incidence of urinary tract infection in the treatment group was 0.4 per patient per year and 1.15 in the placebo group (p = 0.045), representing a 65% reduction in the risk of urinary tract infection.

CONCLUSIONS

Cranberry juice with high concentrations of proanthocyanidin appears to be effective in the prevention of pediatric nonfebrile urinary tract infections. Further studies are required to determine the cost-effectiveness of this approach.

Authors+Show Affiliations

Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada. kafshar@cw.bc.caNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

22910239

Citation

Afshar, K, et al. "Cranberry Juice for the Prevention of Pediatric Urinary Tract Infection: a Randomized Controlled Trial." The Journal of Urology, vol. 188, no. 4 Suppl, 2012, pp. 1584-7.
Afshar K, Stothers L, Scott H, et al. Cranberry juice for the prevention of pediatric urinary tract infection: a randomized controlled trial. J Urol. 2012;188(4 Suppl):1584-7.
Afshar, K., Stothers, L., Scott, H., & MacNeily, A. E. (2012). Cranberry juice for the prevention of pediatric urinary tract infection: a randomized controlled trial. The Journal of Urology, 188(4 Suppl), 1584-7. https://doi.org/10.1016/j.juro.2012.02.031
Afshar K, et al. Cranberry Juice for the Prevention of Pediatric Urinary Tract Infection: a Randomized Controlled Trial. J Urol. 2012;188(4 Suppl):1584-7. PubMed PMID: 22910239.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cranberry juice for the prevention of pediatric urinary tract infection: a randomized controlled trial. AU - Afshar,K, AU - Stothers,L, AU - Scott,H, AU - MacNeily,A E, Y1 - 2012/08/19/ PY - 2011/11/29/received PY - 2012/8/23/entrez PY - 2012/8/23/pubmed PY - 2013/1/1/medline SP - 1584 EP - 7 JF - The Journal of urology JO - J. Urol. VL - 188 IS - 4 Suppl N2 - PURPOSE: Proanthocyanidins found in cranberry have been reported to have in vitro and in vivo antibacterial activity. We determined the effectiveness of cranberry juice for the prevention of urinary tract infections in children. MATERIALS AND METHODS: A total of 40 children were randomized to receive daily cranberry juice with high concentrations of proanthocyanidin vs cranberry juice with no proanthocyanidin for a 1-year period. The study was powered to detect a 30% decrease in the rate of symptomatic urinary tract infection with type I and II errors of 0.05 and 0.2, respectively. Toilet trained children up to age 18 years were eligible if they had at least 2 culture documented nonfebrile urinary tract infections in the calendar year before enrollment. Patients with anatomical abnormalities (except for primary vesicoureteral reflux) were excluded from study. Subjects were followed for 12 months. The participants, clinicians, outcome assessor and statistician were all blinded to treatment allocation. RESULTS: Of the children 39 girls and 1 boy were recruited. Mean and median patient age was 9.5 and 7 years, respectively (range 5 to 18). There were 20 patients with comparable baseline characteristics randomized to each group. After 12 months of followup the average incidence of urinary tract infection in the treatment group was 0.4 per patient per year and 1.15 in the placebo group (p = 0.045), representing a 65% reduction in the risk of urinary tract infection. CONCLUSIONS: Cranberry juice with high concentrations of proanthocyanidin appears to be effective in the prevention of pediatric nonfebrile urinary tract infections. Further studies are required to determine the cost-effectiveness of this approach. SN - 1527-3792 UR - https://www.unboundmedicine.com/medline/citation/22910239/Cranberry_juice_for_the_prevention_of_pediatric_urinary_tract_infection:_a_randomized_controlled_trial_ L2 - https://www.jurology.com/doi/full/10.1016/j.juro.2012.02.031?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -